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Article: Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation

TitleClinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation
Authors
KeywordsBone marrow transplantation
Haemorrhagic cystitis
Polyoma BK virus
Issue Date2002
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2002, v. 29 n. 6, p. 509-513 How to Cite?
AbstractHaemorrhagic cystitis (HC) is an important complication after bone marrow transplantation (BMT). Overt HC (grade ≥2, gross haematuria, clot retention and impairment of renal function), clinically more important than mild and occult HC (grade 1, microscopic haematuria), leads to substantial morbidity and occasional mortality. We retrospectively analyzed 32 cases of clinically overt HC from a series of 236 BMT patients. Significant risk factors included the use of busulphan during conditioning, allogeneic BMT and acute GVHD. Logistic regression showed GVHD to be the most important risk factor. According to the time of engraftment, HC could be divided into pre- and post-engraftment subtypes. Pre-engraftment HC was brief, not more severe than grade 2, and subsided with supportive treatment. In contrast, post-engraftment HC was protracted, often of grade ≥3, associated with severe GVHD, and required surgical intervention in many cases. Polyoma BK viruria, but not adenoviruria, could be demonstrated in both types of HC. The increased severity and association with GVHD of post-engraftment HC suggested that attack of urothelium by immunocompetent cells, possibly directed against BK viral antigens, might play a pathogenetic role.
Persistent Identifierhttp://hdl.handle.net/10722/78426
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorMak, Ren_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:42:45Z-
dc.date.available2010-09-06T07:42:45Z-
dc.date.issued2002en_HK
dc.identifier.citationBone Marrow Transplantation, 2002, v. 29 n. 6, p. 509-513en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78426-
dc.description.abstractHaemorrhagic cystitis (HC) is an important complication after bone marrow transplantation (BMT). Overt HC (grade ≥2, gross haematuria, clot retention and impairment of renal function), clinically more important than mild and occult HC (grade 1, microscopic haematuria), leads to substantial morbidity and occasional mortality. We retrospectively analyzed 32 cases of clinically overt HC from a series of 236 BMT patients. Significant risk factors included the use of busulphan during conditioning, allogeneic BMT and acute GVHD. Logistic regression showed GVHD to be the most important risk factor. According to the time of engraftment, HC could be divided into pre- and post-engraftment subtypes. Pre-engraftment HC was brief, not more severe than grade 2, and subsided with supportive treatment. In contrast, post-engraftment HC was protracted, often of grade ≥3, associated with severe GVHD, and required surgical intervention in many cases. Polyoma BK viruria, but not adenoviruria, could be demonstrated in both types of HC. The increased severity and association with GVHD of post-engraftment HC suggested that attack of urothelium by immunocompetent cells, possibly directed against BK viral antigens, might play a pathogenetic role.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subjectBone marrow transplantationen_HK
dc.subjectHaemorrhagic cystitisen_HK
dc.subjectPolyoma BK virusen_HK
dc.subject.meshAdenoviridae - isolation & purificationen_HK
dc.subject.meshAdenoviridae Infections - etiology - pathologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBK Virus - isolation & purificationen_HK
dc.subject.meshBone Marrow Transplantation - adverse effects - methods - pathologyen_HK
dc.subject.meshBusulfan - adverse effects - therapeutic useen_HK
dc.subject.meshCystitis - etiology - pathology - urine - virologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemorrhage - etiology - pathology - surgery - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunosuppressive Agents - adverse effects - therapeutic useen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPapillomavirus Infections - etiology - pathologyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshTherapeutic Irrigation - methodsen_HK
dc.subject.meshTransplantation Conditioning - adverse effects - methodsen_HK
dc.subject.meshTumor Virus Infections - etiology - pathologyen_HK
dc.subject.meshUrinary Bladder - metabolism - pathologyen_HK
dc.titleClinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=29&spage=509&epage=513&date=2002&atitle=Clinicopathological+features+and+risk+factors+of+clinically+overt+haemorrhagic+cystitis+complicating+bone+marrow+transplantation.en_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj/bmt/1703415en_HK
dc.identifier.pmid11960271-
dc.identifier.scopuseid_2-s2.0-0036240659en_HK
dc.identifier.hkuros66609en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036240659&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue6en_HK
dc.identifier.spage509en_HK
dc.identifier.epage513en_HK
dc.identifier.isiWOS:000175018500009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridMak, R=36893012300en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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