File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Plasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus

TitlePlasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2005, v. 178 n. 2, p. 365-370 How to Cite?
AbstractPhospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins, and plays an essential role in HDL metabolism. The regulation of PLTP is poorly understood and recent evidence suggests that PLTP activity increases during acute-phase response. Since type 2 diabetes is associated with chronic subclinical inflammation, the objective is to determine whether inflammation modulates PLTP activity in diabetes. Plasma PLTP activity was assayed by measuring the transfer of radiolabeled phosphatidylcholine from liposomes to HDL and high-sensitivity C-reactive protein (CRP) by immunoturbidimetric assay in 280 type 2 diabetic patients and 105 controls. Plasma PLTP activity (2364 ± 651 nmol/ml/h versus 1880 ± 586 nmol/ml/h in control, mean ± S.D., P < 0.01) and CRP (1.64 (0.89-3.23) mg/l versus 0.99 (0.53-2.33) mg/l, median (interquartile range), P < 0.01) were increased in diabetic subjects. PLTP activity correlated significantly with age, BMI, HbA1c, log(CRP) and apolipoprotein AI and B in diabetic subjects. General linear model analysis showed that only apolipoprotein AI, age, BMI and log(CRP) were independent determinants of PLTP activity. In conclusion, PLTP activity is increased in diabetes and apolipoprotein AI is a major determinant of PLTP activity. There is also an independent association between CRP and PLTP activity, suggesting that subclinical inflammation may influence PLTP activity in diabetes. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78321
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorWong, Yen_HK
dc.contributor.authorTam, Sen_HK
dc.date.accessioned2010-09-06T07:41:35Z-
dc.date.available2010-09-06T07:41:35Z-
dc.date.issued2005en_HK
dc.identifier.citationAtherosclerosis, 2005, v. 178 n. 2, p. 365-370en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78321-
dc.description.abstractPhospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins, and plays an essential role in HDL metabolism. The regulation of PLTP is poorly understood and recent evidence suggests that PLTP activity increases during acute-phase response. Since type 2 diabetes is associated with chronic subclinical inflammation, the objective is to determine whether inflammation modulates PLTP activity in diabetes. Plasma PLTP activity was assayed by measuring the transfer of radiolabeled phosphatidylcholine from liposomes to HDL and high-sensitivity C-reactive protein (CRP) by immunoturbidimetric assay in 280 type 2 diabetic patients and 105 controls. Plasma PLTP activity (2364 ± 651 nmol/ml/h versus 1880 ± 586 nmol/ml/h in control, mean ± S.D., P < 0.01) and CRP (1.64 (0.89-3.23) mg/l versus 0.99 (0.53-2.33) mg/l, median (interquartile range), P < 0.01) were increased in diabetic subjects. PLTP activity correlated significantly with age, BMI, HbA1c, log(CRP) and apolipoprotein AI and B in diabetic subjects. General linear model analysis showed that only apolipoprotein AI, age, BMI and log(CRP) were independent determinants of PLTP activity. In conclusion, PLTP activity is increased in diabetes and apolipoprotein AI is a major determinant of PLTP activity. There is also an independent association between CRP and PLTP activity, suggesting that subclinical inflammation may influence PLTP activity in diabetes. © 2004 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.rightsAtherosclerosis. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAcute-Phase Reaction - etiologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshApolipoprotein A-I - pharmacologyen_HK
dc.subject.meshC-Reactive Protein - analysis - pharmacologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - complications - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoassayen_HK
dc.subject.meshInflammationen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Proteins - blood - pharmacologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPhospholipid Transfer Proteins - blood - pharmacologyen_HK
dc.titlePlasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=178&issue=2&spage=365&epage=70&date=2005&atitle=Plasma+phospholipid+transfer+protein+activity+and+subclinical+inflammation+in+type+2+diabetes+mellitusen_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2004.09.005en_HK
dc.identifier.pmid15754464-
dc.identifier.scopuseid_2-s2.0-13244273629en_HK
dc.identifier.hkuros98976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13244273629&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume178en_HK
dc.identifier.issue2en_HK
dc.identifier.spage365en_HK
dc.identifier.epage370en_HK
dc.identifier.isiWOS:000227200800020-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridWong, Y=24073787400en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats