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Article: Hairy cell leukemia in Hong Kong Chinese: A 12-year retrospective survey

TitleHairy cell leukemia in Hong Kong Chinese: A 12-year retrospective survey
Authors
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182
Citation
Hematological Oncology, 2000, v. 18 n. 4, p. 155-159 How to Cite?
AbstractBackground: Hairy cell leukemia (HCL) is a unique chronic B cell lymphoproliferative disease (B-LPD), with distinct clinical and pathological features, and excellent treatment response to 2-chlorodeoxy-adenosine (2-CDA) and pentostatin. There have been few reports of HCL from oriental countries. Patients and methods: A retrospective survey of HCL in six major hematology units in Hong Kong over a 12-year period. Results: There were 18 cases of HCL identified. Most patients presented with fever, splenomegaly and monocytopenia. Lymphadenopathy was present in three patients, and open biopsy revealed tuberculosis infection in two cases. Seven cases received interferon and 12 cases received 2-CDA. Four patients died from bronchogenic carcinoma, cerebral vascular accident, fulminant hepatitis B virus reactivation and malignant melanoma. The remaining 14 patients are in clinical remission at a median of 6 years' follow-up; two are also surviving from second malignancies (thyroid papillary carcinoma and renal cell carcinoma). Conclusions: Parallel to the low incidence of B-LPD in Chinese, the incidence of HCL (0.035/100000 population per year) is much lower than in Western series. Other clinical features such as male dominance, clinical presentation, response to 2-CDA treatment, and association with second malignancy are similar to Western reports. However, two common complications in the Chinese population are the fulminant reactivation of hepatitis B infection and disseminated tuberculosis infection. © 2000 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77825
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorMak, YKen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorLei, KIen_HK
dc.contributor.authorNg, MHen_HK
dc.contributor.authorChan, JCWen_HK
dc.contributor.authorLin, SYen_HK
dc.contributor.authorLee, KKen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:36:09Z-
dc.date.available2010-09-06T07:36:09Z-
dc.date.issued2000en_HK
dc.identifier.citationHematological Oncology, 2000, v. 18 n. 4, p. 155-159en_HK
dc.identifier.issn0278-0232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77825-
dc.description.abstractBackground: Hairy cell leukemia (HCL) is a unique chronic B cell lymphoproliferative disease (B-LPD), with distinct clinical and pathological features, and excellent treatment response to 2-chlorodeoxy-adenosine (2-CDA) and pentostatin. There have been few reports of HCL from oriental countries. Patients and methods: A retrospective survey of HCL in six major hematology units in Hong Kong over a 12-year period. Results: There were 18 cases of HCL identified. Most patients presented with fever, splenomegaly and monocytopenia. Lymphadenopathy was present in three patients, and open biopsy revealed tuberculosis infection in two cases. Seven cases received interferon and 12 cases received 2-CDA. Four patients died from bronchogenic carcinoma, cerebral vascular accident, fulminant hepatitis B virus reactivation and malignant melanoma. The remaining 14 patients are in clinical remission at a median of 6 years' follow-up; two are also surviving from second malignancies (thyroid papillary carcinoma and renal cell carcinoma). Conclusions: Parallel to the low incidence of B-LPD in Chinese, the incidence of HCL (0.035/100000 population per year) is much lower than in Western series. Other clinical features such as male dominance, clinical presentation, response to 2-CDA treatment, and association with second malignancy are similar to Western reports. However, two common complications in the Chinese population are the fulminant reactivation of hepatitis B infection and disseminated tuberculosis infection. © 2000 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182en_HK
dc.relation.ispartofHematological Oncologyen_HK
dc.rightsHematological Oncology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Hairy Cell - epidemiology - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titleHairy cell leukemia in Hong Kong Chinese: A 12-year retrospective surveyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-0232&volume=18&spage=155&epage=159&date=2000&atitle=Hairy+cell+leukemia+in+Hong+Kong+Chinese:+a+12-year+retrospective+surveyen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1099-1069(200012)18:4<155::AID-HON668>3.0.CO;2-Hen_HK
dc.identifier.pmid11135356-
dc.identifier.scopuseid_2-s2.0-0034495020en_HK
dc.identifier.hkuros60010en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034495020&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue4en_HK
dc.identifier.spage155en_HK
dc.identifier.epage159en_HK
dc.identifier.isiWOS:000166442800003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridMak, YK=36841758500en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridLei, KI=7102208067en_HK
dc.identifier.scopusauthoridNg, MH=35292609300en_HK
dc.identifier.scopusauthoridChan, JCW=9940606800en_HK
dc.identifier.scopusauthoridLin, SY=11440318200en_HK
dc.identifier.scopusauthoridLee, KK=7501503975en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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