File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A simple assessment of peritoneal transport in stable continuous ambulatory peritoneal dialysis patients

TitleA simple assessment of peritoneal transport in stable continuous ambulatory peritoneal dialysis patients
Authors
KeywordsCAPD
D/P
Glucose transport
MTACCr
MTACGlu
Peritoneal transport
Issue Date1998
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/AJN
Citation
American Journal Of Nephrology, 1998, v. 18 n. 4, p. 311-317 How to Cite?
AbstractWe studied the peritoneal transport properties in 175 stable continuous ambulatory peritoneal dialysis (CAPD) patients seeking a simple and handy assessment of peritoneal permeability to small solutes. Measurement of creatinine in biological fluid was known to suffer from interference by high glucose concentration in the sample. Furthermore, the interference is also affected by the creatinine concentration of the specimen. Peritoneal transport properties were studied by determining the dialysate to plasma ratio of creatinine concentration (D/P) at the fourth hour of the peritoneal equilibration test, and the mass transfer area coefficient of creatinine (MTACCr) or glucose (MTACGlu). The ratio of glucose concentration in peritoneal dialysate effluent (PDE) at 4 and 0 h (G4/G0) was examined and compared with various peritoneal parameters. There were significant logarithmic correlations between D/P or G4/G0 with MTACCr (r = 0.96 and 0.79, respectively, p < 0.0001). The correlation between G4/G0 and D/P was linear (r = -0.82, p < 0.0001). A fairly good agreement was present between G4/G0 and D/P by Bland and Altman's method. The bias was -0.93% with 95% confidence interval -23.29% to 21.43% of the measured value. Systematic error was found when D/P or G4/G0 were compared with MTACCr. D/P under estimated MTACCr in the high range. The reverse happened for G4/G0. Net ultrafiltration (NUF) also correlated with MTACCr, D/P and G4/G0 (r = -0.32, p < 0.001; -0.26, p < 0.01; and 0.16, p < 0.05, respectively. In conclusion, the use of G4/G0 as a measure of peritoneal transport in CAPD is an acceptable alternative to D/P. It is highly reproducible and avoids correction of interference when creatinine transport parameters are measured. Because of the logarithmic relations of G4/G0 (or D/P) with MTACCr, the former should not be directly converted to MTACCr. Such a simple measure of peritoneal permeability is, however, most convenient for serial monitoring and can be useful to detect early loss of ultrafiltration or solute clearance.
Persistent Identifierhttp://hdl.handle.net/10722/78239
ISSN
2015 Impact Factor: 2.605
2015 SCImago Journal Rankings: 1.308
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorSzeto, CCen_HK
dc.contributor.authorHo, KKLen_HK
dc.contributor.authorYu, AWYen_HK
dc.contributor.authorMak, TWen_HK
dc.contributor.authorLam, CWKen_HK
dc.date.accessioned2010-09-06T07:40:41Z-
dc.date.available2010-09-06T07:40:41Z-
dc.date.issued1998en_HK
dc.identifier.citationAmerican Journal Of Nephrology, 1998, v. 18 n. 4, p. 311-317en_HK
dc.identifier.issn0250-8095en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78239-
dc.description.abstractWe studied the peritoneal transport properties in 175 stable continuous ambulatory peritoneal dialysis (CAPD) patients seeking a simple and handy assessment of peritoneal permeability to small solutes. Measurement of creatinine in biological fluid was known to suffer from interference by high glucose concentration in the sample. Furthermore, the interference is also affected by the creatinine concentration of the specimen. Peritoneal transport properties were studied by determining the dialysate to plasma ratio of creatinine concentration (D/P) at the fourth hour of the peritoneal equilibration test, and the mass transfer area coefficient of creatinine (MTACCr) or glucose (MTACGlu). The ratio of glucose concentration in peritoneal dialysate effluent (PDE) at 4 and 0 h (G4/G0) was examined and compared with various peritoneal parameters. There were significant logarithmic correlations between D/P or G4/G0 with MTACCr (r = 0.96 and 0.79, respectively, p < 0.0001). The correlation between G4/G0 and D/P was linear (r = -0.82, p < 0.0001). A fairly good agreement was present between G4/G0 and D/P by Bland and Altman's method. The bias was -0.93% with 95% confidence interval -23.29% to 21.43% of the measured value. Systematic error was found when D/P or G4/G0 were compared with MTACCr. D/P under estimated MTACCr in the high range. The reverse happened for G4/G0. Net ultrafiltration (NUF) also correlated with MTACCr, D/P and G4/G0 (r = -0.32, p < 0.001; -0.26, p < 0.01; and 0.16, p < 0.05, respectively. In conclusion, the use of G4/G0 as a measure of peritoneal transport in CAPD is an acceptable alternative to D/P. It is highly reproducible and avoids correction of interference when creatinine transport parameters are measured. Because of the logarithmic relations of G4/G0 (or D/P) with MTACCr, the former should not be directly converted to MTACCr. Such a simple measure of peritoneal permeability is, however, most convenient for serial monitoring and can be useful to detect early loss of ultrafiltration or solute clearance.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/AJNen_HK
dc.relation.ispartofAmerican Journal of Nephrologyen_HK
dc.rightsAmerican Journal of Nephrology. Copyright © S Karger AG.en_HK
dc.subjectCAPDen_HK
dc.subjectD/Pen_HK
dc.subjectGlucose transporten_HK
dc.subjectMTACCren_HK
dc.subjectMTACGluen_HK
dc.subjectPeritoneal transporten_HK
dc.titleA simple assessment of peritoneal transport in stable continuous ambulatory peritoneal dialysis patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0250-8095&volume=18&spage=311&epage=317&date=1998&atitle=A+simple+assessment+of+peritoneal+transport+in+stable+continuous+ambulatory+peritoneal+dialysis+patientsen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000013356en_HK
dc.identifier.pmid9653835-
dc.identifier.scopuseid_2-s2.0-0031745669en_HK
dc.identifier.hkuros41505en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031745669&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue4en_HK
dc.identifier.spage311en_HK
dc.identifier.epage317en_HK
dc.identifier.isiWOS:000074225200008-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridSzeto, CC=35495407200en_HK
dc.identifier.scopusauthoridHo, KKL=15850509100en_HK
dc.identifier.scopusauthoridYu, AWY=7401478900en_HK
dc.identifier.scopusauthoridMak, TW=8446415900en_HK
dc.identifier.scopusauthoridLam, CWK=8531362100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats