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Article: Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias

TitleEpigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias
Authors
Issue Date2004
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2004, v. 83 n. 8, p. 527-532 How to Cite?
AbstractSOCS1 and SHP1 are negative regulators of the Jak/STAT signalling pathway that is implicated in leukaemogenesis. We studied if aberrant methylation of SOCS1 and SHP1 might be involved in the pathogenesis and prognostication of acute leukaemias by methylation-specific polymerase chain reaction (MSP). At diagnosis, methylation of SHP1 occurred more frequently in acute myeloid leukaemia (AML) (n=26, 52%) than acute lymphoblastic leukaemia (ALL) (n=6, 24%) (p=0.02). Methylation of SOCS1 was absent in both AML and ALL patients. SHP1 methylation was not associated with specific clinicopathologic features and had no prognostic impact on AML patients. Frequent methylation of SHP1, but not SOCS1, may be important in the pathogenesis, but not prognosis, of acute leukaemias. © Springer-Verlag 2004.
Persistent Identifierhttp://hdl.handle.net/10722/78051
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChim, CSen_HK
dc.contributor.authorWong, ASYen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:38:37Z-
dc.date.available2010-09-06T07:38:37Z-
dc.date.issued2004en_HK
dc.identifier.citationAnnals Of Hematology, 2004, v. 83 n. 8, p. 527-532en_HK
dc.identifier.issn0939-5555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78051-
dc.description.abstractSOCS1 and SHP1 are negative regulators of the Jak/STAT signalling pathway that is implicated in leukaemogenesis. We studied if aberrant methylation of SOCS1 and SHP1 might be involved in the pathogenesis and prognostication of acute leukaemias by methylation-specific polymerase chain reaction (MSP). At diagnosis, methylation of SHP1 occurred more frequently in acute myeloid leukaemia (AML) (n=26, 52%) than acute lymphoblastic leukaemia (ALL) (n=6, 24%) (p=0.02). Methylation of SOCS1 was absent in both AML and ALL patients. SHP1 methylation was not associated with specific clinicopathologic features and had no prognostic impact on AML patients. Frequent methylation of SHP1, but not SOCS1, may be important in the pathogenesis, but not prognosis, of acute leukaemias. © Springer-Verlag 2004.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_HK
dc.relation.ispartofAnnals of Hematologyen_HK
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarrier Proteins - metabolismen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshDNA Methylationen_HK
dc.subject.meshDNA-Binding Proteins - metabolismen_HK
dc.subject.meshEpigenesis, Geneticen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntracellular Signaling Peptides and Proteinsen_HK
dc.subject.meshJanus Kinase 1en_HK
dc.subject.meshLeukemia - etiology - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethylationen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProtein Tyrosine Phosphatase, Non-Receptor Type 6en_HK
dc.subject.meshProtein Tyrosine Phosphatases - metabolismen_HK
dc.subject.meshProtein-Tyrosine Kinases - metabolismen_HK
dc.subject.meshRepressor Proteins - metabolismen_HK
dc.subject.meshSTAT1 Transcription Factoren_HK
dc.subject.meshSignal Transduction - geneticsen_HK
dc.subject.meshSuppressor of Cytokine Signaling Proteinsen_HK
dc.subject.meshTrans-Activators - metabolismen_HK
dc.titleEpigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemiasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0939-5555&volume=83&issue=8&spage=527&epage=32&date=2004&atitle=Epigenetic+dysregulation+of+the+Jak/STAT+pathway+by+frequent+aberrant+methylation+of+SHP1+but+not+SOCS1+in+acute+leukaemiasen_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid14762685-
dc.identifier.scopuseid_2-s2.0-4344623279en_HK
dc.identifier.hkuros88705en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344623279&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue8en_HK
dc.identifier.spage527en_HK
dc.identifier.epage532en_HK
dc.identifier.isiWOS:000222691700007-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridWong, ASY=7403144356en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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