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Article: Qualitative and quantitative magnetic resonance imaging in haemoglobin H disease: Screening for iron overload

TitleQualitative and quantitative magnetic resonance imaging in haemoglobin H disease: Screening for iron overload
Authors
Issue Date1999
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/crad
Citation
Clinical Radiology, 1999, v. 54 n. 2, p. 98-102 How to Cite?
AbstractOBJECTIVES: To evaluate the clinical utility of magnetic resonance imaging (MRI) in screening for iron overload in non-transfusion dependent Haemoglobin (Hb) H disease. PATIENTS AND METHODS: Thirty-six non-transfusion dependent HbH patients were evaluated with axial spin echo T1 and gradient echo T2 MRI of the abdomen and heart. The ratios of signal intensities (SIR) of the liver, spleen, pancreas and heart to paraspinous muscles were calculated. SIR < 1 was taken as indicative of iron overload. Qualitative grading (0-4 scale) of iron overload was also performed. The relationship between T1 and T2 SIR and serum ferritin, and that between qualitative grading and serum ferritin were examined using standard statistical methods. Comparisons were also made between qualitative grading and quantitative T1 and T2 SIR data in diagnosing iron overload. Six patients underwent liver biopsies. RESULTS: T2 SIR was more sensitive in detecting iron overload than T1 SIR. Thirty-three livers, 13 spleens, six pancreas and one heart were diagnosed as having iron overload with T2 SIR, including three patients with normal serum ferritin. A positive diagnosis by T2 SIR was more closely related to that of qualitative grading than T1 SIR. Serum ferritin was negatively correlated with hepatic SIR (T1 and T2), and with T2 SIR of the spleen and pancreas, even after adjustment for age. Liver haemosiderosis was confirmed in all six patients who underwent liver biopsies. Liver iron concentration of only one and a half times the normal was found in one patient with positive MR findings. CONCLUSION: MR is a non-invasive, effective method for early detection of iron overload particularly in the liver and spleen. Qualitative grading and quantitative T2 SIR data are equivalent in diagnosing iron overload. Routine screening of non-transfusion dependent HbH patients will identify high risk patients in whom early therapeutic intervention may prevent further complications and morbidity.
Persistent Identifierhttp://hdl.handle.net/10722/78201
ISSN
2015 Impact Factor: 2.151
2015 SCImago Journal Rankings: 0.864
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorChen, FEen_HK
dc.contributor.authorChan, KNen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorWong, YHen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorNgan, Hen_HK
dc.date.accessioned2010-09-06T07:40:16Z-
dc.date.available2010-09-06T07:40:16Z-
dc.date.issued1999en_HK
dc.identifier.citationClinical Radiology, 1999, v. 54 n. 2, p. 98-102en_HK
dc.identifier.issn0009-9260en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78201-
dc.description.abstractOBJECTIVES: To evaluate the clinical utility of magnetic resonance imaging (MRI) in screening for iron overload in non-transfusion dependent Haemoglobin (Hb) H disease. PATIENTS AND METHODS: Thirty-six non-transfusion dependent HbH patients were evaluated with axial spin echo T1 and gradient echo T2 MRI of the abdomen and heart. The ratios of signal intensities (SIR) of the liver, spleen, pancreas and heart to paraspinous muscles were calculated. SIR < 1 was taken as indicative of iron overload. Qualitative grading (0-4 scale) of iron overload was also performed. The relationship between T1 and T2 SIR and serum ferritin, and that between qualitative grading and serum ferritin were examined using standard statistical methods. Comparisons were also made between qualitative grading and quantitative T1 and T2 SIR data in diagnosing iron overload. Six patients underwent liver biopsies. RESULTS: T2 SIR was more sensitive in detecting iron overload than T1 SIR. Thirty-three livers, 13 spleens, six pancreas and one heart were diagnosed as having iron overload with T2 SIR, including three patients with normal serum ferritin. A positive diagnosis by T2 SIR was more closely related to that of qualitative grading than T1 SIR. Serum ferritin was negatively correlated with hepatic SIR (T1 and T2), and with T2 SIR of the spleen and pancreas, even after adjustment for age. Liver haemosiderosis was confirmed in all six patients who underwent liver biopsies. Liver iron concentration of only one and a half times the normal was found in one patient with positive MR findings. CONCLUSION: MR is a non-invasive, effective method for early detection of iron overload particularly in the liver and spleen. Qualitative grading and quantitative T2 SIR data are equivalent in diagnosing iron overload. Routine screening of non-transfusion dependent HbH patients will identify high risk patients in whom early therapeutic intervention may prevent further complications and morbidity.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/craden_HK
dc.relation.ispartofClinical Radiologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFerritins - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshIron Overload - blood - diagnosis - etiologyen_HK
dc.subject.meshLiver - pathologyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMass Screening - methodsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMyocardium - pathologyen_HK
dc.subject.meshPancreas - pathologyen_HK
dc.subject.meshSpleen - pathologyen_HK
dc.subject.meshalpha-Thalassemia - complicationsen_HK
dc.titleQualitative and quantitative magnetic resonance imaging in haemoglobin H disease: Screening for iron overloaden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-9260&volume=54&issue=2&spage=98&epage=102&date=1999&atitle=Qualitative+and+quantitative+magnetic+resonance+imaging+in+haemoglobin+H+disease:+screening+for+iron+overloaden_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0009-9260(99)91068-1en_HK
dc.identifier.pmid10050737-
dc.identifier.scopuseid_2-s2.0-0032986701en_HK
dc.identifier.hkuros44841en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032986701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue2en_HK
dc.identifier.spage98en_HK
dc.identifier.epage102en_HK
dc.identifier.isiWOS:000078471600007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridChen, FE=17934080100en_HK
dc.identifier.scopusauthoridChan, KN=15737866400en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridWong, YH=24073787400en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridNgan, H=7102173824en_HK

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