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Article: Chronic Helicobacter pylori infection induces apoptosis-resistance in gastric epithelial cells

TitleChronic Helicobacter pylori infection induces apoptosis-resistance in gastric epithelial cells
Authors
Issue Date2003
Publisher中華醫學會. The Journal's web site is located at http://zhyx.chinajournal.net.cn/
Citation
Zhonghua Yi Xue Za Zhi, 2003, v. 83 n. 1, p. 42-45 How to Cite?
AbstractOBJECTIVE: To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, and to determine the effect of chronic H.pylori infection on apoptosis of gastric epithelial cells. METHODS: Human non-tumor gastric epithelial cells GES-1 were cocultured with an H.pylori strain SS1 for 16 weeks, in order to obtain GES-1 "model" cells. Biological characteristics of the model cells including growth, adherence and clone formation were determined. Apoptosis of the "model" cells in response to apoptosis inducers such as H.pylori and other enterobacteria and agents commonly used in the chemotherapy of gastric cancer were measured by flow cytometry. RESULTS: A cell model of human gastric epithelial cells with chronic H.pylori infection (GES-1 model cells) was successfully established. Apoptosis was dramatically decreased in the "model" cells with and without stimulation by H.pylori and other enterobacteria and some chemotherapeutic agents. CONCLUSION: Chronic H.pylori infection induces apoptosis resistance in gastric epithelial cells, which may increase the risk of the development of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/78392
ISSN
2015 SCImago Journal Rankings: 0.134

 

DC FieldValueLanguage
dc.contributor.authorHe, XXen_HK
dc.contributor.authorHu, PJen_HK
dc.contributor.authorWong, BCen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorXia, HHen_HK
dc.date.accessioned2010-09-06T07:42:22Z-
dc.date.available2010-09-06T07:42:22Z-
dc.date.issued2003en_HK
dc.identifier.citationZhonghua Yi Xue Za Zhi, 2003, v. 83 n. 1, p. 42-45en_HK
dc.identifier.issn0376-2491en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78392-
dc.description.abstractOBJECTIVE: To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, and to determine the effect of chronic H.pylori infection on apoptosis of gastric epithelial cells. METHODS: Human non-tumor gastric epithelial cells GES-1 were cocultured with an H.pylori strain SS1 for 16 weeks, in order to obtain GES-1 "model" cells. Biological characteristics of the model cells including growth, adherence and clone formation were determined. Apoptosis of the "model" cells in response to apoptosis inducers such as H.pylori and other enterobacteria and agents commonly used in the chemotherapy of gastric cancer were measured by flow cytometry. RESULTS: A cell model of human gastric epithelial cells with chronic H.pylori infection (GES-1 model cells) was successfully established. Apoptosis was dramatically decreased in the "model" cells with and without stimulation by H.pylori and other enterobacteria and some chemotherapeutic agents. CONCLUSION: Chronic H.pylori infection induces apoptosis resistance in gastric epithelial cells, which may increase the risk of the development of gastric cancer.en_HK
dc.languageengen_HK
dc.publisher中華醫學會. The Journal's web site is located at http://zhyx.chinajournal.net.cn/en_HK
dc.relation.ispartofZhonghua yi xue za zhien_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshEpithelial Cells - pathologyen_HK
dc.subject.meshGastric Mucosa - pathologyen_HK
dc.subject.meshHelicobacter Infections - pathologyen_HK
dc.subject.meshHelicobacter pylorien_HK
dc.subject.meshHumansen_HK
dc.titleChronic Helicobacter pylori infection induces apoptosis-resistance in gastric epithelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0376-2491&volume=83&issue=1&spage=42&epage=45&date=2003&atitle=Chronic+Helicobacter+pylori+infection+induces+apoptosis-resistance+in+gastric+epithelial+cellsen_HK
dc.identifier.emailWong, BC:bcywong@hku.hken_HK
dc.identifier.authorityWong, BC=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12757644-
dc.identifier.scopuseid_2-s2.0-0042266762en_HK
dc.identifier.hkuros82288en_HK
dc.identifier.volume83en_HK
dc.identifier.issue1en_HK
dc.identifier.spage42en_HK
dc.identifier.epage45en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridHe, XX=7404408745en_HK
dc.identifier.scopusauthoridHu, PJ=7201989582en_HK
dc.identifier.scopusauthoridWong, BC=7402023340en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridXia, HH=8757161400en_HK

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