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Article: Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel

TitleManagement and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel
Authors
Issue Date2008
PublisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
Citation
Journal Of Gastroenterology, 2008, v. 43 n. 9, p. 679-686 How to Cite?
Abstract
Background: This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy. Methods: From January 2002 to September 2006, patients with endoscopically proven peptic ulcers/erosions after receiving A + C cotherapy were analyzed. Results: This group consisted of 106 patients (age, 69.3 ± 11.7 years). Ulcers/erosions developed in 27 patients during hospitalization for cardiac events and in 79 patients after hospital discharge. Of 27 patients hospitalized for acute cardiac events, gastrointestinal (GI) bleeding and dyspepsia occurred in 24 and three, respectively. The most common lesion was gastric ulcer. Of 79 discharged patients, GI bleeding and dyspepsia occurred in 64 and 15, respectively. The most common bleeding and dyspeptic lesions were gastric ulcer and gastritis, respectively. Overall, 17 patients underwent endoscopic hemostasis all successfully. A + C cotherapy was continued in 57 patients for a median (interquartile range) of 3.0 (6.2) months. Most were coprescribed a proton pump inhibitor (PPI) (53, 93%). No recurrent GI bleeding was observed. Conclusions: After A + C cotherapy, gastric ulcer or gastritis were the most common endoscopic lesions. The combination of a PPI and endoscopic treatment for ulcer bleeding was highly successful. After patient stabilization, continuation of A + C cotherapy with a PPI appears to be safe. © Springer Japan 2008.
Persistent Identifierhttp://hdl.handle.net/10722/77727
ISSN
2013 Impact Factor: 4.020
2013 SCImago Journal Rankings: 1.724
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, FHen_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorKwanching, CPen_HK
dc.contributor.authorLoo, CKen_HK
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorKng, Cen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:35:04Z-
dc.date.available2010-09-06T07:35:04Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Gastroenterology, 2008, v. 43 n. 9, p. 679-686en_HK
dc.identifier.issn0944-1174en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77727-
dc.description.abstractBackground: This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy. Methods: From January 2002 to September 2006, patients with endoscopically proven peptic ulcers/erosions after receiving A + C cotherapy were analyzed. Results: This group consisted of 106 patients (age, 69.3 ± 11.7 years). Ulcers/erosions developed in 27 patients during hospitalization for cardiac events and in 79 patients after hospital discharge. Of 27 patients hospitalized for acute cardiac events, gastrointestinal (GI) bleeding and dyspepsia occurred in 24 and three, respectively. The most common lesion was gastric ulcer. Of 79 discharged patients, GI bleeding and dyspepsia occurred in 64 and 15, respectively. The most common bleeding and dyspeptic lesions were gastric ulcer and gastritis, respectively. Overall, 17 patients underwent endoscopic hemostasis all successfully. A + C cotherapy was continued in 57 patients for a median (interquartile range) of 3.0 (6.2) months. Most were coprescribed a proton pump inhibitor (PPI) (53, 93%). No recurrent GI bleeding was observed. Conclusions: After A + C cotherapy, gastric ulcer or gastritis were the most common endoscopic lesions. The combination of a PPI and endoscopic treatment for ulcer bleeding was highly successful. After patient stabilization, continuation of A + C cotherapy with a PPI appears to be safe. © Springer Japan 2008.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htmen_HK
dc.relation.ispartofJournal of Gastroenterologyen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - administration & dosage - adverse effectsen_HK
dc.subject.meshAspirin - administration & dosage - adverse effectsen_HK
dc.subject.meshCoronary Disease - therapyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastrointestinal Hemorrhage - therapyen_HK
dc.subject.meshHemostasis, Endoscopicen_HK
dc.subject.meshHospitalizationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPeptic Ulcer - chemically induced - complications - therapyen_HK
dc.subject.meshPlatelet Aggregation Inhibitors - therapeutic useen_HK
dc.subject.meshStentsen_HK
dc.subject.meshTiclopidine - administration & dosage - adverse effects - analogs & derivativesen_HK
dc.titleManagement and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0944-1174&volume=43&issue=9&spage=679&epage=86&date=2008&atitle=Management+and+outcome+of+peptic+ulcers+or+erosions+in+patients+receiving+a+combination+of+aspirin+plus+clopidogrelen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00535-008-2215-4en_HK
dc.identifier.pmid18807129en_HK
dc.identifier.scopuseid_2-s2.0-52749083598en_HK
dc.identifier.hkuros158984en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-52749083598&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue9en_HK
dc.identifier.spage679en_HK
dc.identifier.epage686en_HK
dc.identifier.isiWOS:000259371200005-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridNg, FH=16936078000en_HK
dc.identifier.scopusauthoridChan, P=7403497715en_HK
dc.identifier.scopusauthoridKwanching, CP=25029561100en_HK
dc.identifier.scopusauthoridLoo, CK=7103026584en_HK
dc.identifier.scopusauthoridCheung, TK=7103334158en_HK
dc.identifier.scopusauthoridWong, SY=7404590845en_HK
dc.identifier.scopusauthoridKng, C=7801364659en_HK
dc.identifier.scopusauthoridNg, KM=24080581500en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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