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Article: M235T polymorphism of the angiotensinogen gene and hypertension in Chinese

TitleM235T polymorphism of the angiotensinogen gene and hypertension in Chinese
Authors
KeywordsAngiotensinogen
Gene
Hypertension
Polymorphism
Issue Date1998
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 1998, v. 16 n. 8, p. 1137-1140 How to Cite?
AbstractObjectives: To compare the distributions of the genotypes and alleles of the M235T polymorphism of the angiotensinogen gene for hypertensive patients and normotensive controls. Design: A study of association of genetic polymorphisms. Setting: An outpatient clinic run by a university department handling referrals from primary care. Patients: Two hundred and four subjects, 103 normal controls and 101 patients with newly diagnosed or documented hypertension. Method: Genomic DNA was extracted from peripheral blood leucocytes, amplified by polymerase chain reaction and digested with the restriction enzyme Tth 111 I. Methionine (M) and threonine (T) alleles were identified after electrophoresis. Main outcome measures: Prevalences of angiotensinogen genotypes and alleles for hypertensive patients and controls. Results: MM, TM and TT genotypes occurred in 3, 24 and 73% of controls and 1, 22 and 77% of hypertensive patients, respectively. The prevalences of the M and T alleles were 0.15 and 0.85 among controls and 0.12 and 0.88 among hypertensive patients. The prevalences of the angiotensinogen genotypes and alleles for controls and hypertensive patients did not differ significantly. Conclusions: Our findings differed from previous reports and suggested that this polymorphism is not associated with hypertension in this population.
Persistent Identifierhttp://hdl.handle.net/10722/78083
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorShiu, Sen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorKumana, CRen_HK
dc.date.accessioned2010-09-06T07:38:59Z-
dc.date.available2010-09-06T07:38:59Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Hypertension, 1998, v. 16 n. 8, p. 1137-1140en_HK
dc.identifier.issn0263-6352en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78083-
dc.description.abstractObjectives: To compare the distributions of the genotypes and alleles of the M235T polymorphism of the angiotensinogen gene for hypertensive patients and normotensive controls. Design: A study of association of genetic polymorphisms. Setting: An outpatient clinic run by a university department handling referrals from primary care. Patients: Two hundred and four subjects, 103 normal controls and 101 patients with newly diagnosed or documented hypertension. Method: Genomic DNA was extracted from peripheral blood leucocytes, amplified by polymerase chain reaction and digested with the restriction enzyme Tth 111 I. Methionine (M) and threonine (T) alleles were identified after electrophoresis. Main outcome measures: Prevalences of angiotensinogen genotypes and alleles for hypertensive patients and controls. Results: MM, TM and TT genotypes occurred in 3, 24 and 73% of controls and 1, 22 and 77% of hypertensive patients, respectively. The prevalences of the M and T alleles were 0.15 and 0.85 among controls and 0.12 and 0.88 among hypertensive patients. The prevalences of the angiotensinogen genotypes and alleles for controls and hypertensive patients did not differ significantly. Conclusions: Our findings differed from previous reports and suggested that this polymorphism is not associated with hypertension in this population.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_HK
dc.relation.ispartofJournal of Hypertensionen_HK
dc.rightsJournal of Hypertension. Copyright © Lippincott Williams & Wilkins, Ltd.en_HK
dc.subjectAngiotensinogenen_HK
dc.subjectGeneen_HK
dc.subjectHypertensionen_HK
dc.subjectPolymorphismen_HK
dc.titleM235T polymorphism of the angiotensinogen gene and hypertension in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0263-6352&volume=16&issue=8&spage=1137&epage=1140&date=1998&atitle=M235T+polymorphism+of+the+angiotensinogen+gene+and+hypertension+in+Chineseen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00004872-199816080-00009en_HK
dc.identifier.pmid9794717-
dc.identifier.scopuseid_2-s2.0-0031824430en_HK
dc.identifier.hkuros38244en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031824430&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1137en_HK
dc.identifier.epage1140en_HK
dc.identifier.isiWOS:000075026800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridShiu, S=7005550652en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK

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