File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis

TitlePotent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis
Authors
KeywordsCaspase-independent apoptosis
Gene-virotherapy
XAF1
ZD55
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cgt
Citation
Cancer Gene Therapy, 2007, v. 14 n. 1, p. 82-90 How to Cite?
Abstract
XAF1 is a newly identified tumor-suppressor gene that can antagonize XIAP and sensitize cells to other cell death triggers. In this study, we utilized ZD55, a conditionally replicative adenovirus (CRAd) similar to ONYX-015 as the vector to transfer XAF1 into the tumor cells to evaluate its antitumor efficacy in vitro and in vivo. Potent and specific cytopathic effect (CPE) was observed upon infection with ZD55-XAF1 in tumor cell lines. Importantly, ZD55-XAF1 exhibited a superior suppression of tumor growth in an animal model of colorectal carcinoma in nude mice compared with Ad-XAF1 (E1-deleted replication-defective viral) and ONYX-015. Complete eradication of the established tumors was observed in four of eight mice. Our data also showed that infection with ZD55-XAF1 resulted in caspase-independent apoptosis. Although caspase-3, poly(ADP-ribose) polymerase were mildly activated in response to ZD55-XAF1 infection, pretreatment with pan-caspase inhibitor hardly influence its apoptosis-inducing activity. In summary, our study strongly suggested that ZD55-XAF1 could serve as an effective gene-virotherapy strategy and has highly potential against human cancers. © 2007 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77818
ISSN
2013 Impact Factor: 2.553
2013 SCImago Journal Rankings: 1.064
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQi, Ren_HK
dc.contributor.authorGu, Jen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorYang, Ken_HK
dc.contributor.authorLi, Ben_HK
dc.contributor.authorFan, Jen_HK
dc.contributor.authorWang, Cen_HK
dc.contributor.authorHe, Zen_HK
dc.contributor.authorQiao, Len_HK
dc.contributor.authorLin, Zen_HK
dc.contributor.authorLiu, XYen_HK
dc.date.accessioned2010-09-06T07:36:04Z-
dc.date.available2010-09-06T07:36:04Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer Gene Therapy, 2007, v. 14 n. 1, p. 82-90en_HK
dc.identifier.issn0929-1903en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77818-
dc.description.abstractXAF1 is a newly identified tumor-suppressor gene that can antagonize XIAP and sensitize cells to other cell death triggers. In this study, we utilized ZD55, a conditionally replicative adenovirus (CRAd) similar to ONYX-015 as the vector to transfer XAF1 into the tumor cells to evaluate its antitumor efficacy in vitro and in vivo. Potent and specific cytopathic effect (CPE) was observed upon infection with ZD55-XAF1 in tumor cell lines. Importantly, ZD55-XAF1 exhibited a superior suppression of tumor growth in an animal model of colorectal carcinoma in nude mice compared with Ad-XAF1 (E1-deleted replication-defective viral) and ONYX-015. Complete eradication of the established tumors was observed in four of eight mice. Our data also showed that infection with ZD55-XAF1 resulted in caspase-independent apoptosis. Although caspase-3, poly(ADP-ribose) polymerase were mildly activated in response to ZD55-XAF1 infection, pretreatment with pan-caspase inhibitor hardly influence its apoptosis-inducing activity. In summary, our study strongly suggested that ZD55-XAF1 could serve as an effective gene-virotherapy strategy and has highly potential against human cancers. © 2007 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cgten_HK
dc.relation.ispartofCancer Gene Therapyen_HK
dc.subjectCaspase-independent apoptosisen_HK
dc.subjectGene-virotherapyen_HK
dc.subjectXAF1en_HK
dc.subjectZD55en_HK
dc.titlePotent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-1903&volume=14&spage=82&epage=90&date=2007&atitle=Potent+antitumor+efficacy+of+XAF1+delivered+by+conditionally+replicative+adenovirus+vector+via+caspase-independent+apoptosisen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.cgt.7700992en_HK
dc.identifier.pmid17008933en_HK
dc.identifier.scopuseid_2-s2.0-33845619573en_HK
dc.identifier.hkuros132102en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845619573&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue1en_HK
dc.identifier.spage82en_HK
dc.identifier.epage90en_HK
dc.identifier.isiWOS:000242850400010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridQi, R=55111639100en_HK
dc.identifier.scopusauthoridGu, J=7403129395en_HK
dc.identifier.scopusauthoridZhang, Z=8526052900en_HK
dc.identifier.scopusauthoridYang, K=55212645800en_HK
dc.identifier.scopusauthoridLi, B=7410079183en_HK
dc.identifier.scopusauthoridFan, J=8637944400en_HK
dc.identifier.scopusauthoridWang, C=8600595000en_HK
dc.identifier.scopusauthoridHe, Z=15725157600en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridLin, Z=7404230166en_HK
dc.identifier.scopusauthoridLiu, XY=7409290398en_HK
dc.identifier.citeulike878691-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats