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Article: Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel
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TitleManagement and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel
 
AuthorsNg, FH4
Chan, P2
Kwanching, CP3
Loo, CK1
Cheung, TK2
Wong, SY4
Kng, C4
Ng, KM3
Lai, ST3
Wong, BCY2
 
Issue Date2008
 
PublisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
 
CitationJournal Of Gastroenterology, 2008, v. 43 n. 9, p. 679-686 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00535-008-2215-4
 
AbstractBackground: This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy. Methods: From January 2002 to September 2006, patients with endoscopically proven peptic ulcers/erosions after receiving A + C cotherapy were analyzed. Results: This group consisted of 106 patients (age, 69.3 ± 11.7 years). Ulcers/erosions developed in 27 patients during hospitalization for cardiac events and in 79 patients after hospital discharge. Of 27 patients hospitalized for acute cardiac events, gastrointestinal (GI) bleeding and dyspepsia occurred in 24 and three, respectively. The most common lesion was gastric ulcer. Of 79 discharged patients, GI bleeding and dyspepsia occurred in 64 and 15, respectively. The most common bleeding and dyspeptic lesions were gastric ulcer and gastritis, respectively. Overall, 17 patients underwent endoscopic hemostasis all successfully. A + C cotherapy was continued in 57 patients for a median (interquartile range) of 3.0 (6.2) months. Most were coprescribed a proton pump inhibitor (PPI) (53, 93%). No recurrent GI bleeding was observed. Conclusions: After A + C cotherapy, gastric ulcer or gastritis were the most common endoscopic lesions. The combination of a PPI and endoscopic treatment for ulcer bleeding was highly successful. After patient stabilization, continuation of A + C cotherapy with a PPI appears to be safe. © Springer Japan 2008.
 
ISSN0944-1174
2013 Impact Factor: 4.020
2013 SCImago Journal Rankings: 1.724
 
DOIhttp://dx.doi.org/10.1007/s00535-008-2215-4
 
ISI Accession Number IDWOS:000259371200005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNg, FH
 
dc.contributor.authorChan, P
 
dc.contributor.authorKwanching, CP
 
dc.contributor.authorLoo, CK
 
dc.contributor.authorCheung, TK
 
dc.contributor.authorWong, SY
 
dc.contributor.authorKng, C
 
dc.contributor.authorNg, KM
 
dc.contributor.authorLai, ST
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2010-09-06T07:35:04Z
 
dc.date.available2010-09-06T07:35:04Z
 
dc.date.issued2008
 
dc.description.abstractBackground: This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy. Methods: From January 2002 to September 2006, patients with endoscopically proven peptic ulcers/erosions after receiving A + C cotherapy were analyzed. Results: This group consisted of 106 patients (age, 69.3 ± 11.7 years). Ulcers/erosions developed in 27 patients during hospitalization for cardiac events and in 79 patients after hospital discharge. Of 27 patients hospitalized for acute cardiac events, gastrointestinal (GI) bleeding and dyspepsia occurred in 24 and three, respectively. The most common lesion was gastric ulcer. Of 79 discharged patients, GI bleeding and dyspepsia occurred in 64 and 15, respectively. The most common bleeding and dyspeptic lesions were gastric ulcer and gastritis, respectively. Overall, 17 patients underwent endoscopic hemostasis all successfully. A + C cotherapy was continued in 57 patients for a median (interquartile range) of 3.0 (6.2) months. Most were coprescribed a proton pump inhibitor (PPI) (53, 93%). No recurrent GI bleeding was observed. Conclusions: After A + C cotherapy, gastric ulcer or gastritis were the most common endoscopic lesions. The combination of a PPI and endoscopic treatment for ulcer bleeding was highly successful. After patient stabilization, continuation of A + C cotherapy with a PPI appears to be safe. © Springer Japan 2008.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Gastroenterology, 2008, v. 43 n. 9, p. 679-686 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00535-008-2215-4
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00535-008-2215-4
 
dc.identifier.epage686
 
dc.identifier.hkuros158984
 
dc.identifier.isiWOS:000259371200005
 
dc.identifier.issn0944-1174
2013 Impact Factor: 4.020
2013 SCImago Journal Rankings: 1.724
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmid18807129
 
dc.identifier.scopuseid_2-s2.0-52749083598
 
dc.identifier.spage679
 
dc.identifier.urihttp://hdl.handle.net/10722/77727
 
dc.identifier.volume43
 
dc.languageeng
 
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
 
dc.publisher.placeJapan
 
dc.relation.ispartofJournal of Gastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - administration & dosage - adverse effects
 
dc.subject.meshAspirin - administration & dosage - adverse effects
 
dc.subject.meshCoronary Disease - therapy
 
dc.subject.meshFemale
 
dc.subject.meshGastrointestinal Hemorrhage - therapy
 
dc.subject.meshHemostasis, Endoscopic
 
dc.subject.meshHospitalization
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshPeptic Ulcer - chemically induced - complications - therapy
 
dc.subject.meshPlatelet Aggregation Inhibitors - therapeutic use
 
dc.subject.meshStents
 
dc.subject.meshTiclopidine - administration & dosage - adverse effects - analogs & derivatives
 
dc.titleManagement and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel
 
dc.typeArticle
 
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<contributor.author>Wong, SY</contributor.author>
<contributor.author>Kng, C</contributor.author>
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Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong
  3. Princess Margaret Hospital Hong Kong
  4. Ruttonjee Hospital Hong Kong