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Article: A Magnetic Resonance Imaging Study of Iron Overload in Hemopoietic Stem Cell Transplant Recipients With Increased Ferritin Levels

TitleA Magnetic Resonance Imaging Study of Iron Overload in Hemopoietic Stem Cell Transplant Recipients With Increased Ferritin Levels
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/transproceed
Citation
Transplantation Proceedings, 2007, v. 39 n. 10, p. 3369-3374 How to Cite?
AbstractWe performed a study of magnetic resonance imaging (MRI) assessment of hemosiderosis in the heart (T2/T2*), liver (T2*), pancreas (T2*), and pituitary gland (T2/T2*/SIR) in 20 hemopoietic stem cell transplant (HSCT) recipients (median peak ferritin levels 7615 pmol/L, range 3411 to 33000 pmol/L). MRI reading was abnormal in the heart (5%), liver (85%), pancreas (40%), and pituitary gland (55%). The heart T2 correlated with peak ferritin levels (P = .024), while the liver T2* correlated with current ferritin (P = .038) values only. Pancreatic T2* values correlated with pituitary T2 and signal intensity ratio values. The ejection fraction was abnormal in 10% of cases and did not correlate with ferritin level or heart T2. The peak liver enzymes correlated with peak ferritin (P = .025), but the current liver enzymes were mostly normal. Pancreatic assessments (fasting glucose, insulin, beta cell function, insulin reserve, and C-peptide) and pituitary growth hormone axis assessments (growth hormone, insulin growth factor-1, and insulin growth factor binding protein-3) were abnormal in 40% to 70% of cases. They were unrelated to pancreas or pituitary MRI values. Interestingly, endocrine assessments correlated with heart T2 values and peak (but not current) ferritin levels. We concluded that iron overload may contribute to organ damage after HSCT, and MRI assessment may be useful in its detection and treatment monitoring. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77610
ISSN
2015 Impact Factor: 0.867
2015 SCImago Journal Rankings: 0.455
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorChu, WCen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, WKen_HK
dc.contributor.authorPennell, DJen_HK
dc.contributor.authorLie, AKen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:33:46Z-
dc.date.available2010-09-06T07:33:46Z-
dc.date.issued2007en_HK
dc.identifier.citationTransplantation Proceedings, 2007, v. 39 n. 10, p. 3369-3374en_HK
dc.identifier.issn0041-1345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77610-
dc.description.abstractWe performed a study of magnetic resonance imaging (MRI) assessment of hemosiderosis in the heart (T2/T2*), liver (T2*), pancreas (T2*), and pituitary gland (T2/T2*/SIR) in 20 hemopoietic stem cell transplant (HSCT) recipients (median peak ferritin levels 7615 pmol/L, range 3411 to 33000 pmol/L). MRI reading was abnormal in the heart (5%), liver (85%), pancreas (40%), and pituitary gland (55%). The heart T2 correlated with peak ferritin levels (P = .024), while the liver T2* correlated with current ferritin (P = .038) values only. Pancreatic T2* values correlated with pituitary T2 and signal intensity ratio values. The ejection fraction was abnormal in 10% of cases and did not correlate with ferritin level or heart T2. The peak liver enzymes correlated with peak ferritin (P = .025), but the current liver enzymes were mostly normal. Pancreatic assessments (fasting glucose, insulin, beta cell function, insulin reserve, and C-peptide) and pituitary growth hormone axis assessments (growth hormone, insulin growth factor-1, and insulin growth factor binding protein-3) were abnormal in 40% to 70% of cases. They were unrelated to pancreas or pituitary MRI values. Interestingly, endocrine assessments correlated with heart T2 values and peak (but not current) ferritin levels. We concluded that iron overload may contribute to organ damage after HSCT, and MRI assessment may be useful in its detection and treatment monitoring. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/transproceeden_HK
dc.relation.ispartofTransplantation Proceedingsen_HK
dc.rightsTransplantation Proceedings. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnemia, Aplastic - pathology - therapyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFerritins - metabolismen_HK
dc.subject.meshHeart Diseases - pathology - therapyen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effectsen_HK
dc.subject.meshHemosiderosis - pathology - therapyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIron Overload - etiologyen_HK
dc.subject.meshLeukemia - pathology - therapyen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrimary Myelofibrosis - pathology - therapyen_HK
dc.subject.meshTransplantation, Homologous - physiologyen_HK
dc.titleA Magnetic Resonance Imaging Study of Iron Overload in Hemopoietic Stem Cell Transplant Recipients With Increased Ferritin Levelsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-1345&volume=39&issue=10&spage=3369&epage=3374 &date=2007&atitle=A+Magnetic+Resonance+Imaging+Study+of+Iron+Overload+in+Hemopoietic+Stem+Cell+Transplant+Recipients+With+Increased+Ferritin+Levelsen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.transproceed.2007.09.027en_HK
dc.identifier.pmid18089387-
dc.identifier.scopuseid_2-s2.0-37049010103en_HK
dc.identifier.hkuros145668en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37049010103&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue10en_HK
dc.identifier.spage3369en_HK
dc.identifier.epage3374en_HK
dc.identifier.isiWOS:000252037900090-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLam, WM=13410486800en_HK
dc.identifier.scopusauthoridChu, WC=7402227871en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, WK=14055124500en_HK
dc.identifier.scopusauthoridPennell, DJ=7103221771en_HK
dc.identifier.scopusauthoridLie, AK=7004510870en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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