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Article: Natural killer cell neoplasms

TitleNatural killer cell neoplasms
Authors
Issue Date2004
Citation
Clinical Lymphoma, 2004, v. 5 n. 3, p. 197-201 How to Cite?
AbstractLymphoid neoplasms that are derived from natural killer (NK) cells are uncommon but distinct clinicopathologic disease entities. Three types have been recognized and categorized in the latest World Health Organization classification: extranodal NK cell lymphoma, nasal-type; aggressive NK cell leukemia; and blastic NK cell lymphoma. All NK tumor cells express the NK cell marker CD56, but they lack the expression of surface CD3 and the rearrangement of T-cell receptor genes, which distinguish them from T-lymphoid neoplasms. There is also a strong association with the Epstein-Barr virus, except in blastic NK cell lymphoma. Extranodal involvement by the NK cell tumor is common, especially in the nasal cavity, the skin, and the gastrointestinal tract. All 3 NK cell neoplasms are characterized by aggressive clinical course and poor response to treatment. Although the optimal treatment modality remains to be determined, good initial response to combined radiation therapy and chemotherapy has been observed in localized disease. Further studies in the basic biology of the NK cell and the pathology of NK cell neoplasms may shed light on the development of newer and more effective therapy.
Persistent Identifierhttp://hdl.handle.net/10722/77864
ISSN
2007 Impact Factor: 3.105
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, Een_HK
dc.contributor.authorLiang, RHSen_HK
dc.date.accessioned2010-09-06T07:36:35Z-
dc.date.available2010-09-06T07:36:35Z-
dc.date.issued2004en_HK
dc.identifier.citationClinical Lymphoma, 2004, v. 5 n. 3, p. 197-201en_HK
dc.identifier.issn1526-9655en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77864-
dc.description.abstractLymphoid neoplasms that are derived from natural killer (NK) cells are uncommon but distinct clinicopathologic disease entities. Three types have been recognized and categorized in the latest World Health Organization classification: extranodal NK cell lymphoma, nasal-type; aggressive NK cell leukemia; and blastic NK cell lymphoma. All NK tumor cells express the NK cell marker CD56, but they lack the expression of surface CD3 and the rearrangement of T-cell receptor genes, which distinguish them from T-lymphoid neoplasms. There is also a strong association with the Epstein-Barr virus, except in blastic NK cell lymphoma. Extranodal involvement by the NK cell tumor is common, especially in the nasal cavity, the skin, and the gastrointestinal tract. All 3 NK cell neoplasms are characterized by aggressive clinical course and poor response to treatment. Although the optimal treatment modality remains to be determined, good initial response to combined radiation therapy and chemotherapy has been observed in localized disease. Further studies in the basic biology of the NK cell and the pathology of NK cell neoplasms may shed light on the development of newer and more effective therapy.en_HK
dc.languageengen_HK
dc.relation.ispartofClinical Lymphomaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshB-Lymphocytes - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKiller Cells, Natural - pathologyen_HK
dc.subject.meshLymphoma - immunology - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshSkin Neoplasms - immunology - pathologyen_HK
dc.subject.meshT-Lymphocytes - immunologyen_HK
dc.titleNatural killer cell neoplasmsen_HK
dc.typeArticleen_HK
dc.identifier.emailTse, E:ewctse@hku.hken_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.authorityTse, E=rp00471en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3816/CLM.2004.n.027-
dc.identifier.pmid15636697-
dc.identifier.scopuseid_2-s2.0-13644261887en_HK
dc.identifier.hkuros99050en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13644261887&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue3en_HK
dc.identifier.spage197en_HK
dc.identifier.epage201en_HK
dc.identifier.isiWOS:000226109000014-
dc.identifier.scopusauthoridTse, E=7005019454en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK

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