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Article: A simple tool to identify Asian women at increased risk of osteoporosis

TitleA simple tool to identify Asian women at increased risk of osteoporosis
Authors
Issue Date2001
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 2001, v. 12 n. 8, p. 699-705 How to Cite?
AbstractPatients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available in some communities, because of cost and lack of equipment. Simple questionnaires have been designed to help target high-risk women for BMD measurements, thereby avoiding the cost of measuring women at low risk. However, such tools have previously focused on evaluation of non-Asian women. We collected information about numerous risk factors from postmenopausal Asian women in eight countries in Asia using questionnaires, and evaluated the ability of these risk factors to identify women with osteoporosis as defined by femoral neck BMD T-scores ≤-2.5. Multiple variable regression analysis and item reduction yielded a final tool based on only age and body weight. This risk index had a sensitivity of 91% and specificity of 45%, with an area under the curve of 0.79. Previously published risk indices based on larger numbers of variables performed similarly well in this Asian population. Large differences in risk were identified using our index to create three categories: 61% of the high-risk women had osteoporosis, compared with only 15% and 3% of the intermediate- and low-risk women, respectively. The low-risk group represented 40% of all women, for whom BMD measurements are probably not needed unless important risk factors, such as prior nonviolent fracture or corticosteroid use, are present. An existing population-based sample of postmenopausal Japanese women was used to validate our index. In this sample of Japanese women the sensitivity was 98% and specificity was 29%; the low-risk category, for whom BMD is probably unnecessary, represented 25% of all women. We conclude that our index performed well for classifying the risk of osteoporosis among postmenopausal Asian women and applying it would result in more prudent use of BMD technology.
Persistent Identifierhttp://hdl.handle.net/10722/78121
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKoh, LKHen_HK
dc.contributor.authorBen Sedrine, Wen_HK
dc.contributor.authorTorralba, TPen_HK
dc.contributor.authorKung, Aen_HK
dc.contributor.authorFujiwara, Sen_HK
dc.contributor.authorChan, SPen_HK
dc.contributor.authorHuang, QRen_HK
dc.contributor.authorRajatanavin, Ren_HK
dc.contributor.authorTsai, KSen_HK
dc.contributor.authorPark, HMen_HK
dc.contributor.authorReginster, JYen_HK
dc.date.accessioned2010-09-06T07:39:23Z-
dc.date.available2010-09-06T07:39:23Z-
dc.date.issued2001en_HK
dc.identifier.citationOsteoporosis International, 2001, v. 12 n. 8, p. 699-705en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78121-
dc.description.abstractPatients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available in some communities, because of cost and lack of equipment. Simple questionnaires have been designed to help target high-risk women for BMD measurements, thereby avoiding the cost of measuring women at low risk. However, such tools have previously focused on evaluation of non-Asian women. We collected information about numerous risk factors from postmenopausal Asian women in eight countries in Asia using questionnaires, and evaluated the ability of these risk factors to identify women with osteoporosis as defined by femoral neck BMD T-scores ≤-2.5. Multiple variable regression analysis and item reduction yielded a final tool based on only age and body weight. This risk index had a sensitivity of 91% and specificity of 45%, with an area under the curve of 0.79. Previously published risk indices based on larger numbers of variables performed similarly well in this Asian population. Large differences in risk were identified using our index to create three categories: 61% of the high-risk women had osteoporosis, compared with only 15% and 3% of the intermediate- and low-risk women, respectively. The low-risk group represented 40% of all women, for whom BMD measurements are probably not needed unless important risk factors, such as prior nonviolent fracture or corticosteroid use, are present. An existing population-based sample of postmenopausal Japanese women was used to validate our index. In this sample of Japanese women the sensitivity was 98% and specificity was 29%; the low-risk category, for whom BMD is probably unnecessary, represented 25% of all women. We conclude that our index performed well for classifying the risk of osteoporosis among postmenopausal Asian women and applying it would result in more prudent use of BMD technology.en_HK
dc.languageengen_HK
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.subject.meshAbsorptiometry, Photonen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshArea Under Curveen_HK
dc.subject.meshAsia - ethnologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshOsteoporosis, Postmenopausal - diagnosis - ethnologyen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.titleA simple tool to identify Asian women at increased risk of osteoporosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0937-941X&volume=12&spage=699&epage=705&date=2001&atitle=A+simple+tool+to+identify+Asian+women+at+increased+risk+of+osteoporosisen_HK
dc.identifier.emailKung, A:awckung@hku.hken_HK
dc.identifier.authorityKung, A=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s001980170070en_HK
dc.identifier.pmid11580084-
dc.identifier.scopuseid_2-s2.0-0034821007en_HK
dc.identifier.hkuros66568en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034821007&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue8en_HK
dc.identifier.spage699en_HK
dc.identifier.epage705en_HK
dc.identifier.isiWOS:000171206900011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKoh, LKH=7004786475en_HK
dc.identifier.scopusauthoridBen Sedrine, W=8760831000en_HK
dc.identifier.scopusauthoridTorralba, TP=6602685307en_HK
dc.identifier.scopusauthoridKung, A=7102322339en_HK
dc.identifier.scopusauthoridFujiwara, S=7401827353en_HK
dc.identifier.scopusauthoridChan, SP=7404255462en_HK
dc.identifier.scopusauthoridHuang, QR=25951408700en_HK
dc.identifier.scopusauthoridRajatanavin, R=7006677064en_HK
dc.identifier.scopusauthoridTsai, KS=7201566015en_HK
dc.identifier.scopusauthoridPark, HM=13005826700en_HK
dc.identifier.scopusauthoridReginster, JY=35378176800en_HK

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