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Article: A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major

TitleA T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major
Authors
KeywordsMagnetic resonance
Thalassemia
Issue Date2008
PublisherFondazione Ferrata Storti.
Citation
Haematologica, 2008, v. 93 n. 1, p. 116-119 How to Cite?
AbstractWe studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (β cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve β cell reserve and prevent pancreatic atrophy. ©2008 Ferrata Storti Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/77829
ISSN
2015 Impact Factor: 6.671
2015 SCImago Journal Rankings: 3.010
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorChu, Wen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, WKen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2010-09-06T07:36:12Z-
dc.date.available2010-09-06T07:36:12Z-
dc.date.issued2008en_HK
dc.identifier.citationHaematologica, 2008, v. 93 n. 1, p. 116-119en_HK
dc.identifier.issn0390-6078en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77829-
dc.description.abstractWe studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (β cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve β cell reserve and prevent pancreatic atrophy. ©2008 Ferrata Storti Foundation.en_HK
dc.languageengen_HK
dc.publisherFondazione Ferrata Storti.en_HK
dc.relation.ispartofHaematologicaen_HK
dc.subjectMagnetic resonanceen_HK
dc.subjectThalassemiaen_HK
dc.titleA T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia majoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0390-6078&volume=93&issue=1&spage=116&epage=119 &date=2008&atitle=A+T2*+magnetic+resonance+imaging+study+of+pancreatic+iron+overload+in+thalassemia+majoren_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.3324/haematol.11768en_HK
dc.identifier.scopuseid_2-s2.0-38549150853en_HK
dc.identifier.hkuros145661en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38549150853&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue1en_HK
dc.identifier.spage116en_HK
dc.identifier.epage119en_HK
dc.identifier.isiWOS:000252434600019-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLam, WWM=13410486800en_HK
dc.identifier.scopusauthoridChu, W=7402227871en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, WK=14055124500en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK

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