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Article: The Holmes-Adie plus syndrome

TitleThe Holmes-Adie plus syndrome
Authors
Issue Date2000
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jocn
Citation
Journal Of Clinical Neuroscience, 2000, v. 7 n. 5, p. 452 How to Cite?
AbstractA clinical syndrome of tonic pupil associated with tendon areflexia was first described by Holmes and Adie; autonomic neuropathy and peripheral neuropathy can be associated. The postulated mechanism of areflexia in Holmes-Adie syndrome is a synaptic disorder of the spinal reflex pathways. We report a case of a Holmes-Adie syndrome variant with hitherto unreported cranial neuropathy. A 41 year old woman developed insidious onset of sensory symptoms related to her left trigeminal and chorda tympani nerves over a few months. Physical examination showed generalised tendon areflexia and a left sided Adie's pupil. Imaging did not reveal any structural abnormality. Electrophysiological studies demonstrated an absent blink reflex on stimulating the left supraorbital and infraorbital nerves. These findings were suggestive of a dysfunction affecting the brain stem reflex arc. The pathophysiological process of Holmes-Adie syndrome may be more widespread than previously thought. (C) 2000 Harcourt Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77780
ISSN
2015 Impact Factor: 1.387
2015 SCImago Journal Rankings: 0.609
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, Wen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2010-09-06T07:35:38Z-
dc.date.available2010-09-06T07:35:38Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Clinical Neuroscience, 2000, v. 7 n. 5, p. 452en_HK
dc.identifier.issn0967-5868en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77780-
dc.description.abstractA clinical syndrome of tonic pupil associated with tendon areflexia was first described by Holmes and Adie; autonomic neuropathy and peripheral neuropathy can be associated. The postulated mechanism of areflexia in Holmes-Adie syndrome is a synaptic disorder of the spinal reflex pathways. We report a case of a Holmes-Adie syndrome variant with hitherto unreported cranial neuropathy. A 41 year old woman developed insidious onset of sensory symptoms related to her left trigeminal and chorda tympani nerves over a few months. Physical examination showed generalised tendon areflexia and a left sided Adie's pupil. Imaging did not reveal any structural abnormality. Electrophysiological studies demonstrated an absent blink reflex on stimulating the left supraorbital and infraorbital nerves. These findings were suggestive of a dysfunction affecting the brain stem reflex arc. The pathophysiological process of Holmes-Adie syndrome may be more widespread than previously thought. (C) 2000 Harcourt Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jocnen_HK
dc.relation.ispartofJournal of Clinical Neuroscienceen_HK
dc.subject.meshAdie Syndrome - diagnosis - physiopathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshTrigeminal Nerveen_HK
dc.titleThe Holmes-Adie plus syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0967-5868&volume=7&spage=452&epage=&date=2000&atitle=The+Holmes-Adie+plus+syndromeen_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1054/jocn.1999.0233en_HK
dc.identifier.pmid10942670-
dc.identifier.scopuseid_2-s2.0-0033812651en_HK
dc.identifier.hkuros52562en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033812651&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue5en_HK
dc.identifier.spage452en_HK
dc.identifier.epage452en_HK
dc.identifier.isiWOS:000089248000016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMak, W=22948344000en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK

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