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Article: Bicyclol: A useful agent for chemoprevention of hepatocellular carcinoma?

TitleBicyclol: A useful agent for chemoprevention of hepatocellular carcinoma?
Authors
KeywordsBicyclol
Chemoprevention
Hepatocarcinogenesis
Hepatocellular carcinoma
Issue Date2006
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cbt/index.php
Citation
Cancer Biology And Therapy, 2006, v. 5 n. 12, p. 1674-1676 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a major health problem worldwide, involving more than 620,000 new cases yearly, with chronic HBV and HCV infection being the most common causes. Because most patients are diagnosed in an advanced stage which is usually not amenable to curative therapy, prevention should be the main focus for reducing the HCC incidence and its related morbidity and mortality. Strategies of HCC prevention can focus on each single risk factor, with antiviral therapy against chronic hepatitis B and hepatitis C as well as suppression of the progression of common liver diseases being the most important and effective measures. Bicyclol, a drug that can improve liver function and inhibit HBV replication, may be a useful agent for the chemopreventive of HCC, as indicated by a recent study by Zhu et al. Bicyclol can act on the initiation and promotion stages of hepatocarcinogenesis by preventing malignant transformation of hepatic cells. It may also enhance the liver's capacity of detoxification and inhibit DNA mutations. More clinical studies are needed to further demonstrate the efficacy and molecular mechanisms of this agent on HCC chemoprevention. ©2006 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/77952
ISSN
2015 Impact Factor: 2.921
2015 SCImago Journal Rankings: 1.297
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Qen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorQiao, Len_HK
dc.date.accessioned2010-09-06T07:37:33Z-
dc.date.available2010-09-06T07:37:33Z-
dc.date.issued2006en_HK
dc.identifier.citationCancer Biology And Therapy, 2006, v. 5 n. 12, p. 1674-1676en_HK
dc.identifier.issn1538-4047en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77952-
dc.description.abstractHepatocellular carcinoma (HCC) is a major health problem worldwide, involving more than 620,000 new cases yearly, with chronic HBV and HCV infection being the most common causes. Because most patients are diagnosed in an advanced stage which is usually not amenable to curative therapy, prevention should be the main focus for reducing the HCC incidence and its related morbidity and mortality. Strategies of HCC prevention can focus on each single risk factor, with antiviral therapy against chronic hepatitis B and hepatitis C as well as suppression of the progression of common liver diseases being the most important and effective measures. Bicyclol, a drug that can improve liver function and inhibit HBV replication, may be a useful agent for the chemopreventive of HCC, as indicated by a recent study by Zhu et al. Bicyclol can act on the initiation and promotion stages of hepatocarcinogenesis by preventing malignant transformation of hepatic cells. It may also enhance the liver's capacity of detoxification and inhibit DNA mutations. More clinical studies are needed to further demonstrate the efficacy and molecular mechanisms of this agent on HCC chemoprevention. ©2006 Landes Bioscience.en_HK
dc.languageengen_HK
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cbt/index.phpen_HK
dc.relation.ispartofCancer Biology and Therapyen_HK
dc.subjectBicyclolen_HK
dc.subjectChemopreventionen_HK
dc.subjectHepatocarcinogenesisen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.titleBicyclol: A useful agent for chemoprevention of hepatocellular carcinoma?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1538-4047&volume=5&spage=1674&epage=6&date=2006&atitle=Bicyclol:+a+useful+agent+for+chemoprevention+of+hepatocellular+carcinoma?+en_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.4161/cbt.5.12.3737-
dc.identifier.scopuseid_2-s2.0-33846998631en_HK
dc.identifier.hkuros132106en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846998631&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1674en_HK
dc.identifier.epage1676en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, Q=8590747200en_HK
dc.identifier.scopusauthoridSong, Y=55494037600en_HK
dc.identifier.scopusauthoridZhou, Y=7405364644en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK

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