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Article: Identification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chinese

TitleIdentification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chinese
Authors
KeywordsBone mineral density
Genetics
Linkage
Osteoporosis
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation
Human Heredity, 2006, v. 61 n. 4, p. 237-243 How to Cite?
AbstractBackground: Chromosome 11q has not only been found to contain mutations responsible for the several Mendelian disorders of the skeleton, but it has also been linked to bone mineral density (BMD) variation in several genome-wide linkage studies. Furthermore, quantitative trait loci (QTL) affecting BMD in inbred mice and baboons have been mapped to a region syntenic to human chromosome 11q. The aim of the present study is to determine whether there is a QTL for BMD variation on chromosome 11q in the Chinese population. Methods: Nineteen microsatellite markers were genotyped for a 75 cM region on 11q13-25 in 306 Chinese families with 1,459 subjects. BMD (g/cm 2) was measured by DXA. Linkage analyses were performed using the variance component linkage analysis method implemented in Merlin software. Results: For women, a maximum LOD score of 1.62 was achieved at 90.8 cM on 11q21 near the marker D11S4175 for femoral neck BMD; LOD scores greater than 1.0 were observed on 11q13 for trochanter BMD. For men, a maximum LOD score of 1.57 was achieved at 135.8 cM on 11q24 near the marker D11S4126 for total hip BMD. Conclusion: We have not only replicated the previous linkage finding on chromosome 11q but also identified two sex-specific QTL that contribute to BMD variation in Chinese women and men. Copyright © 2006 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/78273
ISSN
2015 Impact Factor: 1.539
2015 SCImago Journal Rankings: 0.942
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, QYen_HK
dc.contributor.authorNg, MYMen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:41:03Z-
dc.date.available2010-09-06T07:41:03Z-
dc.date.issued2006en_HK
dc.identifier.citationHuman Heredity, 2006, v. 61 n. 4, p. 237-243en_HK
dc.identifier.issn0001-5652en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78273-
dc.description.abstractBackground: Chromosome 11q has not only been found to contain mutations responsible for the several Mendelian disorders of the skeleton, but it has also been linked to bone mineral density (BMD) variation in several genome-wide linkage studies. Furthermore, quantitative trait loci (QTL) affecting BMD in inbred mice and baboons have been mapped to a region syntenic to human chromosome 11q. The aim of the present study is to determine whether there is a QTL for BMD variation on chromosome 11q in the Chinese population. Methods: Nineteen microsatellite markers were genotyped for a 75 cM region on 11q13-25 in 306 Chinese families with 1,459 subjects. BMD (g/cm 2) was measured by DXA. Linkage analyses were performed using the variance component linkage analysis method implemented in Merlin software. Results: For women, a maximum LOD score of 1.62 was achieved at 90.8 cM on 11q21 near the marker D11S4175 for femoral neck BMD; LOD scores greater than 1.0 were observed on 11q13 for trochanter BMD. For men, a maximum LOD score of 1.57 was achieved at 135.8 cM on 11q24 near the marker D11S4126 for total hip BMD. Conclusion: We have not only replicated the previous linkage finding on chromosome 11q but also identified two sex-specific QTL that contribute to BMD variation in Chinese women and men. Copyright © 2006 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHEen_HK
dc.relation.ispartofHuman Heredityen_HK
dc.rightsHuman Heredity. Copyright © S Karger AG.en_HK
dc.subjectBone mineral densityen_HK
dc.subjectGeneticsen_HK
dc.subjectLinkageen_HK
dc.subjectOsteoporosisen_HK
dc.subject.meshBone Density - genetics - physiologyen_HK
dc.subject.meshChinaen_HK
dc.subject.meshChromosomes, Human, Pair 11en_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFemur - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPelvic Bones - metabolismen_HK
dc.subject.meshQuantitative Trait Locien_HK
dc.titleIdentification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0001-5652&volume=61&issue=4&spage=237&epage=243&date=2006&atitle=Identification+of+two+sex-specific+quantitative+trait+loci+in+chromosome+11q+for+hip+bone+mineral+density+in+Chineseen_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1159/000095216en_HK
dc.identifier.pmid16926538en_HK
dc.identifier.scopuseid_2-s2.0-33748488842en_HK
dc.identifier.hkuros133770en_HK
dc.identifier.hkuros121335-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748488842&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue4en_HK
dc.identifier.spage237en_HK
dc.identifier.epage243en_HK
dc.identifier.isiWOS:000240438800006-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.scopusauthoridNg, MYM=8367886400en_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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