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Article: Smoking, homocysteine and degree of arteriolar retinopathy

TitleSmoking, homocysteine and degree of arteriolar retinopathy
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2005, v. 183 n. 1, p. 95-100 How to Cite?
AbstractIt has been demonstrated that higher degree of arteriolar retinopathy is associated with greater cardiovascular risk, and hyperhomocysteinaemia is also related to increased cardiovascular risk, but interacts with other risk factors, particularly smoking. It still remains unclear regarding relationships of smoking, fasting plasma total homocysteine (tHcy) levels and arteriolar retinopathy. This study was aimed to investigate the relationship and influence of smoking and tHcy levels on degree of arteriolar retinopathy. Two hundred and forty-three subjects were enrolled from an annual health examination. The arteriolar retinopathy was examined by direct ophthalmoscopy. Dundett ANOVA showed that geometric mean of tHcy levels were 11.5 ± 1.54 versus 11.2 ± 1.41 versus 17.6 ± 1.92 (P1 = 0.883, P2 = 0.001) in subjects with no arteriolar retinopathy (as control group), grades I and II retinopathy, respectively. Furthermore, multiple linear regression analysis showed that only smoking consumption (P < 0.001), gender (P = 0.012) and presence of hypertension (P = 0.041) were independent determinants of plasma tHcy levels. After females were excluded, T-test showed a significant differences in tHcy levels (15.6 ± 1.56 μmol/L versus 12.4 ± 1.45 μmol/L, P = 0.003) and in prevalence of grade II retinopathy (25.4% versus 9.3%, P = 0.029), but no difference in other variables or prevalence of overall retinopathy between smokers and non-smokers. Finally, logistic regression showed that smoking (OR 4.19, 95% CI 1.17-15.0) was a stronger predictor than hyperhomocysteinaemia (OR 2.14, 95% CI 0.85-5.41) for presence of grade II retinopathy. This study showed that smoking was related to increased plasma tHcy levels in subjects with grade II retinopathy, and it could independently contribute to facilitating the progression of arteriolar retinopathy. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77948
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHu, Ren_HK
dc.contributor.authorZhang, XXen_HK
dc.contributor.authorWang, WQen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T07:37:30Z-
dc.date.available2010-09-06T07:37:30Z-
dc.date.issued2005en_HK
dc.identifier.citationAtherosclerosis, 2005, v. 183 n. 1, p. 95-100en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77948-
dc.description.abstractIt has been demonstrated that higher degree of arteriolar retinopathy is associated with greater cardiovascular risk, and hyperhomocysteinaemia is also related to increased cardiovascular risk, but interacts with other risk factors, particularly smoking. It still remains unclear regarding relationships of smoking, fasting plasma total homocysteine (tHcy) levels and arteriolar retinopathy. This study was aimed to investigate the relationship and influence of smoking and tHcy levels on degree of arteriolar retinopathy. Two hundred and forty-three subjects were enrolled from an annual health examination. The arteriolar retinopathy was examined by direct ophthalmoscopy. Dundett ANOVA showed that geometric mean of tHcy levels were 11.5 ± 1.54 versus 11.2 ± 1.41 versus 17.6 ± 1.92 (P1 = 0.883, P2 = 0.001) in subjects with no arteriolar retinopathy (as control group), grades I and II retinopathy, respectively. Furthermore, multiple linear regression analysis showed that only smoking consumption (P < 0.001), gender (P = 0.012) and presence of hypertension (P = 0.041) were independent determinants of plasma tHcy levels. After females were excluded, T-test showed a significant differences in tHcy levels (15.6 ± 1.56 μmol/L versus 12.4 ± 1.45 μmol/L, P = 0.003) and in prevalence of grade II retinopathy (25.4% versus 9.3%, P = 0.029), but no difference in other variables or prevalence of overall retinopathy between smokers and non-smokers. Finally, logistic regression showed that smoking (OR 4.19, 95% CI 1.17-15.0) was a stronger predictor than hyperhomocysteinaemia (OR 2.14, 95% CI 0.85-5.41) for presence of grade II retinopathy. This study showed that smoking was related to increased plasma tHcy levels in subjects with grade II retinopathy, and it could independently contribute to facilitating the progression of arteriolar retinopathy. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.rightsAtherosclerosis . Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshArterioles - pathologyen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHomocysteine - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperhomocysteinemia - complications - epidemiologyen_HK
dc.subject.meshHypertension - epidemiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshOphthalmoscopyen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRetinal Diseases - blood - diagnosis - epidemiology - etiologyen_HK
dc.subject.meshRetinal Vessels - pathologyen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSampling Studiesen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.titleSmoking, homocysteine and degree of arteriolar retinopathyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=183&issue=1&spage=95&epage=100&date=2005&atitle=Smoking,+homocysteine+and+degree+of+arteriolar+retinopathy.en_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2005.01.053en_HK
dc.identifier.pmid16216592-
dc.identifier.scopuseid_2-s2.0-26244456942en_HK
dc.identifier.hkuros114986en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26244456942&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume183en_HK
dc.identifier.issue1en_HK
dc.identifier.spage95en_HK
dc.identifier.epage100en_HK
dc.identifier.isiWOS:000233100300011-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridHu, R=55163131900en_HK
dc.identifier.scopusauthoridZhang, XX=8944669200en_HK
dc.identifier.scopusauthoridWang, WQ=7501758106en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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