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Article: New measure of health-related quality of life for patients with oropharyngeal mucositis: Development and preliminary psychometric evaluation

TitleNew measure of health-related quality of life for patients with oropharyngeal mucositis: Development and preliminary psychometric evaluation
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2007, v. 109 n. 12, p. 2590-2599 How to Cite?
AbstractBACKGROUND. Oropharyngeal mucositis (OM) causes profound impairment of patients' health-related quality of life (HQoL). The aim of the article is to describe the development and preliminary validation of an HQoL instrument, OMQoL, specifically for patients with OM. METHODS. First, a qualitative phase was conducted to generate items (n = 23). Face validity was assessed by focus group interviews (n = 13). Expert content review (n = 7) was used to ensure content validity. The second step was a quantitative validation phase comprised a multicenter study (n = 210) to help identify subscales of the instrument addressing different dimensions of OM and to measure reliability. RESULTS. The qualitative interview generated 171 items. Using focus group discussion and expert content review, items were reduced to 41 items. Factor and scaling analyses of these 41 items resulted in 4 subscales, contributed by 31 items, depicting problems with symptoms, diet, social function, and swallowing. The floor effect was modest. The factorial structure was satisfactory with loading >0.40 on each subscale for all items. All corrected item-total corrections were higher than 0.40 (r = 0.457-0.874). The internal consistency reliability of each subscale was high, with Cronbach alpha coefficients ranging from 0.906 to 0.934. The test-retest reliability of the individual items using weighted kappa was good (kappa values 0.610-0.895). The intraclass correlation results for the subscale totals were all in excess of 0.70 (0.864-0.934). CONCLUSIONS. An initial psychometric analysis of the OMQoL was encouraging. The OMQoL could provide a valuable tool for the assessment of HQoL of patients with OM. © 2007 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/78037
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, KKFen_HK
dc.contributor.authorLeung, SFen_HK
dc.contributor.authorThompson, DRen_HK
dc.contributor.authorTai, JWMen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorKan, ASTen_HK
dc.contributor.authorYing, FWOen_HK
dc.contributor.authorYeung, RMWen_HK
dc.date.accessioned2010-09-06T07:38:29Z-
dc.date.available2010-09-06T07:38:29Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer, 2007, v. 109 n. 12, p. 2590-2599en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78037-
dc.description.abstractBACKGROUND. Oropharyngeal mucositis (OM) causes profound impairment of patients' health-related quality of life (HQoL). The aim of the article is to describe the development and preliminary validation of an HQoL instrument, OMQoL, specifically for patients with OM. METHODS. First, a qualitative phase was conducted to generate items (n = 23). Face validity was assessed by focus group interviews (n = 13). Expert content review (n = 7) was used to ensure content validity. The second step was a quantitative validation phase comprised a multicenter study (n = 210) to help identify subscales of the instrument addressing different dimensions of OM and to measure reliability. RESULTS. The qualitative interview generated 171 items. Using focus group discussion and expert content review, items were reduced to 41 items. Factor and scaling analyses of these 41 items resulted in 4 subscales, contributed by 31 items, depicting problems with symptoms, diet, social function, and swallowing. The floor effect was modest. The factorial structure was satisfactory with loading >0.40 on each subscale for all items. All corrected item-total corrections were higher than 0.40 (r = 0.457-0.874). The internal consistency reliability of each subscale was high, with Cronbach alpha coefficients ranging from 0.906 to 0.934. The test-retest reliability of the individual items using weighted kappa was good (kappa values 0.610-0.895). The intraclass correlation results for the subscale totals were all in excess of 0.70 (0.864-0.934). CONCLUSIONS. An initial psychometric analysis of the OMQoL was encouraging. The OMQoL could provide a valuable tool for the assessment of HQoL of patients with OM. © 2007 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFocus Groupsen_HK
dc.subject.meshHealth Status Indicatorsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterviews as Topicen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMucositis - diagnosis - etiologyen_HK
dc.subject.meshNeoplasms - complications - drug therapyen_HK
dc.subject.meshOropharynx - drug effects - pathologyen_HK
dc.subject.meshOutcome Assessment (Health Care)en_HK
dc.subject.meshPsychometricsen_HK
dc.subject.meshQuality of Lifeen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshSocial Behavioren_HK
dc.titleNew measure of health-related quality of life for patients with oropharyngeal mucositis: Development and preliminary psychometric evaluationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=109&spage=2590&epage=2599&date=2007&atitle=New+measure+of+health-related+quality+of+life+for+patients+with+oropharyngeal+mucositis:+development+and+preliminary+psychometric+evaluationen_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.22730en_HK
dc.identifier.pmid17492684-
dc.identifier.scopuseid_2-s2.0-34250203600en_HK
dc.identifier.hkuros136886en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250203600&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume109en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2590en_HK
dc.identifier.epage2599en_HK
dc.identifier.isiWOS:000247113500026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, KKF=27172284100en_HK
dc.identifier.scopusauthoridLeung, SF=22955953000en_HK
dc.identifier.scopusauthoridThompson, DR=7404935331en_HK
dc.identifier.scopusauthoridTai, JWM=7101993154en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridKan, AST=16480422600en_HK
dc.identifier.scopusauthoridYing, FWO=16481689700en_HK
dc.identifier.scopusauthoridYeung, RMW=7102833329en_HK

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