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Article: Fibrolamellar hepatocellular carcinoma

TitleFibrolamellar hepatocellular carcinoma
Authors
KeywordsMedical sciences
Gastroenterology
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2009, v. 104 n. 10, p. 2617-2624 How to Cite?
AbstractFibrolamellar hepatocellular carcinoma (FHLCC) generally occurs in young individuals lacking a background of chronic liver disease and other risk factors for hepatocellular carcinoma. The clinical presentations of FLHCC are generally nonspecific, and the α-fetoprotein level is typically within the normal range in most cases. Imaging studies have a major role in clinical diagnosis, but pathology is the gold standard in confirming diagnosis. Pathological characteristics of FLHCC include the presence of tumor cells with a deeply eosinophilic cytoplasm and macronucleoli surrounded by abundant fibrous bands. The most effective treatment for FLHCC is aggressive surgical resection. This comprehensive literature review gives a full account of the clinical, pathological, and molecular features of FLHCC.
Persistent Identifierhttp://hdl.handle.net/10722/78253
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
Funding AgencyGrant Number
Seed Funding Program for Basic Research of the University of Hong Kong200711159034
Funding Information:

is study was supported in part by the Seed Funding Program for Basic Research of the University of Hong Kong ( grant code 200711159034).

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Sen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorWang, Ben_HK
dc.contributor.authorQiao, Len_HK
dc.date.accessioned2010-09-06T07:40:50Z-
dc.date.available2010-09-06T07:40:50Z-
dc.date.issued2009en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 2009, v. 104 n. 10, p. 2617-2624en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78253-
dc.description.abstractFibrolamellar hepatocellular carcinoma (FHLCC) generally occurs in young individuals lacking a background of chronic liver disease and other risk factors for hepatocellular carcinoma. The clinical presentations of FLHCC are generally nonspecific, and the α-fetoprotein level is typically within the normal range in most cases. Imaging studies have a major role in clinical diagnosis, but pathology is the gold standard in confirming diagnosis. Pathological characteristics of FLHCC include the presence of tumor cells with a deeply eosinophilic cytoplasm and macronucleoli surrounded by abundant fibrous bands. The most effective treatment for FLHCC is aggressive surgical resection. This comprehensive literature review gives a full account of the clinical, pathological, and molecular features of FLHCC.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subjectMedical sciences-
dc.subjectGastroenterology-
dc.subject.meshCarcinoma, Hepatocellular - diagnosis - genetics - pathology - therapyen_HK
dc.subject.meshDiagnosis, Differentialen_HK
dc.subject.meshDiagnostic Imagingen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - diagnosis - genetics - pathology - therapyen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleFibrolamellar hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9270&volume=104&issue=10&spage=2617&epage=2624&date=2009&atitle=Fibrolamellar+hepatocellular+carcinomaen_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajg.2009.440en_HK
dc.identifier.pmid19638962-
dc.identifier.scopuseid_2-s2.0-70350492933en_HK
dc.identifier.hkuros174357en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350492933&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2617en_HK
dc.identifier.epage2624en_HK
dc.identifier.isiWOS:000270853300030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, S=27171024700en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridWang, B=8548541700en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK

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