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Article: The interleukin-10 - 1082 G/A polymorphism: Allele frequency in different populations and functional significance

TitleThe interleukin-10 - 1082 G/A polymorphism: Allele frequency in different populations and functional significance
Authors
KeywordsAllele frequency
Cytokine
Interleukin-10
Polymorphism
Transcription
Transcription factor
Issue Date2002
PublisherBirkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm
Citation
Cellular And Molecular Life Sciences, 2002, v. 59 n. 3, p. 560-569 How to Cite?
AbstractGenotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position - 1082 has been linked to high/low IL-10 producer status. We directly tested the functional significance of this polymorphism using DNA-binding assays and reporter gene assays, examined allele frequencies in two geographically distinct populations and assessed intra- and inter-individual variation in IL-10 production in vitro according to genotype. Functional analyses showed that the - 1082 region contains a putative ETS-like transcription factor-binding site, and nuclear factors from a monocyte cell line bind to this region. Transient transfection studies in an Epstein-Barr virus-transformed B cell line indicated that the - 1082 A allele confers a two fold increase in transcriptional activity of the IL-10 promoter compared to the G allele. There was marked inter-individual variation in IL-10 production by peripheral blood mononuclear cells in vitro, with no consistent effect of genotype.
Persistent Identifierhttp://hdl.handle.net/10722/78046
ISSN
2015 Impact Factor: 5.694
2015 SCImago Journal Rankings: 3.388
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRees, LENen_HK
dc.contributor.authorWood, NAPen_HK
dc.contributor.authorGillespie, KMen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorGaston, Ken_HK
dc.contributor.authorMathieson, PWen_HK
dc.date.accessioned2010-09-06T07:38:34Z-
dc.date.available2010-09-06T07:38:34Z-
dc.date.issued2002en_HK
dc.identifier.citationCellular And Molecular Life Sciences, 2002, v. 59 n. 3, p. 560-569en_HK
dc.identifier.issn1420-682Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78046-
dc.description.abstractGenotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position - 1082 has been linked to high/low IL-10 producer status. We directly tested the functional significance of this polymorphism using DNA-binding assays and reporter gene assays, examined allele frequencies in two geographically distinct populations and assessed intra- and inter-individual variation in IL-10 production in vitro according to genotype. Functional analyses showed that the - 1082 region contains a putative ETS-like transcription factor-binding site, and nuclear factors from a monocyte cell line bind to this region. Transient transfection studies in an Epstein-Barr virus-transformed B cell line indicated that the - 1082 A allele confers a two fold increase in transcriptional activity of the IL-10 promoter compared to the G allele. There was marked inter-individual variation in IL-10 production by peripheral blood mononuclear cells in vitro, with no consistent effect of genotype.en_HK
dc.languageengen_HK
dc.publisherBirkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htmen_HK
dc.relation.ispartofCellular and Molecular Life Sciencesen_HK
dc.subjectAllele frequencyen_HK
dc.subjectCytokineen_HK
dc.subjectInterleukin-10en_HK
dc.subjectPolymorphismen_HK
dc.subjectTranscriptionen_HK
dc.subjectTranscription factoren_HK
dc.titleThe interleukin-10 - 1082 G/A polymorphism: Allele frequency in different populations and functional significanceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1672-7681&volume=59&issue=3&spage=560&epage=569&date=2002&atitle=The+interleukin-10-1082+G/A+polymorphism:+allele+frequency+in+different+populations+and+functional+significanceen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00018-002-8448-0en_HK
dc.identifier.pmid11964134-
dc.identifier.scopuseid_2-s2.0-0036208781en_HK
dc.identifier.hkuros69580en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036208781&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue3en_HK
dc.identifier.spage560en_HK
dc.identifier.epage569en_HK
dc.identifier.isiWOS:000174840500019-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridRees, LEN=35969772200en_HK
dc.identifier.scopusauthoridWood, NAP=7202962395en_HK
dc.identifier.scopusauthoridGillespie, KM=35373829500en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridGaston, K=36048139700en_HK
dc.identifier.scopusauthoridMathieson, PW=7005677484en_HK

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