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Article: Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients

TitleIncreased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients
Authors
KeywordsCOX-2
First-degree relatives
Gastric cancer
H pylori
Issue Date2005
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2005, v. 11 n. 31, p. 4918-4922 How to Cite?
AbstractAim: To study the expression of cyclooxygenase-2 (COX-2) in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients. Methods: The expression of COX-2 mRNA in 38 patients with gastric cancer and their 29 first-degree relatives and 18 healthy controls was assessed by the real time RT-PCR. The expression of COX-2 protein was determined by Western blot. Results: A marked increase in COX-2 mRNA expression was found in 20 of 37 (54%) cancerous tissues compared to their respective paired normal mucosa (P<0.001). Interestingly, increased COX-2 mRNA expression was also found in mucosa of the corpus (6/29) and antrum (13/29) of their first-degree relatives. Increased COX-2 mRNA expression was more frequently observed in the antrum biopsies from cancer patients than in the antrum biopsies from healthy controls (P<0.05). In addition, 3 of 23 (13%) patients with atrophic mucosa and 6 of 35 (17%) patients with intestinal metaplasia showed increased COX-2 mRNA expression. Furthermore, COX-2 expression increased in H pylori-positive tissues, especially in antrum mucosa. Conclusion: Increased COX-2 expression is involved in gastric carcinogenesis, and may be necessary for maintenance of the malignant phenotype and contribute to Helicobacter pylori-associated malignant transformation. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78366
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, JTen_HK
dc.contributor.authorWang, MWen_HK
dc.contributor.authorZhu, ZLen_HK
dc.contributor.authorHuo, XHen_HK
dc.contributor.authorChu, JKen_HK
dc.contributor.authorCui, DSen_HK
dc.contributor.authorQiao, Len_HK
dc.contributor.authorYu, Jen_HK
dc.date.accessioned2010-09-06T07:42:04Z-
dc.date.available2010-09-06T07:42:04Z-
dc.date.issued2005en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2005, v. 11 n. 31, p. 4918-4922en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78366-
dc.description.abstractAim: To study the expression of cyclooxygenase-2 (COX-2) in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients. Methods: The expression of COX-2 mRNA in 38 patients with gastric cancer and their 29 first-degree relatives and 18 healthy controls was assessed by the real time RT-PCR. The expression of COX-2 protein was determined by Western blot. Results: A marked increase in COX-2 mRNA expression was found in 20 of 37 (54%) cancerous tissues compared to their respective paired normal mucosa (P<0.001). Interestingly, increased COX-2 mRNA expression was also found in mucosa of the corpus (6/29) and antrum (13/29) of their first-degree relatives. Increased COX-2 mRNA expression was more frequently observed in the antrum biopsies from cancer patients than in the antrum biopsies from healthy controls (P<0.05). In addition, 3 of 23 (13%) patients with atrophic mucosa and 6 of 35 (17%) patients with intestinal metaplasia showed increased COX-2 mRNA expression. Furthermore, COX-2 expression increased in H pylori-positive tissues, especially in antrum mucosa. Conclusion: Increased COX-2 expression is involved in gastric carcinogenesis, and may be necessary for maintenance of the malignant phenotype and contribute to Helicobacter pylori-associated malignant transformation. © 2005 The WJG Press and Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCOX-2en_HK
dc.subjectFirst-degree relativesen_HK
dc.subjectGastric canceren_HK
dc.subjectH pylorien_HK
dc.titleIncreased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=&spage=4918&epage=4922&date=2005&atitle=Increased+expression+of+cyclooxygenase-2+in+first-degree+relatives+of+gastric+cancer+patientsen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v11.i31.4918-
dc.identifier.pmid16097073en_HK
dc.identifier.pmcidPMC4398751-
dc.identifier.scopuseid_2-s2.0-24044435518en_HK
dc.identifier.hkuros132393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24044435518&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue31en_HK
dc.identifier.spage4918en_HK
dc.identifier.epage4922en_HK
dc.identifier.isiWOS:000208317800031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, JT=8933807900en_HK
dc.identifier.scopusauthoridWang, MW=9247026700en_HK
dc.identifier.scopusauthoridZhu, ZL=8533022300en_HK
dc.identifier.scopusauthoridHuo, XH=13806004800en_HK
dc.identifier.scopusauthoridChu, JK=8533022500en_HK
dc.identifier.scopusauthoridCui, DS=8533022600en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridYu, J=35351306800en_HK

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