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Article: Attenuation of Left Ventricular Adverse Remodeling With Epicardial Patching After Myocardial Infarction

TitleAttenuation of Left Ventricular Adverse Remodeling With Epicardial Patching After Myocardial Infarction
Authors
KeywordsEpicardial patch
myocardial infarction
ventricular remodeling
Issue Date2010
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cardfail
Citation
Journal Of Cardiac Failure, 2010, v. 16 n. 7, p. 590-598 How to Cite?
AbstractBackground: Previous studies suggested that epicardial patch applied to the infarcted site after acute myocardial infarction (MI) can alleviate left ventricular (LV) remodeling and improve cardiac performance; however, the effects of regional epicardial patch on chronic phase of LV remodeling remain unclear. Methods and Results: We studied 20 pigs with MI induced by distal embolization and impaired LV ejection fraction (LVEF <45%) as detected by gadolinium-enhanced cardiac magnetic resonance imaging (MRI). Eight weeks post-MI, all animal underwent open chest procedure for sham surgery (control, n = 12) or patch implantation over the infarcted lateral LV wall (patch group, n = 12). In the patch group, +dP/dt increased and LV end-diastolic pressure decreased at 20 weeks compared with immediately post-MI and at 8 weeks (P < .05), but not in the control group (P > .05). As determined by cardiac MRI, LV end-diastolic and end-systolic volumes increased at 20 weeks compared with 8 weeks in both groups (P < .05). However, the increase in LV end-diastolic volume (+14.1 ± 1.8% vs. +6.6 ± 2.1%, P = .015) and LV end-systolic volume (+12.1 ± 2.4% vs. -4.7 ± 3.7%, P = .0015) were significantly greater in the control group compared with the patch group. Furthermore, the percentage increase in LVEF (+17.3 ± 4.9% vs. +4.1 ± 3.9%, P = .048) from 8 to 20 weeks was significantly greater in the patch group compared with the control group. Histological examination showed that LV wall thickness at the infarct region and adjacent peri-infarct regions were significantly greater in the patch group compared with the control group (P < .05). Conclusion: Regional application of a simple, passive synthetic epicardial patch increased LV wall thickness at the infarct region, attenuated LV dilation, and improved LVEF and +dP/dt in a large animal model of MI. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78024
ISSN
2015 Impact Factor: 3.259
2015 SCImago Journal Rankings: 1.492
ISI Accession Number ID
Funding AgencyGrant Number
Cardiac Rhythm Management Division, St. Jude Medical, USA
Research Grants Council of Hong KongHKU 7594/05M
HKU 7633/06M
HKU 7769/08M
Funding Information:

Supported in part by Cardiac Rhythm Management Division, St. Jude Medical, USA, and Research Grants Council of Hong Kong, General Research Fund (No. HKU 7594/05M; HKU 7633/06M; HKU 7769/08M)

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLiao, SYen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorChan, WSen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorWu, Yen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorLi, RAen_HK
dc.contributor.authorBenser, MEen_HK
dc.contributor.authorRosenberg, SPen_HK
dc.contributor.authorPark, Een_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T07:38:19Z-
dc.date.available2010-09-06T07:38:19Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Cardiac Failure, 2010, v. 16 n. 7, p. 590-598en_HK
dc.identifier.issn1071-9164en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78024-
dc.description.abstractBackground: Previous studies suggested that epicardial patch applied to the infarcted site after acute myocardial infarction (MI) can alleviate left ventricular (LV) remodeling and improve cardiac performance; however, the effects of regional epicardial patch on chronic phase of LV remodeling remain unclear. Methods and Results: We studied 20 pigs with MI induced by distal embolization and impaired LV ejection fraction (LVEF <45%) as detected by gadolinium-enhanced cardiac magnetic resonance imaging (MRI). Eight weeks post-MI, all animal underwent open chest procedure for sham surgery (control, n = 12) or patch implantation over the infarcted lateral LV wall (patch group, n = 12). In the patch group, +dP/dt increased and LV end-diastolic pressure decreased at 20 weeks compared with immediately post-MI and at 8 weeks (P < .05), but not in the control group (P > .05). As determined by cardiac MRI, LV end-diastolic and end-systolic volumes increased at 20 weeks compared with 8 weeks in both groups (P < .05). However, the increase in LV end-diastolic volume (+14.1 ± 1.8% vs. +6.6 ± 2.1%, P = .015) and LV end-systolic volume (+12.1 ± 2.4% vs. -4.7 ± 3.7%, P = .0015) were significantly greater in the control group compared with the patch group. Furthermore, the percentage increase in LVEF (+17.3 ± 4.9% vs. +4.1 ± 3.9%, P = .048) from 8 to 20 weeks was significantly greater in the patch group compared with the control group. Histological examination showed that LV wall thickness at the infarct region and adjacent peri-infarct regions were significantly greater in the patch group compared with the control group (P < .05). Conclusion: Regional application of a simple, passive synthetic epicardial patch increased LV wall thickness at the infarct region, attenuated LV dilation, and improved LVEF and +dP/dt in a large animal model of MI. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cardfailen_HK
dc.relation.ispartofJournal of Cardiac Failureen_HK
dc.subjectEpicardial patchen_HK
dc.subjectmyocardial infarctionen_HK
dc.subjectventricular remodelingen_HK
dc.subject.meshMyocardial Infarction - pathology - physiopathology - surgery-
dc.subject.meshPericardium - pathology - physiopathology-
dc.subject.meshProsthesis Implantation - methods-
dc.subject.meshVentricular Dysfunction, Left - physiopathology - surgery-
dc.subject.meshVentricular Remodeling - physiology-
dc.titleAttenuation of Left Ventricular Adverse Remodeling With Epicardial Patching After Myocardial Infarctionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1071-9164&volume=16&issue=7&spage=590&epage=598&date=2010&atitle=Attenuation+of+left+ventricular+adverse+remodeling+with+epicardial+patching+after+myocardial+infarctionen_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.emailLi, RA:ronaldli@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityLi, RA=rp01352en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cardfail.2010.02.007en_HK
dc.identifier.pmid20610235-
dc.identifier.scopuseid_2-s2.0-77953809259en_HK
dc.identifier.hkuros169693en_HK
dc.identifier.hkuros222569-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953809259&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue7en_HK
dc.identifier.spage590en_HK
dc.identifier.epage598en_HK
dc.identifier.isiWOS:000279969100007-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectEmbryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling-
dc.relation.projectGenetic enrichment of cardiac derivatives from human embryonic stem cells and their bioengineering for cell-based heart therapies-
dc.identifier.scopusauthoridLiao, SY=22433820700en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLiu, Y=36071722500en_HK
dc.identifier.scopusauthoridZhang, Y=35785466900en_HK
dc.identifier.scopusauthoridChan, WS=13104241000en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridWu, Y=8940205500en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridLi, RA=7404724466en_HK
dc.identifier.scopusauthoridBenser, ME=6602158430en_HK
dc.identifier.scopusauthoridRosenberg, SP=37024693200en_HK
dc.identifier.scopusauthoridPark, E=7402224798en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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