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Article: Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice

TitleMelatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice
Authors
Issue Date2006
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPI
Citation
Journal Of Pineal Research, 2006, v. 41 n. 2, p. 150-156 How to Cite?
AbstractCyclooxygenase (COX)-2 plays a harmful role in cerebral ischemic/reperfusion injury, but the role of COX-1 is uncertain. In the present study, cerebral infarct was induced by photothrombosis. Intraperitoneal injections of melatonin at 15 g/kg or its vehicle were made at 0.5 hr before stroke and 24 and 48 hr after stroke. Cerebral blood flow (CBF) in the penumbra was monitored during stroke using a laser Doppler flowmeter. Sensorimotor behavior was evaluated using the turning in an alley and falling from a pole tests at 1 hr before stroke and 24 and 48 hr after stroke. Infarct volume was determined from the T2-weighted magnetic resonance images at 72 hr after stroke. During the first 15 min of stroke, CBF decreased in the penumbra in both homozygous COX-1-gene knockout and wild-type mice. Melatonin treatment improved the penumbral CBF in the wild-type mice. Mild poststroke impairment in sensorimotor behavior was detected by the turning in an alley test in which the COX-1-gene knockout mice performed better. Melatonin treatment did not affect the poststroke sensorimotor behavior. The relative infarct volume at 72 hr after stroke was 8.1% and 8.4% in the COX-1-gene knockout and wild-type mice, respectively. Melatonin treatment reduced the relative infarct volume to 6.3% in the latter but not in the former (8.2%). Thus, COX-1-gene knockout does not affect the brain's susceptibility to photothrombotic stroke. Melatonin treatment reduces infarct size in the wild-type mice following photothrombotic stroke partly via maintenance of penumbral CBF in which the COX-1-gene may play a role. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/78349
ISSN
2015 Impact Factor: 9.314
2015 SCImago Journal Rankings: 2.655
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiang, YZen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorLiu, Sen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorHuang, Len_HK
dc.date.accessioned2010-09-06T07:41:53Z-
dc.date.available2010-09-06T07:41:53Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Pineal Research, 2006, v. 41 n. 2, p. 150-156en_HK
dc.identifier.issn0742-3098en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78349-
dc.description.abstractCyclooxygenase (COX)-2 plays a harmful role in cerebral ischemic/reperfusion injury, but the role of COX-1 is uncertain. In the present study, cerebral infarct was induced by photothrombosis. Intraperitoneal injections of melatonin at 15 g/kg or its vehicle were made at 0.5 hr before stroke and 24 and 48 hr after stroke. Cerebral blood flow (CBF) in the penumbra was monitored during stroke using a laser Doppler flowmeter. Sensorimotor behavior was evaluated using the turning in an alley and falling from a pole tests at 1 hr before stroke and 24 and 48 hr after stroke. Infarct volume was determined from the T2-weighted magnetic resonance images at 72 hr after stroke. During the first 15 min of stroke, CBF decreased in the penumbra in both homozygous COX-1-gene knockout and wild-type mice. Melatonin treatment improved the penumbral CBF in the wild-type mice. Mild poststroke impairment in sensorimotor behavior was detected by the turning in an alley test in which the COX-1-gene knockout mice performed better. Melatonin treatment did not affect the poststroke sensorimotor behavior. The relative infarct volume at 72 hr after stroke was 8.1% and 8.4% in the COX-1-gene knockout and wild-type mice, respectively. Melatonin treatment reduced the relative infarct volume to 6.3% in the latter but not in the former (8.2%). Thus, COX-1-gene knockout does not affect the brain's susceptibility to photothrombotic stroke. Melatonin treatment reduces infarct size in the wild-type mice following photothrombotic stroke partly via maintenance of penumbral CBF in which the COX-1-gene may play a role. © 2006 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPIen_HK
dc.relation.ispartofJournal of Pineal Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - blood supply - drug effects - pathologyen_HK
dc.subject.meshBrain Edema - pathologyen_HK
dc.subject.meshCerebral Infarction - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshCerebrovascular Circulation - drug effectsen_HK
dc.subject.meshCyclooxygenase 1 - geneticsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshLaser-Doppler Flowmetryen_HK
dc.subject.meshMelatonin - administration & dosage - therapeutic useen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Knockouten_HK
dc.subject.meshMotor Skillsen_HK
dc.subject.meshNeuroprotective Agents - therapeutic useen_HK
dc.subject.meshReperfusion Injury - physiopathologyen_HK
dc.subject.meshRose Bengalen_HK
dc.subject.meshThrombosis - metabolismen_HK
dc.titleMelatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0742-3098&volume=41&spage=150&epage=156&date=2006&atitle=Melatonin+reduces+infarction+volume+in+a+photothrombotic+stroke+model+in+the+wild-type+but+not+cyclooxygenase-1-gene+knockout+miceen_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-079X.2006.00349.xen_HK
dc.identifier.pmid16879321-
dc.identifier.scopuseid_2-s2.0-33746508995en_HK
dc.identifier.hkuros130496en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746508995&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue2en_HK
dc.identifier.spage150en_HK
dc.identifier.epage156en_HK
dc.identifier.isiWOS:000239371000009-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridLiang, YZ=14052218400en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridLiu, S=14052125200en_HK
dc.identifier.scopusauthoridLi, G=35767974200en_HK
dc.identifier.scopusauthoridHuang, L=36925330700en_HK
dc.identifier.citeulike781038-

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