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Article: Stability of E-cadherin methylation status in gastric mucosa associated with histology changes

TitleStability of E-cadherin methylation status in gastric mucosa associated with histology changes
Authors
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2006, v. 24 n. 5, p. 831-836 How to Cite?
AbstractBackground: We have previously shown reversal of E-cadherin methylation in gastric mucosa from patients with dyspepsia at week 6 after Helicobacter pylori-eradication therapy. But the long-term methylation status of these patients was unknown. Aim: To investigate the methylation status at E-cadherin at year 3 after H. pylori-eradication therapy. Methods: 35 patients (25 with and 10 without H. pylori eradicated) enrolled in our previous study were recruited into the present study (year 3 analysis). Methylation at E-cadherin was evaluated by methylation-specific polymerase chain reaction method. Results: There was no difference in age and sex distribution in the two groups. Methylation at E-cadherin in patients with H. pylori eradicated at weeks 0, 6 and year 3 were 52%, 20% and 20%, respectively. Concordant methylation status at week 6 and year 3 was 92%. Methylation at E-cadherin in patients without H. pylori at weeks 0, 6 and year 3 were 50%, 60% and 60%, respectively. Concordant methylation status between week 6 and year 3 was 90%. Stability of E-cadherin methylation status was associated with histological changes. No association between E-cadherin methylation status and age was observed. Conclusion: The methylation pattern is stable for a long period, thus suggesting the effect of environment on methylation. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/78141
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorHuang, Cen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorRashid, Aen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:39:37Z-
dc.date.available2010-09-06T07:39:37Z-
dc.date.issued2006en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2006, v. 24 n. 5, p. 831-836en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78141-
dc.description.abstractBackground: We have previously shown reversal of E-cadherin methylation in gastric mucosa from patients with dyspepsia at week 6 after Helicobacter pylori-eradication therapy. But the long-term methylation status of these patients was unknown. Aim: To investigate the methylation status at E-cadherin at year 3 after H. pylori-eradication therapy. Methods: 35 patients (25 with and 10 without H. pylori eradicated) enrolled in our previous study were recruited into the present study (year 3 analysis). Methylation at E-cadherin was evaluated by methylation-specific polymerase chain reaction method. Results: There was no difference in age and sex distribution in the two groups. Methylation at E-cadherin in patients with H. pylori eradicated at weeks 0, 6 and year 3 were 52%, 20% and 20%, respectively. Concordant methylation status at week 6 and year 3 was 92%. Methylation at E-cadherin in patients without H. pylori at weeks 0, 6 and year 3 were 50%, 60% and 60%, respectively. Concordant methylation status between week 6 and year 3 was 90%. Stability of E-cadherin methylation status was associated with histological changes. No association between E-cadherin methylation status and age was observed. Conclusion: The methylation pattern is stable for a long period, thus suggesting the effect of environment on methylation. © 2006 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAnti-Bacterial Agents - therapeutic useen_HK
dc.subject.meshCadherins - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastric Mucosa - metabolism - pathologyen_HK
dc.subject.meshHelicobacter Infections - drug therapy - metabolism - pathologyen_HK
dc.subject.meshHelicobacter pylorien_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethylationen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPyloric Antrum - metabolism - pathologyen_HK
dc.titleStability of E-cadherin methylation status in gastric mucosa associated with histology changesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=24&issue=5&spage=831&epage=6&date=2006&atitle=Stability+of+E-cadherin+methylation+status+in+gastric+mucosa+associated+with+histology+changes.en_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2036.2006.03032.xen_HK
dc.identifier.pmid16918887-
dc.identifier.scopuseid_2-s2.0-33747346442en_HK
dc.identifier.hkuros122165en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747346442&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue5en_HK
dc.identifier.spage831en_HK
dc.identifier.epage836en_HK
dc.identifier.isiWOS:000239799800013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridHuang, C=15837017600en_HK
dc.identifier.scopusauthoridHui, WM=7103196477en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridRashid, A=7102299914en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.citeulike804794-

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