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Article: Effects of plasticisers and related compounds on the expression of the soluble form of catechol-o-methyltransferase in MCF-7 cells

TitleEffects of plasticisers and related compounds on the expression of the soluble form of catechol-o-methyltransferase in MCF-7 cells
Authors
KeywordsCOMT
Endocrine disruption
Estrogen
Phthalate
Plasticiser
Issue Date2008
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdm/index.htm
Citation
Current Drug Metabolism, 2008, v. 9 n. 4, p. 276-279 How to Cite?
AbstractPreviously we have shown that E2 down regulates S-COMT expression. Here the effects of four phthalate esters and 4-(tertoctyl) phenol on the intra-cellular levels of S-COMT and COMT activity were studied in MCF-7 cells as a measure of estrogenic activity of these compounds. The four phthalate esters caused significant reductions in both S-COMT protein and COMT activity levels. These effects were inhibited by the ERα receptor antagonist ICI182780. 4-(tert-octyl)phenol also caused reductions in these parameters, but the effects were not abolished by ICI182780. Assay of S-COMT protein levels represents a simple and convenient method of assessing the estrogenic potential of a compound. © 2008 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/78370
ISSN
2015 Impact Factor: 2.847
2015 SCImago Journal Rankings: 0.976
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PWLen_HK
dc.contributor.authorChu, ACYen_HK
dc.contributor.authorKwok, KHHen_HK
dc.contributor.authorLiu, HFen_HK
dc.contributor.authorKung, MHWen_HK
dc.contributor.authorRamsden, DBen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-09-06T07:42:07Z-
dc.date.available2010-09-06T07:42:07Z-
dc.date.issued2008en_HK
dc.identifier.citationCurrent Drug Metabolism, 2008, v. 9 n. 4, p. 276-279en_HK
dc.identifier.issn1389-2002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78370-
dc.description.abstractPreviously we have shown that E2 down regulates S-COMT expression. Here the effects of four phthalate esters and 4-(tertoctyl) phenol on the intra-cellular levels of S-COMT and COMT activity were studied in MCF-7 cells as a measure of estrogenic activity of these compounds. The four phthalate esters caused significant reductions in both S-COMT protein and COMT activity levels. These effects were inhibited by the ERα receptor antagonist ICI182780. 4-(tert-octyl)phenol also caused reductions in these parameters, but the effects were not abolished by ICI182780. Assay of S-COMT protein levels represents a simple and convenient method of assessing the estrogenic potential of a compound. © 2008 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdm/index.htmen_HK
dc.relation.ispartofCurrent Drug Metabolismen_HK
dc.subjectCOMTen_HK
dc.subjectEndocrine disruptionen_HK
dc.subjectEstrogenen_HK
dc.subjectPhthalateen_HK
dc.subjectPlasticiseren_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCatechol O-Methyltransferase - biosynthesisen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_HK
dc.subject.meshEnvironmental Pollutants - toxicityen_HK
dc.subject.meshEstradiol - pharmacologyen_HK
dc.subject.meshGene Expression Regulation, Enzymologic - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIndicators and Reagentsen_HK
dc.subject.meshPhthalic Acids - toxicityen_HK
dc.subject.meshPlasticizers - toxicityen_HK
dc.subject.meshPolychlorinated Biphenyls - pharmacologyen_HK
dc.titleEffects of plasticisers and related compounds on the expression of the soluble form of catechol-o-methyltransferase in MCF-7 cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1389-2002&volume=9&issue=4&spage=276&epage=279&date=2008&atitle=Effects+of+plasticisers+and+related+compounds+on+the+expression+of+the+soluble+form+of+catechol-O-methyltransferase+in+MCF-7+cells.en_HK
dc.identifier.emailHo, PWL: hwl2002@hku.hken_HK
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hken_HK
dc.identifier.emailHo, SL: slho@hku.hken_HK
dc.identifier.authorityHo, PWL=rp00259en_HK
dc.identifier.authorityChu, ACY=rp00505en_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/138920008784220628en_HK
dc.identifier.pmid18473745-
dc.identifier.scopuseid_2-s2.0-45249111516en_HK
dc.identifier.hkuros142949en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45249111516&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue4en_HK
dc.identifier.spage276en_HK
dc.identifier.epage279en_HK
dc.identifier.isiWOS:000255682300003-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHo, PWL=25027612100en_HK
dc.identifier.scopusauthoridChu, ACY=24343085700en_HK
dc.identifier.scopusauthoridKwok, KHH=7102194193en_HK
dc.identifier.scopusauthoridLiu, HF=27170235100en_HK
dc.identifier.scopusauthoridKung, MHW=36336960300en_HK
dc.identifier.scopusauthoridRamsden, DB=7102612805en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK
dc.identifier.citeulike2750297-

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