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Article: Concurrent mediastinal B cell lymphoma and chronic myeloid leukemia with an unusually favorable response to chemotherapy

TitleConcurrent mediastinal B cell lymphoma and chronic myeloid leukemia with an unusually favorable response to chemotherapy
Authors
Issue Date2003
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2003, v. 44 n. 3, p. 535-538 How to Cite?
AbstractA 67-year-old Chinese woman presented with mediastinal B cell lymphoma in 1992 with incidental leukocytosis. Bone marrow and peripheral blood findings confirmed the diagnosis of chronic myeloid leukemia (CML). After combination chemotherapy and radiotherapy for lymphoma, her peripheral blood counts remained normal, and she refused further treatment for nearly six years. Frank hematologic relapse occurred in 1998 and low dose hydroxyurea was used, which was stopped after six months owing to cytopenia. She remained well without treatment at 12-year follow up. Retrospective Southern blot analysis confirmed BCR gene rearrangement in marrow in 1992 and 1998, but not in the lymphoma or the latest peripheral blood. Fluorescence in-situ hybridzation analysis showed no Philadelphia chromosome positive (Ph +) cells in the peripheral blood at last (FISH) follow-up, but BCR/ABL remained detectable. The relevance of the concomitant occurrence of CML and lymphoma and the unusually favorable response of CML to chemotherapy to the pathogenesis of CML is discussed.
Persistent Identifierhttp://hdl.handle.net/10722/78191
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorWan, TSen_HK
dc.contributor.authorWang, EPen_HK
dc.contributor.authorLau, TCMen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:40:10Z-
dc.date.available2010-09-06T07:40:10Z-
dc.date.issued2003en_HK
dc.identifier.citationLeukemia And Lymphoma, 2003, v. 44 n. 3, p. 535-538en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78191-
dc.description.abstractA 67-year-old Chinese woman presented with mediastinal B cell lymphoma in 1992 with incidental leukocytosis. Bone marrow and peripheral blood findings confirmed the diagnosis of chronic myeloid leukemia (CML). After combination chemotherapy and radiotherapy for lymphoma, her peripheral blood counts remained normal, and she refused further treatment for nearly six years. Frank hematologic relapse occurred in 1998 and low dose hydroxyurea was used, which was stopped after six months owing to cytopenia. She remained well without treatment at 12-year follow up. Retrospective Southern blot analysis confirmed BCR gene rearrangement in marrow in 1992 and 1998, but not in the lymphoma or the latest peripheral blood. Fluorescence in-situ hybridzation analysis showed no Philadelphia chromosome positive (Ph +) cells in the peripheral blood at last (FISH) follow-up, but BCR/ABL remained detectable. The relevance of the concomitant occurrence of CML and lymphoma and the unusually favorable response of CML to chemotherapy to the pathogenesis of CML is discussed.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - therapeutic useen_HK
dc.subject.meshClone Cells - pathologyen_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshCyclophosphamide - administration & dosageen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFusion Proteins, bcr-abl - analysis - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydroxyurea - therapeutic useen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics - pathologyen_HK
dc.subject.meshLeukocytosis - etiologyen_HK
dc.subject.meshLymphoma, B-Cell - drug therapy - genetics - pathology - radiotherapyen_HK
dc.subject.meshMediastinal Neoplasms - drug therapy - genetics - pathology - radiotherapyen_HK
dc.subject.meshNeoplasms, Multiple Primary - geneticsen_HK
dc.subject.meshPrednisolone - administration & dosageen_HK
dc.subject.meshProcarbazine - administration & dosageen_HK
dc.subject.meshRemission Inductionen_HK
dc.subject.meshTumor Markers, Biological - analysis - geneticsen_HK
dc.subject.meshVincristine - administration & dosageen_HK
dc.titleConcurrent mediastinal B cell lymphoma and chronic myeloid leukemia with an unusually favorable response to chemotherapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=44&spage=535&epage=538&date=2003&atitle=Concurrent+mediastinal+B+cell+lymphoma+and+chronic+myeloid+leukemia+with+an+unusually+favorable+response+to+chemotherapyen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/1042819021000038029en_HK
dc.identifier.pmid12688328-
dc.identifier.scopuseid_2-s2.0-0037346935en_HK
dc.identifier.hkuros77872en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037346935&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue3en_HK
dc.identifier.spage535en_HK
dc.identifier.epage538en_HK
dc.identifier.isiWOS:000179750500021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridWan, TS=25623981600en_HK
dc.identifier.scopusauthoridWang, EP=7403414620en_HK
dc.identifier.scopusauthoridLau, TCM=17341008600en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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