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Article: Effects of {2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose} on human hepatocellular carcinoma cell line

TitleEffects of {2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose} on human hepatocellular carcinoma cell line
Authors
KeywordsApoptosis
Hepatoma
HepG2
2-[(3-carboxy-1-oxoprogyl)amino]-2-deoxy-D- glucose
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2005, v. 26 n. 5, p. 635-640 How to Cite?
AbstractAim: To study the effects of {2-[(3-carboxy-1-oxoprogyl)amino]-2-deoxy-D- glucose (COPADG) on cultured human hepatocellular carcinoma cells (HepG2). Methods: HepG2 cells were cultured in RPMI-1640 medium. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μmol/L, COPADG potently inhibited the growth and induced apoptosis of HepG2 cells. Conclusion: COPADG could effectively induce apoptosis in human hepatocellular carcinoma cells. More investigations are warranted for the potential use of this compound as a new agent for the non-surgical management of human hepatocellular carcinoma. ©2005 CPS and SIMM.
Persistent Identifierhttp://hdl.handle.net/10722/78182
ISSN
2015 Impact Factor: 3.166
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, Jen_HK
dc.contributor.authorKou, Wen_HK
dc.contributor.authorGao, MTen_HK
dc.contributor.authorZhou, YNen_HK
dc.contributor.authorWang, AQen_HK
dc.contributor.authorXue, QJen_HK
dc.contributor.authorQiao, Len_HK
dc.date.accessioned2010-09-06T07:40:04Z-
dc.date.available2010-09-06T07:40:04Z-
dc.date.issued2005en_HK
dc.identifier.citationActa Pharmacologica Sinica, 2005, v. 26 n. 5, p. 635-640en_HK
dc.identifier.issn1671-4083en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78182-
dc.description.abstractAim: To study the effects of {2-[(3-carboxy-1-oxoprogyl)amino]-2-deoxy-D- glucose (COPADG) on cultured human hepatocellular carcinoma cells (HepG2). Methods: HepG2 cells were cultured in RPMI-1640 medium. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μmol/L, COPADG potently inhibited the growth and induced apoptosis of HepG2 cells. Conclusion: COPADG could effectively induce apoptosis in human hepatocellular carcinoma cells. More investigations are warranted for the potential use of this compound as a new agent for the non-surgical management of human hepatocellular carcinoma. ©2005 CPS and SIMM.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.htmlen_HK
dc.relation.ispartofActa Pharmacologica Sinicaen_HK
dc.subjectApoptosisen_HK
dc.subjectHepatomaen_HK
dc.subjectHepG2en_HK
dc.subject2-[(3-carboxy-1-oxoprogyl)amino]-2-deoxy-D- glucoseen_HK
dc.titleEffects of {2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose} on human hepatocellular carcinoma cell lineen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1671-4083&volume=26&spage=635&epage=640&date=2005&atitle=Effects+of+{2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose}+on+human+hepatocellular+carcinoma+cell+lineen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1745-7254.2005.00066.xen_HK
dc.identifier.pmid15842786-
dc.identifier.scopuseid_2-s2.0-18744399885en_HK
dc.identifier.hkuros132398en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18744399885&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue5en_HK
dc.identifier.spage635en_HK
dc.identifier.epage640en_HK
dc.identifier.isiWOS:000229103500021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, J=7409254006en_HK
dc.identifier.scopusauthoridKou, W=36800461200en_HK
dc.identifier.scopusauthoridGao, MT=25629672200en_HK
dc.identifier.scopusauthoridZhou, YN=7405364644en_HK
dc.identifier.scopusauthoridWang, AQ=7404620465en_HK
dc.identifier.scopusauthoridXue, QJ=36071456600en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK

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