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Article: Peritoneal function: The role of aquaporins

TitlePeritoneal function: The role of aquaporins
Authors
KeywordsAquaporin-1
Aquaporin-3
Sodium sieving
Ultrafiltration failure
Issue Date2003
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
Peritoneal Dialysis International, 2003, v. 23 SUPPL. 2, p. S20-S25 How to Cite?
AbstractThe aquaporins (AQPs) constitute a large family of water channels that play a part in transcellular water movement in many tissues. They are particularly abundant and important in the kidney and the lung. Derangement of AQP structure or function leads to a variety of water-balance disorders. Aquaporin-1 (AQP1) is constitutively expressed in the endothelial cells of the capillaries and venules that provide the ultrasmall pores predicted by the three-pore model of water movement during peritoneal dialysis. The ultrasmall pores are critical for ultrafiltration. In addition, AQP1 and AQP3 are constitutively expressed in peritoneal mesothelial cells. The expression of those AQPs is upregulated by hyperosmolality. Reduced expression or function of AQP1 may be responsible for some cases of ultrafiltration failure, but further evidence is required to establish that link.
Persistent Identifierhttp://hdl.handle.net/10722/77877
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorLeung, JCen_HK
dc.date.accessioned2010-09-06T07:36:44Z-
dc.date.available2010-09-06T07:36:44Z-
dc.date.issued2003en_HK
dc.identifier.citationPeritoneal Dialysis International, 2003, v. 23 SUPPL. 2, p. S20-S25en_HK
dc.identifier.issn0896-8608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77877-
dc.description.abstractThe aquaporins (AQPs) constitute a large family of water channels that play a part in transcellular water movement in many tissues. They are particularly abundant and important in the kidney and the lung. Derangement of AQP structure or function leads to a variety of water-balance disorders. Aquaporin-1 (AQP1) is constitutively expressed in the endothelial cells of the capillaries and venules that provide the ultrasmall pores predicted by the three-pore model of water movement during peritoneal dialysis. The ultrasmall pores are critical for ultrafiltration. In addition, AQP1 and AQP3 are constitutively expressed in peritoneal mesothelial cells. The expression of those AQPs is upregulated by hyperosmolality. Reduced expression or function of AQP1 may be responsible for some cases of ultrafiltration failure, but further evidence is required to establish that link.en_HK
dc.languageengen_HK
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.comen_HK
dc.relation.ispartofPeritoneal Dialysis Internationalen_HK
dc.subjectAquaporin-1en_HK
dc.subjectAquaporin-3en_HK
dc.subjectSodium sievingen_HK
dc.subjectUltrafiltration failureen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAquaporins - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPeritoneum - physiologyen_HK
dc.titlePeritoneal function: The role of aquaporinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0896-8608&volume=23 &issue=Suppl 2&spage=S20&epage=S25&date=2003&atitle=Peritoneal+function:+the+role+of+aquaporinsen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JC: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JC=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17986548-
dc.identifier.scopuseid_2-s2.0-0347765926en_HK
dc.identifier.hkuros87430en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347765926&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issueSUPPL. 2en_HK
dc.identifier.spageS20en_HK
dc.identifier.epageS25en_HK
dc.identifier.isiWOS:000188533200004-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLam, MF=35300050600en_HK
dc.identifier.scopusauthoridLeung, JC=7202180349en_HK

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