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Article: Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils

TitleEffects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils
Authors
KeywordsApoptosis
Aspirin
Cell proliferation
H. pylori infection
Heterotopic proliferative glands
Inflammation
Issue Date2008
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HEL
Citation
Helicobacter, 2008, v. 13 n. 1, p. 20-29 How to Cite?
AbstractBackground: Helicobacter pylori infection is a major cause of gastritis and gastric carcinoma. Aspirin has anti-inflammatory and antineoplastic activity. The aim of the present study was to determine the effects of aspirin on H. pylori-induced gastritis and the development of heterotopic proliferative glands. Methods: H. pylori strain SS1 was inoculated into the stomachs of Mongolian gerbils. Two weeks after inoculation, the animals were fed with the powder diets containing 0 p.p.m. (n = 10), 150 p.p.m. (n = 10), or 500 p.p.m. (n = 10) aspirin. Mongolian gerbils were killed after 36 weeks of infection. Uninfected Mongolian gerbils (n = 10) were used as controls. Histologic changes, epithelial cell proliferation and apoptosis, and prostaglandin E2 (PGE2) levels of gastric tissue were determined. Results: H. pylori infection induced gastric inflammation. Administration of aspirin did not change H. pylori-induced gastritis, but alleviated H. pylori-induced hyperplasia and the development of heterotopic proliferative glands. Administration of aspirin accelerated H. pylori-associated apoptosis but decreased H. pylori-associated cell proliferation. In addition, the increased gastric PGE2 levels due to H. pylori infection were suppressed by treatment with aspirin, especially at the dose of 500 p.p.m. Conclusions: Aspirin alleviates H. pylori-induced hyperplasia and the development of heterotopic proliferative glands. Moreover, aspirin increases H. pylori-induced apoptosis. We demonstrated the antineoplastic activities of aspirin in H. pylori-related gastric carcinogenesis. © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/78299
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.131
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, GQen_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorChen, MHen_HK
dc.contributor.authorTsukamoto, Ten_HK
dc.contributor.authorTatematsu, Men_HK
dc.contributor.authorGu, Qen_HK
dc.contributor.authorQiao, Len_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorSo, WHLen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorHu, PJen_HK
dc.contributor.authorLiang, YJen_HK
dc.contributor.authorLin, HLen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:41:21Z-
dc.date.available2010-09-06T07:41:21Z-
dc.date.issued2008en_HK
dc.identifier.citationHelicobacter, 2008, v. 13 n. 1, p. 20-29en_HK
dc.identifier.issn1083-4389en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78299-
dc.description.abstractBackground: Helicobacter pylori infection is a major cause of gastritis and gastric carcinoma. Aspirin has anti-inflammatory and antineoplastic activity. The aim of the present study was to determine the effects of aspirin on H. pylori-induced gastritis and the development of heterotopic proliferative glands. Methods: H. pylori strain SS1 was inoculated into the stomachs of Mongolian gerbils. Two weeks after inoculation, the animals were fed with the powder diets containing 0 p.p.m. (n = 10), 150 p.p.m. (n = 10), or 500 p.p.m. (n = 10) aspirin. Mongolian gerbils were killed after 36 weeks of infection. Uninfected Mongolian gerbils (n = 10) were used as controls. Histologic changes, epithelial cell proliferation and apoptosis, and prostaglandin E2 (PGE2) levels of gastric tissue were determined. Results: H. pylori infection induced gastric inflammation. Administration of aspirin did not change H. pylori-induced gastritis, but alleviated H. pylori-induced hyperplasia and the development of heterotopic proliferative glands. Administration of aspirin accelerated H. pylori-associated apoptosis but decreased H. pylori-associated cell proliferation. In addition, the increased gastric PGE2 levels due to H. pylori infection were suppressed by treatment with aspirin, especially at the dose of 500 p.p.m. Conclusions: Aspirin alleviates H. pylori-induced hyperplasia and the development of heterotopic proliferative glands. Moreover, aspirin increases H. pylori-induced apoptosis. We demonstrated the antineoplastic activities of aspirin in H. pylori-related gastric carcinogenesis. © 2008 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HELen_HK
dc.relation.ispartofHelicobacteren_HK
dc.subjectApoptosisen_HK
dc.subjectAspirinen_HK
dc.subjectCell proliferationen_HK
dc.subjectH. pylori infectionen_HK
dc.subjectHeterotopic proliferative glandsen_HK
dc.subjectInflammationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Inflammatory Agents - administration & dosage - pharmacologyen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshAspirin - administration & dosage - pharmacologyen_HK
dc.subject.meshChoristoma - pathology - prevention & controlen_HK
dc.subject.meshDinoprostone - analysisen_HK
dc.subject.meshEpithelial Cells - pathologyen_HK
dc.subject.meshGastric Mucosa - chemistry - drug effects - pathologyen_HK
dc.subject.meshGerbillinaeen_HK
dc.subject.meshHelicobacter Infections - microbiology - pathologyen_HK
dc.subject.meshHelicobacter pylori - physiologyen_HK
dc.subject.meshHyperplasia - prevention & controlen_HK
dc.subject.meshInflammation - pathology - prevention & controlen_HK
dc.subject.meshMaleen_HK
dc.titleEffects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbilsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1083-4389&volume=13&spage=20&epage=9&date=2008&atitle=Effects+of+aspirin+on+the+development+of+Helicobacter+pylori-induced+gastric+inflammation+and+heterotopic+proliferative+glands+in+Mongolian+gerbilsen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1523-5378.2008.00585.xen_HK
dc.identifier.pmid18205662-
dc.identifier.scopuseid_2-s2.0-38149120253en_HK
dc.identifier.hkuros141377en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38149120253&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue1en_HK
dc.identifier.spage20en_HK
dc.identifier.epage29en_HK
dc.identifier.isiWOS:000252396400002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, GQ=8692805500en_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridChen, MH=8642044500en_HK
dc.identifier.scopusauthoridTsukamoto, T=7401493786en_HK
dc.identifier.scopusauthoridTatematsu, M=7101635652en_HK
dc.identifier.scopusauthoridGu, Q=24469982400en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK
dc.identifier.scopusauthoridSo, WHL=7004974020en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridHu, PJ=7201989582en_HK
dc.identifier.scopusauthoridLiang, YJ=12804573800en_HK
dc.identifier.scopusauthoridLin, HL=8950219500en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.citeulike2249450-

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