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Article: Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease

TitlePrevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease
Authors
Issue Date2007
PublisherAmerican Medical Association. The Journal's web site is located at http://jama.ama-assn.org/index.dtl
Citation
Journal Of The American Medical Association, 2007, v. 298 n. 12, p. 1412-1419 How to Cite?
AbstractContext: Colorectal neoplasm and coronary artery disease (CAD) share similar risk factors, and their co-occurrence may be associated. Objectives: To investigate the prevalence of colorectal neoplasm in patients with CAD in a cross-sectional study and to identify the predisposing factors for the association of the 2 diseases. Design, Setting, and Participants: Patients in Hong Kong, China, were recruited for screening colonoscopy after undergoing coronary angiography for suspected CAD during November 2004 to June 2006. Presence of CAD (n=206) was defined as at least 50% diameter stenosis in any 1 of the major coronary arteries; otherwise, patients were considered CAD-negative (n=208). An age- and sex-matched control group was recruited from the general population (n=207). Patients were excluded for use of aspirin or statins, personal history of colonic disease, or colonoscopy in the past 10 years. Main Outcome Measures: The prevalence of colorectal neoplasm in CAD-positive, CAD-negative, and general population participants was determined. Bivariate logistic regression was performed to study the association between colorectal neoplasm and CAD and to identify risk factors for the association of the 2 diseases after adjusting for age and sex. Results: The prevalence of colorectal neoplasm in the CAD-positive, CAD-negative, and general population groups was 34.0%, 18.8%, and 20.8% (P<.001 by χ 2 test), prevalence of advanced lesions was 18.4%, 8.7%, and 5.8% (P<.001), and prevalence of cancer was 4.4%, 0.5%, and 1.4% (P=.02), respectively. Fifty percent of the cancers in CAD-positive participants were early stage. After adjusting for age and sex, an association still existed between colorectal neoplasm and presence of CAD (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.25-2.70; P=.002) and between advanced lesions and presence of CAD (OR, 2.51; 95% CI, 1.43-4.35; P=.001). The metabolic syndrome (OR, 5.99; 95% CI, 1.43-27.94; P=.02) and history of smoking (OR, 4.74; 95% CI, 1.38-18.92; P=.02) were independent factors for the association of advanced colonic lesions and CAD. Conclusions: In this study population undergoing coronary angiography, the prevalence of colorectal neoplasm was greater in patients with CAD. The association between the presence of advanced colonic lesions and CAD was stronger in persons with the metabolic syndrome and a history of smoking. ©2007 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77709
ISSN
2015 Impact Factor: 37.684
2015 SCImago Journal Rankings: 6.440
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorMan, HJen_HK
dc.contributor.authorKwok, FLen_HK
dc.contributor.authorMorris, JSen_HK
dc.contributor.authorSiu, DCWen_HK
dc.contributor.authorTong, Ten_HK
dc.contributor.authorFook, HNen_HK
dc.contributor.authorSiu, YWen_HK
dc.contributor.authorWai, MHen_HK
dc.contributor.authorChi, KCen_HK
dc.contributor.authorKam, CLen_HK
dc.contributor.authorTing, KCen_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorWong, Gen_HK
dc.contributor.authorMan, FYen_HK
dc.contributor.authorYuk, KLen_HK
dc.contributor.authorLee, Sen_HK
dc.contributor.authorMing, LSen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorShiu, KLen_HK
dc.date.accessioned2010-09-06T07:34:52Z-
dc.date.available2010-09-06T07:34:52Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of The American Medical Association, 2007, v. 298 n. 12, p. 1412-1419en_HK
dc.identifier.issn0098-7484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77709-
