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Article: Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model

TitlePretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model
Authors
Issue Date2002
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPI
Citation
Journal Of Pineal Research, 2002, v. 32 n. 3, p. 168-172 How to Cite?
AbstractMelatonin is a potent scavenger of free radicals and an indirect antioxidant. Recent studies have shown that melatonin possesses beneficial effects in experimental models of brain trauma and global cerebral ischemia. The effects of pretreatment with melatonin on volume of cerebral infarction were investigated in the present study. Adult male Sprague-Dawley rats were anesthetized with sodium pentobarbital to undergo right-sided endovascular middle cerebral artery occlusion (MCAO) for 3 hr. A single dose of melatonin (1.5, 5, 15, or 50 mg/kg in 1 mL normal saline) or its vehicle was given via an intraperitoneal injection at 0.5 hr before MCAO. Relative infarction volumes on day 3 after MCAO were significantly reduced in the groups treated with melatonin at 5 (mean ± S.E.M., 15.7 ± 2.5%) or 15 (21.4 ± 3.1%) mg/kg but not at 1.5 (30.6 ± 3.5%) or 50 (26.7 ± 2.8%) mg/kg when compared with the vehicle group (33.9 ± 3.5%). There was no significant difference in the arterial blood pressure (BP), heart rate (HR) and relative cerebral blood flow among the experimental groups. These results indicate that pretreatment with melatonin at a dose between 5 and 15 mg/kg protects against focal cerebral ischemia.
Persistent Identifierhttp://hdl.handle.net/10722/77672
ISSN
2015 Impact Factor: 9.314
2015 SCImago Journal Rankings: 2.655
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPei, Zen_HK
dc.contributor.authorPang, SFen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2010-09-06T07:34:27Z-
dc.date.available2010-09-06T07:34:27Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Pineal Research, 2002, v. 32 n. 3, p. 168-172en_HK
dc.identifier.issn0742-3098en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77672-
dc.description.abstractMelatonin is a potent scavenger of free radicals and an indirect antioxidant. Recent studies have shown that melatonin possesses beneficial effects in experimental models of brain trauma and global cerebral ischemia. The effects of pretreatment with melatonin on volume of cerebral infarction were investigated in the present study. Adult male Sprague-Dawley rats were anesthetized with sodium pentobarbital to undergo right-sided endovascular middle cerebral artery occlusion (MCAO) for 3 hr. A single dose of melatonin (1.5, 5, 15, or 50 mg/kg in 1 mL normal saline) or its vehicle was given via an intraperitoneal injection at 0.5 hr before MCAO. Relative infarction volumes on day 3 after MCAO were significantly reduced in the groups treated with melatonin at 5 (mean ± S.E.M., 15.7 ± 2.5%) or 15 (21.4 ± 3.1%) mg/kg but not at 1.5 (30.6 ± 3.5%) or 50 (26.7 ± 2.8%) mg/kg when compared with the vehicle group (33.9 ± 3.5%). There was no significant difference in the arterial blood pressure (BP), heart rate (HR) and relative cerebral blood flow among the experimental groups. These results indicate that pretreatment with melatonin at a dose between 5 and 15 mg/kg protects against focal cerebral ischemia.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPIen_HK
dc.relation.ispartofJournal of Pineal Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - blood supply - drug effectsen_HK
dc.subject.meshCerebrovascular Circulation - drug effectsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshHemodynamics - drug effectsen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshInfarction, Middle Cerebral Artery - drug therapy - pathology - prevention & controlen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMelatonin - administration & dosageen_HK
dc.subject.meshNeuroprotective Agents - administration & dosageen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titlePretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0742-3098&volume=32&spage=168&epage=172&date=2002&atitle=Pretreatment+with+melatonin+reduces+volume+of+cerebral+infarction+in+a+rat+middle+cerebral+artery+occlusion+stroke+modelen_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1600-079x.2002.1o847.xen_HK
dc.identifier.pmid12074100-
dc.identifier.scopuseid_2-s2.0-0036229548en_HK
dc.identifier.hkuros87776en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036229548&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue3en_HK
dc.identifier.spage168en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:000175102200006-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridPei, Z=23051646800en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK

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