Article: Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel

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TitleManagement and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel
AuthorsNg, FH4
Chan, P2
Kwanching, CP3
Loo, CK1
Cheung, TK2
Wong, SY4
Kng, C4
Ng, KM3
Lai, ST3
Wong, BCY2
Issue Date2008
PublisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
CitationJournal Of Gastroenterology, 2008, v. 43 n. 9, p. 679-686 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00535-008-2215-4
AbstractBackground: This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy. Methods: From January 2002 to September 2006, patients with endoscopically proven peptic ulcers/erosions after receiving A + C cotherapy were analyzed. Results: This group consisted of 106 patients (age, 69.3 ± 11.7 years). Ulcers/erosions developed in 27 patients during hospitalization for cardiac events and in 79 patients after hospital discharge. Of 27 patients hospitalized for acute cardiac events, gastrointestinal (GI) bleeding and dyspepsia occurred in 24 and three, respectively. The most common lesion was gastric ulcer. Of 79 discharged patients, GI bleeding and dyspepsia occurred in 64 and 15, respectively. The most common bleeding and dyspeptic lesions were gastric ulcer and gastritis, respectively. Overall, 17 patients underwent endoscopic hemostasis all successfully. A + C cotherapy was continued in 57 patients for a median (interquartile range) of 3.0 (6.2) months. Most were coprescribed a proton pump inhibitor (PPI) (53, 93%). No recurrent GI bleeding was observed. Conclusions: After A + C cotherapy, gastric ulcer or gastritis were the most common endoscopic lesions. The combination of a PPI and endoscopic treatment for ulcer bleeding was highly successful. After patient stabilization, continuation of A + C cotherapy with a PPI appears to be safe. © Springer Japan 2008.
ISSN0944-1174
2011 Impact Factor: 4.16
2011 SCImago Journal Rankings: 0.372
DOIhttp://dx.doi.org/10.1007/s00535-008-2215-4
ISI Accession Number IDWOS:000259371200005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNg, FH
dc.contributor.authorChan, P
dc.contributor.authorKwanching, CP
dc.contributor.authorLoo, CK
dc.contributor.authorCheung, TK
dc.contributor.authorWong, SY
dc.contributor.authorKng, C
dc.contributor.authorNg, KM
dc.contributor.authorLai, ST
dc.contributor.authorWong, BCY
dc.date.accessioned2010-09-06T07:35:04Z
dc.date.available2010-09-06T07:35:04Z
dc.date.issued2008
dc.description.abstractBackground: This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy. Methods: From January 2002 to September 2006, patients with endoscopically proven peptic ulcers/erosions after receiving A + C cotherapy were analyzed. Results: This group consisted of 106 patients (age, 69.3 ± 11.7 years). Ulcers/erosions developed in 27 patients during hospitalization for cardiac events and in 79 patients after hospital discharge. Of 27 patients hospitalized for acute cardiac events, gastrointestinal (GI) bleeding and dyspepsia occurred in 24 and three, respectively. The most common lesion was gastric ulcer. Of 79 discharged patients, GI bleeding and dyspepsia occurred in 64 and 15, respectively. The most common bleeding and dyspeptic lesions were gastric ulcer and gastritis, respectively. Overall, 17 patients underwent endoscopic hemostasis all successfully. A + C cotherapy was continued in 57 patients for a median (interquartile range) of 3.0 (6.2) months. Most were coprescribed a proton pump inhibitor (PPI) (53, 93%). No recurrent GI bleeding was observed. Conclusions: After A + C cotherapy, gastric ulcer or gastritis were the most common endoscopic lesions. The combination of a PPI and endoscopic treatment for ulcer bleeding was highly successful. After patient stabilization, continuation of A + C cotherapy with a PPI appears to be safe. © Springer Japan 2008.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Gastroenterology, 2008, v. 43 n. 9, p. 679-686 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00535-008-2215-4
dc.identifier.doihttp://dx.doi.org/10.1007/s00535-008-2215-4
dc.identifier.epage686
dc.identifier.hkuros158984
dc.identifier.isiWOS:000259371200005
dc.identifier.issn0944-1174
2011 Impact Factor: 4.16
2011 SCImago Journal Rankings: 0.372
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid18807129
dc.identifier.scopuseid_2-s2.0-52749083598
dc.identifier.spage679
dc.identifier.urihttp://hdl.handle.net/10722/77727
dc.identifier.volume43
dc.languageeng
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
dc.publisher.placeJapan
dc.relation.ispartofJournal of Gastroenterology
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - administration & dosage - adverse effects
dc.subject.meshAspirin - administration & dosage - adverse effects
dc.subject.meshCoronary Disease - therapy
dc.subject.meshFemale
dc.subject.meshGastrointestinal Hemorrhage - therapy
dc.subject.meshHemostasis, Endoscopic
dc.subject.meshHospitalization
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPeptic Ulcer - chemically induced - complications - therapy
dc.subject.meshPlatelet Aggregation Inhibitors - therapeutic use
dc.subject.meshStents
dc.subject.meshTiclopidine - administration & dosage - adverse effects - analogs & derivatives
dc.titleManagement and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel
dc.typeArticle
Author Affiliations
  1. Kwong Wah Hospital
  2. The University of Hong Kong
  3. Princess Margaret Hospital Hong Kong
  4. Ruttonjee Hospital Hong Kong