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Article: The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer

TitleThe clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
Authors
KeywordsAutofluorescence bronchoscopy
Clinical tool
Lung cancer
Pre-invasive lesion
Issue Date2006
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2006, v. 28 n. 5, p. 915-919 How to Cite?
Abstract
The aim of this study was to evaluate the role of autofluorescence bronchoscopy (AFB) in the routine work-up of lung cancer. Consecutive patients with atypical or suspicious cells in sputum or bronchial aspirate, no localising abnormality on chest radiography and nondiagnostic white-light bronchoscopic (WLB) results were recruited. WLB and AFB were performed sequentially during the same session. All abnormal areas detected by WLB, AFB or both were sampled and the biopsy specimens sent for histological examination. Sixty-two patients were recruited within the 32-month study period. Seventeen had no endobronchial lesion detected. Among the 45 patients with endobronchial lesions, 37 had lesions with a histopathological grade of mild dysplasia or less; of the eight patients who had a lesion with a histological grade of moderate dysplasia or worse, five were found to have lung cancer, two invasive lung cancer and three an intra-epithelial neoplasm (severe dysplasia). Lesions showing moderate dysplasia or worse were more commonly found in patients with suspicious cells than in those with atypical cells on sputum examination. AFB was more sensitive than WLB (91 versus 58%) at detecting these lesions, but less specific (26 versus 50%). A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology. Copyright © ERS Journals Ltd 2006.
Persistent Identifierhttp://hdl.handle.net/10722/77606
ISSN
2013 Impact Factor: 7.125
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, Ben_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorFung, SLen_HK
dc.contributor.authorLam, DCLen_HK
dc.contributor.authorWong, PCen_HK
dc.contributor.authorMok, TYWen_HK
dc.contributor.authorLam, FMen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-06T07:33:43Z-
dc.date.available2010-09-06T07:33:43Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Respiratory Journal, 2006, v. 28 n. 5, p. 915-919en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77606-
dc.description.abstractThe aim of this study was to evaluate the role of autofluorescence bronchoscopy (AFB) in the routine work-up of lung cancer. Consecutive patients with atypical or suspicious cells in sputum or bronchial aspirate, no localising abnormality on chest radiography and nondiagnostic white-light bronchoscopic (WLB) results were recruited. WLB and AFB were performed sequentially during the same session. All abnormal areas detected by WLB, AFB or both were sampled and the biopsy specimens sent for histological examination. Sixty-two patients were recruited within the 32-month study period. Seventeen had no endobronchial lesion detected. Among the 45 patients with endobronchial lesions, 37 had lesions with a histopathological grade of mild dysplasia or less; of the eight patients who had a lesion with a histological grade of moderate dysplasia or worse, five were found to have lung cancer, two invasive lung cancer and three an intra-epithelial neoplasm (severe dysplasia). Lesions showing moderate dysplasia or worse were more commonly found in patients with suspicious cells than in those with atypical cells on sputum examination. AFB was more sensitive than WLB (91 versus 58%) at detecting these lesions, but less specific (26 versus 50%). A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology. Copyright © ERS Journals Ltd 2006.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectAutofluorescence bronchoscopyen_HK
dc.subjectClinical toolen_HK
dc.subjectLung canceren_HK
dc.subjectPre-invasive lesionen_HK
dc.subject.meshBronchi - pathology-
dc.subject.meshBronchial Neoplasms - diagnosis - pathology-
dc.subject.meshBronchoscopy - methods-
dc.subject.meshFluorescence-
dc.subject.meshLung Neoplasms - diagnosis-
dc.titleThe clinical value of autofluorescence bronchoscopy for the diagnosis of lung canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=28&issue=5&spage=915&epage=919&date=2006&atitle=The+clinical+value+of+autofluorescence+bronchoscopy+for+the+diagnosis+of+lung+canceren_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.emailLam, DCL:lamcl@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1183/09031936.06.00131405en_HK
dc.identifier.pmid16870657en_HK
dc.identifier.scopuseid_2-s2.0-33847379780en_HK
dc.identifier.hkuros134827en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847379780&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue5en_HK
dc.identifier.spage915en_HK
dc.identifier.epage919en_HK
dc.identifier.isiWOS:000241994200007-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridFung, SL=36985944500en_HK
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridWong, PC=7403979916en_HK
dc.identifier.scopusauthoridMok, TYW=8706357200en_HK
dc.identifier.scopusauthoridLam, FM=7102075928en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridOoi, CGC=7007084909en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK

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