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Article: Bronchodilator responses to salbutamol using diskhaler versus metered-dose inhaler

TitleBronchodilator responses to salbutamol using diskhaler versus metered-dose inhaler
Authors
Issue Date1998
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02770903.asp
Citation
Journal Of Asthma, 1998, v. 35 n. 6, p. 505-511 How to Cite?
AbstractIn adults inhaling salbutamol via metered-dose inhalers (MDIs) 200 μg doses are recommended, but with diskhalers the manufacturer advocates 400 rather than 200 μg doses. To assess this advice, a partially double-blind, placebo-controlled salbutamol dose response, crossover study (also incorporating MDI doses) was conducted in 12 mild/moderate asthmatics. After active treatment, mean peak expiratory flow rate (PEFR) increments yielded no clinically or statistically significant differences; compared to placebo, respective median differences in PEFR increments (95% Cls) were 10 (-10, 50), 20 (0, 50), and 15 (0, 30) following 400 and 200 μg via diskhalers and 200 μg via MDIs. Diskhalers are a suitable alternative for patients with poor MDI technique, but the use of 400 rather than 200 μg salbutamol doses is not supported by evidence.
Persistent Identifierhttp://hdl.handle.net/10722/77645
ISSN
2015 Impact Factor: 1.854
2015 SCImago Journal Rankings: 0.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKou, Men_HK
dc.contributor.authorKumana, CRen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLauder, IJen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorChan, JCKen_HK
dc.date.accessioned2010-09-06T07:34:10Z-
dc.date.available2010-09-06T07:34:10Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Asthma, 1998, v. 35 n. 6, p. 505-511en_HK
dc.identifier.issn0277-0903en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77645-
dc.description.abstractIn adults inhaling salbutamol via metered-dose inhalers (MDIs) 200 μg doses are recommended, but with diskhalers the manufacturer advocates 400 rather than 200 μg doses. To assess this advice, a partially double-blind, placebo-controlled salbutamol dose response, crossover study (also incorporating MDI doses) was conducted in 12 mild/moderate asthmatics. After active treatment, mean peak expiratory flow rate (PEFR) increments yielded no clinically or statistically significant differences; compared to placebo, respective median differences in PEFR increments (95% Cls) were 10 (-10, 50), 20 (0, 50), and 15 (0, 30) following 400 and 200 μg via diskhalers and 200 μg via MDIs. Diskhalers are a suitable alternative for patients with poor MDI technique, but the use of 400 rather than 200 μg salbutamol doses is not supported by evidence.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02770903.aspen_HK
dc.relation.ispartofJournal of Asthmaen_HK
dc.rightsJournal of Asthma. Copyright © Informa Healthcare.en_HK
dc.subject.meshAdrenergic beta-Agonists - administration & dosageen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAlbuterol - administration & dosageen_HK
dc.subject.meshAsthma - drug therapy - physiopathologyen_HK
dc.subject.meshBronchodilator Agents - administration & dosageen_HK
dc.subject.meshCross-Over Studiesen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshEquipment Designen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNebulizers and Vaporizersen_HK
dc.subject.meshPeak Expiratory Flow Rateen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.titleBronchodilator responses to salbutamol using diskhaler versus metered-dose inhaleren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0277-0903&volume=35&spage=505&epage=511&date=1998&atitle=Bronchodilator+responses+to+salbutamol+using+diskhaler+versus+metered-dose+inhaleren_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9751068-
dc.identifier.scopuseid_2-s2.0-0031703607en_HK
dc.identifier.hkuros39198en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031703607&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue6en_HK
dc.identifier.spage505en_HK
dc.identifier.epage511en_HK
dc.identifier.isiWOS:000075978800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKou, M=7004545950en_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLauder, IJ=35564928000en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridChan, JCK=23090202000en_HK

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