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Article: B-cell small lymphocytic lymphoma with circulating granular prolymphocytes and a novel trisomy 15 anomaly

TitleB-cell small lymphocytic lymphoma with circulating granular prolymphocytes and a novel trisomy 15 anomaly
Authors
Issue Date1995
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1995, v. 81 n. 1, p. 28-32 How to Cite?
AbstractA 53-year-old man presented with cervical lymphadenopathy and massive splenomegaly. Peripheral blood examination showed many prolymphocytes with cytoplasmic azurophilic granules, giving an initial impression of large granular lymphocytosis. The lymph node biopsy and immunohistochemical study findings, however, were more compatible with a diagnosis of B-cell small lymphocytic lymphoma. The circulating prolymphocytes showed restricted kappa light chain expression similar to the lymphoid infiltrate in the lymph node. Karyotypic analysis revealed trisomy 15, a chromosomal abnormality that has rarely been described in small lymphocytic lymphoma or chronic lymphocytic leukemia.
Persistent Identifierhttp://hdl.handle.net/10722/78184
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChan, JKCen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorSin, VCen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorTang, KCen_HK
dc.date.accessioned2010-09-06T07:40:05Z-
dc.date.available2010-09-06T07:40:05Z-
dc.date.issued1995en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1995, v. 81 n. 1, p. 28-32en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78184-
dc.description.abstractA 53-year-old man presented with cervical lymphadenopathy and massive splenomegaly. Peripheral blood examination showed many prolymphocytes with cytoplasmic azurophilic granules, giving an initial impression of large granular lymphocytosis. The lymph node biopsy and immunohistochemical study findings, however, were more compatible with a diagnosis of B-cell small lymphocytic lymphoma. The circulating prolymphocytes showed restricted kappa light chain expression similar to the lymphoid infiltrate in the lymph node. Karyotypic analysis revealed trisomy 15, a chromosomal abnormality that has rarely been described in small lymphocytic lymphoma or chronic lymphocytic leukemia.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshBone Marrow - pathology - ultrastructureen_HK
dc.subject.meshChromosomes, Human, Pair 15en_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunophenotypingen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - blood - genetics - pathologyen_HK
dc.subject.meshLymph Nodes - pathologyen_HK
dc.subject.meshLymphocytes - pathology - ultrastructureen_HK
dc.subject.meshLymphoma, B-Cell - blood - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTrisomy - geneticsen_HK
dc.titleB-cell small lymphocytic lymphoma with circulating granular prolymphocytes and a novel trisomy 15 anomalyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=81&spage=28&epage=32&date=1995&atitle=B-cell+small+lymphocytic+lymphoma+with+circulating+granular+prolymphocytes+and+a+novel+trisomy+15+anomalyen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0165-4608(94)00200-2en_HK
dc.identifier.pmid7773956-
dc.identifier.scopuseid_2-s2.0-0029013604en_HK
dc.identifier.hkuros5621en_HK
dc.identifier.volume81en_HK
dc.identifier.issue1en_HK
dc.identifier.spage28en_HK
dc.identifier.epage32en_HK
dc.identifier.isiWOS:A1995RE02400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChan, JKC=7403287069en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridSin, VC=6603540694en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridTang, KC=25935272600en_HK

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