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Article: Vision-threatening complications of nasal T/NK lymphoma

TitleVision-threatening complications of nasal T/NK lymphoma
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajo
Citation
American Journal Of Ophthalmology, 2002, v. 134 n. 3, p. 406-410 How to Cite?
AbstractPURPOSE: Nasal T/NK lineage lymphoma, previously known as lethal midline granuloma, is common among Oriental, Native-American, and Hispanic patients and is invariably associated with Epstein-Barr virus. Nasal localization, local necrosis, angioinvasion, and aggressive behavior are hallmarks of the disease. Ophthalmologic symptoms and signs may precede lymphoma diagnosis or complicate its disease course. We aim to define the incidence and disease pattern of ophthalmic involvement. DESIGN: Retrospective single-institution consecutive interventional case series. METHODS: Records of all lymphoma patients from 1996 to 2000 were retrieved from a computer database, and the primary sites and lineage were reviewed. Nasal T/NK lymphoma was defined by a combination of morphology, positive CD3ε and CD56 expression, in situ hybridization staining for Epstein-Barr virus expressed RNA (EBER), and negative staining for B cell markers (CD20 and CD79a). RESULTS: Thirty-five consecutive patients with T/NK lymphoma were identified. Primary nasal or nasopharyngeal disease was found in 24 patients. Six (25%) of the 24 patients suffered from vision-threatening complications of two distinct categories, namely uveitis/vitritis and orbital infiltration. The former preceded the diagnosis of lymphoma in two patients and also led to novel ocular complications like rhegmatogenous retinal detachment and macular hole that were successfully managed by ocular surgery. In four patients, orbital extension of lymphomatous disease accompanied biopsy-proven in-field disease relapse. Generally, the prognosis is grave, but remission can still be achieved with aggressive combined chemotherapy and radiotherapy. CONCLUSION: Both oncologists and ophthalmologists should be aware of ocular complications when dealing with known or suspected cases of T/NK lymphoma at diagnosis and relapse. Regular ophthalmic assessment of these patients is warranted. © 2002 by Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78308
ISSN
2015 Impact Factor: 3.831
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHon, Cen_HK
dc.contributor.authorKwok, AKHen_HK
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorChim, JCSen_HK
dc.contributor.authorAu, WYen_HK
dc.date.accessioned2010-09-06T07:41:27Z-
dc.date.available2010-09-06T07:41:27Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Ophthalmology, 2002, v. 134 n. 3, p. 406-410en_HK
dc.identifier.issn0002-9394en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78308-
dc.description.abstractPURPOSE: Nasal T/NK lineage lymphoma, previously known as lethal midline granuloma, is common among Oriental, Native-American, and Hispanic patients and is invariably associated with Epstein-Barr virus. Nasal localization, local necrosis, angioinvasion, and aggressive behavior are hallmarks of the disease. Ophthalmologic symptoms and signs may precede lymphoma diagnosis or complicate its disease course. We aim to define the incidence and disease pattern of ophthalmic involvement. DESIGN: Retrospective single-institution consecutive interventional case series. METHODS: Records of all lymphoma patients from 1996 to 2000 were retrieved from a computer database, and the primary sites and lineage were reviewed. Nasal T/NK lymphoma was defined by a combination of morphology, positive CD3ε and CD56 expression, in situ hybridization staining for Epstein-Barr virus expressed RNA (EBER), and negative staining for B cell markers (CD20 and CD79a). RESULTS: Thirty-five consecutive patients with T/NK lymphoma were identified. Primary nasal or nasopharyngeal disease was found in 24 patients. Six (25%) of the 24 patients suffered from vision-threatening complications of two distinct categories, namely uveitis/vitritis and orbital infiltration. The former preceded the diagnosis of lymphoma in two patients and also led to novel ocular complications like rhegmatogenous retinal detachment and macular hole that were successfully managed by ocular surgery. In four patients, orbital extension of lymphomatous disease accompanied biopsy-proven in-field disease relapse. Generally, the prognosis is grave, but remission can still be achieved with aggressive combined chemotherapy and radiotherapy. CONCLUSION: Both oncologists and ophthalmologists should be aware of ocular complications when dealing with known or suspected cases of T/NK lymphoma at diagnosis and relapse. Regular ophthalmic assessment of these patients is warranted. © 2002 by Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajoen_HK
dc.relation.ispartofAmerican Journal of Ophthalmologyen_HK
dc.rightsAmerican Journal of Ophthalmology. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntigens, CD3en_HK
dc.subject.meshAntigens, CD56 - immunologyen_HK
dc.subject.meshEye Neoplasms - etiology - immunology - secondaryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGranuloma, Lethal Midline - complications - immunology - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshKiller Cells, Natural - immunology - pathologyen_HK
dc.subject.meshLymphatic Metastasisen_HK
dc.subject.meshLymphoma, T-Cell - complications - immunology - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshParanasal Sinus Neoplasms - complications - immunology - pathologyen_HK
dc.subject.meshRNA-Binding Proteins - immunologyen_HK
dc.subject.meshReceptors, Antigen, T-Cell - immunologyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRibosomal Proteinsen_HK
dc.subject.meshVision Disorders - diagnosis - etiology - immunologyen_HK
dc.titleVision-threatening complications of nasal T/NK lymphomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9394&volume=134&spage=406&epage=410&date=2002&atitle=Vision-threatening+complications+of+nasal+T/NK+lymphomaen_HK
dc.identifier.emailChim, JCS:jcschim@hku.hken_HK
dc.identifier.authorityChim, JCS=rp00408en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9394(02)01520-9en_HK
dc.identifier.pmid12208253-
dc.identifier.scopuseid_2-s2.0-0036742970en_HK
dc.identifier.hkuros77920en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036742970&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume134en_HK
dc.identifier.issue3en_HK
dc.identifier.spage406en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000177660300013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHon, C=7003617146en_HK
dc.identifier.scopusauthoridKwok, AKH=7005913424en_HK
dc.identifier.scopusauthoridShek, TWH=7005479861en_HK
dc.identifier.scopusauthoridChim, JCS=7004597253en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK

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