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Article: Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung

TitleCapecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung
Authors
Issue Date2009
PublisherLippincott Williams & Wilkins.
Citation
Journal Of Thoracic Oncology, 2009, v. 4 n. 9, p. 1174-1177 How to Cite?
AbstractLymphoepithelioma-like carcinoma (LELC) of lung has previously demonstrated good clinical response to 5-fluorouracil containing chemotherapy regimen, similar to the observation in undifferentiated nasopharyngeal carcinoma. Capecitabine, which is converted into active 5-fluorouracil within tumor cells, has been found effective in colorectal, breast, and recently nasopharyngeal carcinomas. We report our experience in five patients with advanced or metastatic LELC of lung who were treated with single agent capecitabine as salvage chemotherapy. The finding of disease control in three of five patients, especially with exceptionally durable stable disease (14.8 months) in one patient, suggests the potential clinical activity of capecitabine in LELC of lung. Future studies on capecitabine-containing chemotherapy regimens in LELC of lung are warranted. © 2009 International Association for the Study of Lung Cancer.
Persistent Identifierhttp://hdl.handle.net/10722/77781
ISSN
2015 Impact Factor: 5.04
2015 SCImago Journal Rankings: 2.597
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, JCen_HK
dc.contributor.authorLam, DCen_HK
dc.contributor.authorWong, MKen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorIp, MSen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-06T07:35:39Z-
dc.date.available2010-09-06T07:35:39Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Thoracic Oncology, 2009, v. 4 n. 9, p. 1174-1177en_HK
dc.identifier.issn1556-0864en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77781-
dc.description.abstractLymphoepithelioma-like carcinoma (LELC) of lung has previously demonstrated good clinical response to 5-fluorouracil containing chemotherapy regimen, similar to the observation in undifferentiated nasopharyngeal carcinoma. Capecitabine, which is converted into active 5-fluorouracil within tumor cells, has been found effective in colorectal, breast, and recently nasopharyngeal carcinomas. We report our experience in five patients with advanced or metastatic LELC of lung who were treated with single agent capecitabine as salvage chemotherapy. The finding of disease control in three of five patients, especially with exceptionally durable stable disease (14.8 months) in one patient, suggests the potential clinical activity of capecitabine in LELC of lung. Future studies on capecitabine-containing chemotherapy regimens in LELC of lung are warranted. © 2009 International Association for the Study of Lung Cancer.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins.en_HK
dc.relation.ispartofJournal of Thoracic Oncologyen_HK
dc.rightsJournal of Thoracic Oncology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - drug therapyen_HK
dc.subject.meshDeoxycytidine - analogs & derivatives - therapeutic useen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFluorouracil - analogs & derivatives - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLung Neoplasms - drug therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSalvage Therapyen_HK
dc.titleCapecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lungen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1556-0864&volume=4&issue=9&spage=1174&epage=1177&date=2009&atitle=Capecitabine+as+salvage+treatment+for+lymphoepithelioma-like+carcinoma+of+lungen_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.emailLam, DC:lamcl@hkucc.hku.hken_HK
dc.identifier.emailIp, MS:msmip@hku.hken_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.identifier.authorityLam, DC=rp01345en_HK
dc.identifier.authorityIp, MS=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/JTO.0b013e3181b28f15en_HK
dc.identifier.pmid19704339-
dc.identifier.scopuseid_2-s2.0-69549116225en_HK
dc.identifier.hkuros167339en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69549116225&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1174en_HK
dc.identifier.epage1177en_HK
dc.identifier.eissn1556-1380-
dc.identifier.isiWOS:000269495500018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridLam, DC=7201749615en_HK
dc.identifier.scopusauthoridWong, MK=23480818200en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridIp, MS=7102423259en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK

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