dc.description.abstractContext: Colorectal neoplasm and coronary artery disease (CAD) share similar risk factors, and their co-occurrence may be associated. Objectives: To investigate the prevalence of colorectal neoplasm in patients with CAD in a cross-sectional study and to identify the predisposing factors for the association of the 2 diseases. Design, Setting, and Participants: Patients in Hong Kong, China, were recruited for screening colonoscopy after undergoing coronary angiography for suspected CAD during November 2004 to June 2006. Presence of CAD (n=206) was defined as at least 50% diameter stenosis in any 1 of the major coronary arteries; otherwise, patients were considered CAD-negative (n=208). An age- and sex-matched control group was recruited from the general population (n=207). Patients were excluded for use of aspirin or statins, personal history of colonic disease, or colonoscopy in the past 10 years. Main Outcome Measures: The prevalence of colorectal neoplasm in CAD-positive, CAD-negative, and general population participants was determined. Bivariate logistic regression was performed to study the association between colorectal neoplasm and CAD and to identify risk factors for the association of the 2 diseases after adjusting for age and sex. Results: The prevalence of colorectal neoplasm in the CAD-positive, CAD-negative, and general population groups was 34.0%, 18.8%, and 20.8% (P<.001 by χ 2 test), prevalence of advanced lesions was 18.4%, 8.7%, and 5.8% (P<.001), and prevalence of cancer was 4.4%, 0.5%, and 1.4% (P=.02), respectively. Fifty percent of the cancers in CAD-positive participants were early stage. After adjusting for age and sex, an association still existed between colorectal neoplasm and presence of CAD (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.25-2.70; P=.002) and between advanced lesions and presence of CAD (OR, 2.51; 95% CI, 1.43-4.35; P=.001). The metabolic syndrome (OR, 5.99; 95% CI, 1.43-27.94; P=.02) and history of smoking (OR, 4.74; 95% CI, 1.38-18.92; P=.02) were independent factors for the association of advanced colonic lesions and CAD. Conclusions: In this study population undergoing coronary angiography, the prevalence of colorectal neoplasm was greater in patients with CAD. The association between the presence of advanced colonic lesions and CAD was stronger in persons with the metabolic syndrome and a history of smoking. ©2007 American Medical Association. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://jama.ama-assn.org/index.dtlen_HK
dc.relation.ispartofJournal of the American Medical Associationen_HK
dc.subject.meshAgeden_HK
dc.subject.meshColonoscopyen_HK
dc.subject.meshColorectal Neoplasms - diagnosis - epidemiologyen_HK
dc.subject.meshComorbidityen_HK
dc.subject.meshCoronary Angiographyen_HK
dc.subject.meshCoronary Artery Disease - diagnosis - epidemiologyen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLikelihood Functionsen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMass Screeningen_HK
dc.subject.meshMetabolic Syndrome Xen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSmokingen_HK
dc.titlePrevalence of colorectal neoplasm among patients with newly diagnosed coronary artery diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0098-7484&volume=298 &issue=12&spage=1412&epage=1419&date=2007&atitle=Prevalence+of+Colorectal+Neoplasm+Among+Patients+with+Newly+Diagnosed+Coronary+Artery+Diseaseen_HK
dc.identifier.emailSiu, DCW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authoritySiu, DCW=rp00534en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1001/jama.298.12.1412en_HK
dc.identifier.pmid17895457-
dc.identifier.scopuseid_2-s2.0-34748904899en_HK
dc.identifier.hkuros147595en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34748904899&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume298en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1412en_HK
dc.identifier.epage1419en_HK
dc.identifier.isiWOS:000249698900020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridMan, HJ=22035449700en_HK
dc.identifier.scopusauthoridKwok, FL=16205078500en_HK
dc.identifier.scopusauthoridMorris, JS=7405897451en_HK
dc.identifier.scopusauthoridSiu, DCW=7006550690en_HK
dc.identifier.scopusauthoridTong, T=7102587364en_HK
dc.identifier.scopusauthoridFook, HN=22033946400en_HK
dc.identifier.scopusauthoridSiu, YW=22036403400en_HK
dc.identifier.scopusauthoridWai, MH=16205378100en_HK
dc.identifier.scopusauthoridChi, KC=22033888200en_HK
dc.identifier.scopusauthoridKam, CL=22035036100en_HK
dc.identifier.scopusauthoridTing, KC=14054867100en_HK
dc.identifier.scopusauthoridChan, P=7403497715en_HK
dc.identifier.scopusauthoridWong, G=55040778800en_HK
dc.identifier.scopusauthoridMan, FY=22035435100en_HK
dc.identifier.scopusauthoridYuk, KL=22036697200en_HK
dc.identifier.scopusauthoridLee, S=7601396808en_HK
dc.identifier.scopusauthoridMing, LS=22035713400en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridShiu, KL=36965233000en_HK

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