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Article: Profile of lupus autoantibodies found in Asia

TitleProfile of lupus autoantibodies found in Asia
Authors
KeywordsAntiphospholipid antibody
Autoantibodies
Epidemiology
Prevalence
Race
Issue Date2006
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APL
Citation
Aplar Journal Of Rheumatology, 2006, v. 9 n. 4, p. 331-335 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is characterized by the presence of serum hypergammaglobulinaemia and a vast variety of autoantibodies. As SLE is a multifactorial disease, different genetic makeup in different ethnic groups is likely to contribute to variations on disease prevalence, clinical features and autoantibody profiles. In this article, the prevalence of autoantibody profiles and their clinical associations in SLE patients in different Asian countries were reviewed. Anti-extractable nuclear antibodies including anti-Ro and anti-Sm antibodies were found to be more frequent in Eastern patients than Caucasians. On the other hand, the prevalence of antiphospholipid antibodies was lower in Asians. The clinical associations of different autoantibodies are in general similar to those reported in Caucasian cohorts but with some variations in different Asian countries. This may be affected by the method of measurement of these serum autoantibodies, standardization of immunoassays, sample size of the studies and the method of statistical analysis. Immunogenetic studies into some autoantibodies including anti-Ro/SSA and beta2 glycoprotein I-dependent anticardiolipin antibodies in Asian lupus patients revealed association with HLA Class II alleles. © 2006 Asia Pacific League of Associations for Rheumatology.
Persistent Identifierhttp://hdl.handle.net/10722/78054
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.date.accessioned2010-09-06T07:38:39Z-
dc.date.available2010-09-06T07:38:39Z-
dc.date.issued2006en_HK
dc.identifier.citationAplar Journal Of Rheumatology, 2006, v. 9 n. 4, p. 331-335en_HK
dc.identifier.issn0219-0494en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78054-
dc.description.abstractSystemic lupus erythematosus (SLE) is characterized by the presence of serum hypergammaglobulinaemia and a vast variety of autoantibodies. As SLE is a multifactorial disease, different genetic makeup in different ethnic groups is likely to contribute to variations on disease prevalence, clinical features and autoantibody profiles. In this article, the prevalence of autoantibody profiles and their clinical associations in SLE patients in different Asian countries were reviewed. Anti-extractable nuclear antibodies including anti-Ro and anti-Sm antibodies were found to be more frequent in Eastern patients than Caucasians. On the other hand, the prevalence of antiphospholipid antibodies was lower in Asians. The clinical associations of different autoantibodies are in general similar to those reported in Caucasian cohorts but with some variations in different Asian countries. This may be affected by the method of measurement of these serum autoantibodies, standardization of immunoassays, sample size of the studies and the method of statistical analysis. Immunogenetic studies into some autoantibodies including anti-Ro/SSA and beta2 glycoprotein I-dependent anticardiolipin antibodies in Asian lupus patients revealed association with HLA Class II alleles. © 2006 Asia Pacific League of Associations for Rheumatology.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APLen_HK
dc.relation.ispartofAPLAR Journal of Rheumatologyen_HK
dc.subjectAntiphospholipid antibodyen_HK
dc.subjectAutoantibodiesen_HK
dc.subjectEpidemiologyen_HK
dc.subjectPrevalenceen_HK
dc.subjectRaceen_HK
dc.titleProfile of lupus autoantibodies found in Asiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0219-0494&volume=9&issue=4&spage=331&epage=335&date=2006&atitle=Profile+of+lupus+autoantibodies+found+in+Asiaen_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1479-8077.2006.00227.xen_HK
dc.identifier.scopuseid_2-s2.0-33750991576en_HK
dc.identifier.hkuros134334en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750991576&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue4en_HK
dc.identifier.spage331en_HK
dc.identifier.epage335en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK

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