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Article: Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure

TitleCirculating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure
Authors
Issue Date2000
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Journal Of Respiratory And Critical Care Medicine, 2000, v. 162 n. 6, p. 2166-2171 How to Cite?
AbstractEpidemiological studies have implicated obstructive sleep apnea (OSA) as an independent comorbid factor in cardiovascular and cerebrovascular diseases. The recurrent episodes of occlusion of upper airways during sleep result in pathophysiological changes that may predispose to vascular diseases, and we postulate that nitric oxide may be one of the mediators involved. This study investigates the levels of circulating nitric oxide (NO), measured as serum nitrites and nitrates, in the early morning in OSA subjects compared with control subjects, and the effect of overnight nasal continuous positive airway pressure (nCPAP) in OSA subjects. Thirty men with moderate to severe OSA (age = 41.9 ± 9.0; apnea-hypopnea index, AHI = 48.0 ± 18.1) were compared with 40 healthy men (age = 40.6 ± 5.4; AHI = 1.4 ± 1.2). Serum nitrite/nitrate levels were significantly lower in OSA subjects (OSA = 38.9 ± 22.9 μM, control subjects = 63.1 ± 47.5 μM, p = 0.015). There was significant negative correlation between serum nitrites/nitrates and the following parameters: AHI (r = -0.389, p = 0.001), oxygen desaturation time (r = -0.346, p = 0.004), and systolic blood pressure (BP) (r = -0.335, p = 0.005). Stepwise multiple linear regression with systolic or diastolic BP as the dependent variable identified serum nitrites/nitrates as the only significant correlate. Twenty-two OSA subjects had measurements of serum NO at baseline and after an overnight application nCPAP. There was significant increase in serum NO after nCPAP (baseline = 30.5 ± 14.4 μM, after nCPAP = 81.0 ± 82.1 μM, p = 0.01). This study demonstrates, for the first time, that circulating NO is suppressed in OSA, and this is promptly reversible with the use of nCPAP. The findings offer support for nitric oxide being one of the mediators involved in the acute hemodynamic regulation and long-term vascular remodeling in OSA.
Persistent Identifierhttp://hdl.handle.net/10722/78125
ISSN
2015 Impact Factor: 13.118
2015 SCImago Journal Rankings: 5.832
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorChan, LYen_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorFung, PCWen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-06T07:39:26Z-
dc.date.available2010-09-06T07:39:26Z-
dc.date.issued2000en_HK
dc.identifier.citationAmerican Journal Of Respiratory And Critical Care Medicine, 2000, v. 162 n. 6, p. 2166-2171en_HK
dc.identifier.issn1073-449Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78125-
dc.description.abstractEpidemiological studies have implicated obstructive sleep apnea (OSA) as an independent comorbid factor in cardiovascular and cerebrovascular diseases. The recurrent episodes of occlusion of upper airways during sleep result in pathophysiological changes that may predispose to vascular diseases, and we postulate that nitric oxide may be one of the mediators involved. This study investigates the levels of circulating nitric oxide (NO), measured as serum nitrites and nitrates, in the early morning in OSA subjects compared with control subjects, and the effect of overnight nasal continuous positive airway pressure (nCPAP) in OSA subjects. Thirty men with moderate to severe OSA (age = 41.9 ± 9.0; apnea-hypopnea index, AHI = 48.0 ± 18.1) were compared with 40 healthy men (age = 40.6 ± 5.4; AHI = 1.4 ± 1.2). Serum nitrite/nitrate levels were significantly lower in OSA subjects (OSA = 38.9 ± 22.9 μM, control subjects = 63.1 ± 47.5 μM, p = 0.015). There was significant negative correlation between serum nitrites/nitrates and the following parameters: AHI (r = -0.389, p = 0.001), oxygen desaturation time (r = -0.346, p = 0.004), and systolic blood pressure (BP) (r = -0.335, p = 0.005). Stepwise multiple linear regression with systolic or diastolic BP as the dependent variable identified serum nitrites/nitrates as the only significant correlate. Twenty-two OSA subjects had measurements of serum NO at baseline and after an overnight application nCPAP. There was significant increase in serum NO after nCPAP (baseline = 30.5 ± 14.4 μM, after nCPAP = 81.0 ± 82.1 μM, p = 0.01). This study demonstrates, for the first time, that circulating NO is suppressed in OSA, and this is promptly reversible with the use of nCPAP. The findings offer support for nitric oxide being one of the mediators involved in the acute hemodynamic regulation and long-term vascular remodeling in OSA.en_HK
dc.languageengen_HK
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_HK
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicineen_HK
dc.subject.meshAdulten_HK
dc.subject.meshHumansen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNitric Oxide - blooden_HK
dc.subject.meshNoseen_HK
dc.subject.meshPolysomnographyen_HK
dc.subject.meshPositive-Pressure Respiration - methodsen_HK
dc.subject.meshSleep Apnea, Obstructive - blood - diagnosis - therapyen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.titleCirculating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1073-449X&volume=162&issue=6&spage=2166&epage=2171&date=2000&atitle=Circulating+nitric+oxide+is+suppressed+in+obstructive+sleep+apnea+and+is+reversed+by+nasal+continuous+positive+airway+pressureen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11112132-
dc.identifier.scopuseid_2-s2.0-0034526576en_HK
dc.identifier.hkuros56445en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034526576&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume162en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2166en_HK
dc.identifier.epage2171en_HK
dc.identifier.isiWOS:000165794700034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridChan, LY=17338020800en_HK
dc.identifier.scopusauthoridZheng, L=7403404086en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridFung, PCW=7101613315en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK

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