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Conference Paper: Biology of hepatocellular carcinoma

TitleBiology of hepatocellular carcinoma
Authors
KeywordsAngiogenesis
Biological factors
Biomarkers
Gene expression
Hepatocellular
Molecular
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2008, v. 15 n. 4, p. 962-971 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a common cancer in the world due to high prevalence of hepatitis B or C virus infection. Research in recent years has uncovered important molecular pathways involved in development and progression of HCC. Several genetic aberrations and molecular mechanisms responsible for initiation of hepatocarcinogenesis have been identified. Novel biomarkers for HCC are being developed for better detection and prognostication. Alpha-fetoprotein, the conventional marker of HCC, has limited sensitivity and specificity. Serum levels of isoforms of AFP based on differential lectin binding of the glycan moiety appear to be more sensitive and specific than total AFP level in early detection of HCC. The clinical usefulness of other HCC biomarkers such as des-γ-carboxy prothrombin and glypican-3 are under investigation. HCC is an aggressive tumor with early vascular invasion and metastasis. Studies over the past two decades have elucidated the clinical predictors of outcome, leading to several staging systems for HCC based on clinical parameters. However, the predictive accuracy of clinical staging systems is limited. Recent studies suggested that biological factors may provide additional prognostic information. In particular, gene expression profiling appears to be a promising approach. Study of tumor angiogenesis in HCC reveals that the expression of angiogenic factors such as vascular endothelial growth factor and angiopoietins may also predict prognosis. The elucidation of tumor biology of HCC is of particular importance in the current era of rapid development of anti-cancer molecular targeting agents, which provide hope for an effective systemic therapy for HCC. © 2007 Society of Surgical Oncology.
Persistent Identifierhttp://hdl.handle.net/10722/78014
ISSN
2014 Impact Factor: 3.930
2014 SCImago Journal Rankings: 1.812
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, RWCen_HK
dc.contributor.authorJoh, JWen_HK
dc.contributor.authorJohnson, PJen_HK
dc.contributor.authorMonden, Men_HK
dc.contributor.authorPawlik, TMen_HK
dc.contributor.authorPoon, RTPen_HK
dc.date.accessioned2010-09-06T07:38:13Z-
dc.date.available2010-09-06T07:38:13Z-
dc.date.issued2008en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2008, v. 15 n. 4, p. 962-971en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78014-
dc.description.abstractHepatocellular carcinoma (HCC) is a common cancer in the world due to high prevalence of hepatitis B or C virus infection. Research in recent years has uncovered important molecular pathways involved in development and progression of HCC. Several genetic aberrations and molecular mechanisms responsible for initiation of hepatocarcinogenesis have been identified. Novel biomarkers for HCC are being developed for better detection and prognostication. Alpha-fetoprotein, the conventional marker of HCC, has limited sensitivity and specificity. Serum levels of isoforms of AFP based on differential lectin binding of the glycan moiety appear to be more sensitive and specific than total AFP level in early detection of HCC. The clinical usefulness of other HCC biomarkers such as des-γ-carboxy prothrombin and glypican-3 are under investigation. HCC is an aggressive tumor with early vascular invasion and metastasis. Studies over the past two decades have elucidated the clinical predictors of outcome, leading to several staging systems for HCC based on clinical parameters. However, the predictive accuracy of clinical staging systems is limited. Recent studies suggested that biological factors may provide additional prognostic information. In particular, gene expression profiling appears to be a promising approach. Study of tumor angiogenesis in HCC reveals that the expression of angiogenic factors such as vascular endothelial growth factor and angiopoietins may also predict prognosis. The elucidation of tumor biology of HCC is of particular importance in the current era of rapid development of anti-cancer molecular targeting agents, which provide hope for an effective systemic therapy for HCC. © 2007 Society of Surgical Oncology.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.subjectAngiogenesisen_HK
dc.subjectBiological factorsen_HK
dc.subjectBiomarkersen_HK
dc.subjectGene expressionen_HK
dc.subjectHepatocellularen_HK
dc.subjectMolecularen_HK
dc.titleBiology of hepatocellular carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1068-9265&volume=15&issue=4&spage=962&epage=971&date=2008&atitle=Biology+of+hepatocellular+carcinomaen_HK
dc.identifier.emailPang, RWC: robertap@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.authorityPang, RWC=rp00274en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-007-9730-zen_HK
dc.identifier.pmid18236113en_HK
dc.identifier.scopuseid_2-s2.0-40549100994en_HK
dc.identifier.hkuros150869en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40549100994&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage962en_HK
dc.identifier.epage971en_HK
dc.identifier.isiWOS:000253896000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPang, RWC=7004376659en_HK
dc.identifier.scopusauthoridJoh, JW=7005275030en_HK
dc.identifier.scopusauthoridJohnson, PJ=7405661637en_HK
dc.identifier.scopusauthoridMonden, M=35373029900en_HK
dc.identifier.scopusauthoridPawlik, TM=7006249269en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.citeulike3978074-

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