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Article: Philadelphia (Ph) chromosome-positive chronic myeloid leukaemia relapsing as Ph-negative leukaemia after allogeneic bone marrow transplantation

TitlePhiladelphia (Ph) chromosome-positive chronic myeloid leukaemia relapsing as Ph-negative leukaemia after allogeneic bone marrow transplantation
Authors
Au, WYLie, AKWMa, SKWan, TSKLiang, RLeung, YHKwong, YL
KeywordsBMT
CML
Ph-negative leukaemia
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2001, v. 114 n. 2, p. 365-368 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.2001.02960.x
AbstractTwo patients with Philadelphia chromosome-positive (Ph +) chronic myeloid leukaemia (CML) relapsed 1.5 and 5 years after allogeneic bone marrow transplantation (BMT). Although the leukaemias were of recipient origin, t(9;22) could no longer be detected using conventional cytogenetics/fluorescence in situ hybridization or molecularly. Both patients responded to immunotherapy with donor lymphocytes/peripheral blood stem cells, although one patient ultimately relapsed again. These patients were similar to the occurrence of Ph - leukaemias previously described in Ph + CML after treatment with interferon or autologous BMT, and might be relevant in the pathogenesis and monitoring of treatment after BMT in CML.
Persistent Identifierhttp://hdl.handle.net/10722/77735
ISSN
0007-1048
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.574
ISI Accession Number ID
WOS:000170570200018
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLeung, YHen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:35:09Z-
dc.date.available2010-09-06T07:35:09Z-
dc.date.issued2001en_HK
dc.identifier.citationBritish Journal Of Haematology, 2001, v. 114 n. 2, p. 365-368en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77735-
dc.description.abstractTwo patients with Philadelphia chromosome-positive (Ph +) chronic myeloid leukaemia (CML) relapsed 1.5 and 5 years after allogeneic bone marrow transplantation (BMT). Although the leukaemias were of recipient origin, t(9;22) could no longer be detected using conventional cytogenetics/fluorescence in situ hybridization or molecularly. Both patients responded to immunotherapy with donor lymphocytes/peripheral blood stem cells, although one patient ultimately relapsed again. These patients were similar to the occurrence of Ph - leukaemias previously described in Ph + CML after treatment with interferon or autologous BMT, and might be relevant in the pathogenesis and monitoring of treatment after BMT in CML.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectBMT-
dc.subjectCML-
dc.subjectPh-negative leukaemia-
dc.subject.meshAdulten_HK
dc.subject.meshBlood Transfusion, Autologousen_HK
dc.subject.meshBone Marrow Transplantationen_HK
dc.subject.meshFusion Proteins, bcr-ablen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics - therapyen_HK
dc.subject.meshLymphocyte Transfusionen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPhiladelphia Chromosomeen_HK
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - geneticsen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titlePhiladelphia (Ph) chromosome-positive chronic myeloid leukaemia relapsing as Ph-negative leukaemia after allogeneic bone marrow transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=114&issue=2&spage=365&epage=368&date=2001&atitle=Philadelphia+(Ph)+chromosome-positive+chronic+myeloid+leukaemia+relapsing+as+Ph-negative+leukaemia+after+allogeneic+bone+marrow+transplantationen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailLeung, YH:ayhleung@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityLeung, YH=rp00265en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2141.2001.02960.xen_HK
dc.identifier.pmid11529857-
dc.identifier.scopuseid_2-s2.0-0034888052en_HK
dc.identifier.hkuros67008en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034888052&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue2en_HK
dc.identifier.spage365en_HK
dc.identifier.epage368en_HK
dc.identifier.isiWOS:000170570200018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLeung, YH=7403012668en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0007-1048-

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