Article: Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung

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TitleCapecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung
AuthorsHo, JC1
Lam, DC1
Wong, MK1
Lam, B1
Ip, MS1
Lam, WK1
Issue Date2009
PublisherLippincott Williams & Wilkins.
CitationJournal Of Thoracic Oncology, 2009, v. 4 n. 9, p. 1174-1177 [How to Cite?]
DOI: http://dx.doi.org/10.1097/JTO.0b013e3181b28f15
AbstractLymphoepithelioma-like carcinoma (LELC) of lung has previously demonstrated good clinical response to 5-fluorouracil containing chemotherapy regimen, similar to the observation in undifferentiated nasopharyngeal carcinoma. Capecitabine, which is converted into active 5-fluorouracil within tumor cells, has been found effective in colorectal, breast, and recently nasopharyngeal carcinomas. We report our experience in five patients with advanced or metastatic LELC of lung who were treated with single agent capecitabine as salvage chemotherapy. The finding of disease control in three of five patients, especially with exceptionally durable stable disease (14.8 months) in one patient, suggests the potential clinical activity of capecitabine in LELC of lung. Future studies on capecitabine-containing chemotherapy regimens in LELC of lung are warranted. © 2009 International Association for the Study of Lung Cancer.
ISSN1556-0864
2011 Impact Factor: 3.661
2011 SCImago Journal Rankings: 0.337
DOIhttp://dx.doi.org/10.1097/JTO.0b013e3181b28f15
ISI Accession Number IDWOS:000269495500018
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, JC
dc.contributor.authorLam, DC
dc.contributor.authorWong, MK
dc.contributor.authorLam, B
dc.contributor.authorIp, MS
dc.contributor.authorLam, WK
dc.date.accessioned2010-09-06T07:35:39Z
dc.date.available2010-09-06T07:35:39Z
dc.date.issued2009
dc.description.abstractLymphoepithelioma-like carcinoma (LELC) of lung has previously demonstrated good clinical response to 5-fluorouracil containing chemotherapy regimen, similar to the observation in undifferentiated nasopharyngeal carcinoma. Capecitabine, which is converted into active 5-fluorouracil within tumor cells, has been found effective in colorectal, breast, and recently nasopharyngeal carcinomas. We report our experience in five patients with advanced or metastatic LELC of lung who were treated with single agent capecitabine as salvage chemotherapy. The finding of disease control in three of five patients, especially with exceptionally durable stable disease (14.8 months) in one patient, suggests the potential clinical activity of capecitabine in LELC of lung. Future studies on capecitabine-containing chemotherapy regimens in LELC of lung are warranted. © 2009 International Association for the Study of Lung Cancer.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Thoracic Oncology, 2009, v. 4 n. 9, p. 1174-1177 [How to Cite?]
DOI: http://dx.doi.org/10.1097/JTO.0b013e3181b28f15
dc.identifier.doihttp://dx.doi.org/10.1097/JTO.0b013e3181b28f15
dc.identifier.epage1177
dc.identifier.hkuros167339
dc.identifier.isiWOS:000269495500018
dc.identifier.issn1556-0864
2011 Impact Factor: 3.661
2011 SCImago Journal Rankings: 0.337
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid19704339
dc.identifier.scopuseid_2-s2.0-69549116225
dc.identifier.spage1174
dc.identifier.urihttp://hdl.handle.net/10722/77781
dc.identifier.volume4
dc.languageeng
dc.publisherLippincott Williams & Wilkins.
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Thoracic Oncology
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Thoracic Oncology. Copyright © Lippincott Williams & Wilkins.
dc.subject.meshAged
dc.subject.meshCarcinoma, Non-Small-Cell Lung - drug therapy
dc.subject.meshDeoxycytidine - analogs & derivatives - therapeutic use
dc.subject.meshDisease Progression
dc.subject.meshFemale
dc.subject.meshFluorouracil - analogs & derivatives - therapeutic use
dc.subject.meshHumans
dc.subject.meshLung Neoplasms - drug therapy
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshSalvage Therapy
dc.titleCapecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong