Article: The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer

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TitleThe clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
AuthorsLam, B1
Wong, MP1
Fung, SL2
Lam, DCL1
Wong, PC2
Mok, TYW3
Lam, FM2
Ip, MSM1
Ooi, CGC1
Lam, WK1
KeywordsAutofluorescence bronchoscopy
Clinical tool
Lung cancer
Pre-invasive lesion
Issue Date2006
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
CitationEuropean Respiratory Journal, 2006, v. 28 n. 5, p. 915-919 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.06.00131405
AbstractThe aim of this study was to evaluate the role of autofluorescence bronchoscopy (AFB) in the routine work-up of lung cancer. Consecutive patients with atypical or suspicious cells in sputum or bronchial aspirate, no localising abnormality on chest radiography and nondiagnostic white-light bronchoscopic (WLB) results were recruited. WLB and AFB were performed sequentially during the same session. All abnormal areas detected by WLB, AFB or both were sampled and the biopsy specimens sent for histological examination. Sixty-two patients were recruited within the 32-month study period. Seventeen had no endobronchial lesion detected. Among the 45 patients with endobronchial lesions, 37 had lesions with a histopathological grade of mild dysplasia or less; of the eight patients who had a lesion with a histological grade of moderate dysplasia or worse, five were found to have lung cancer, two invasive lung cancer and three an intra-epithelial neoplasm (severe dysplasia). Lesions showing moderate dysplasia or worse were more commonly found in patients with suspicious cells than in those with atypical cells on sputum examination. AFB was more sensitive than WLB (91 versus 58%) at detecting these lesions, but less specific (26 versus 50%). A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology. Copyright © ERS Journals Ltd 2006.
ISSN0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
DOIhttp://dx.doi.org/10.1183/09031936.06.00131405
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLam, B
dc.contributor.authorWong, MP
dc.contributor.authorFung, SL
dc.contributor.authorLam, DCL
dc.contributor.authorWong, PC
dc.contributor.authorMok, TYW
dc.contributor.authorLam, FM
dc.contributor.authorIp, MSM
dc.contributor.authorOoi, CGC
dc.contributor.authorLam, WK
dc.date.accessioned2010-09-06T07:33:43Z
dc.date.available2010-09-06T07:33:43Z
dc.date.issued2006
dc.description.abstractThe aim of this study was to evaluate the role of autofluorescence bronchoscopy (AFB) in the routine work-up of lung cancer. Consecutive patients with atypical or suspicious cells in sputum or bronchial aspirate, no localising abnormality on chest radiography and nondiagnostic white-light bronchoscopic (WLB) results were recruited. WLB and AFB were performed sequentially during the same session. All abnormal areas detected by WLB, AFB or both were sampled and the biopsy specimens sent for histological examination. Sixty-two patients were recruited within the 32-month study period. Seventeen had no endobronchial lesion detected. Among the 45 patients with endobronchial lesions, 37 had lesions with a histopathological grade of mild dysplasia or less; of the eight patients who had a lesion with a histological grade of moderate dysplasia or worse, five were found to have lung cancer, two invasive lung cancer and three an intra-epithelial neoplasm (severe dysplasia). Lesions showing moderate dysplasia or worse were more commonly found in patients with suspicious cells than in those with atypical cells on sputum examination. AFB was more sensitive than WLB (91 versus 58%) at detecting these lesions, but less specific (26 versus 50%). A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology. Copyright © ERS Journals Ltd 2006.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationEuropean Respiratory Journal, 2006, v. 28 n. 5, p. 915-919 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.06.00131405
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.06.00131405
dc.identifier.epage919
dc.identifier.hkuros134827
dc.identifier.isiWOS:000241994200007
dc.identifier.issn0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid16870657
dc.identifier.scopuseid_2-s2.0-33847379780
dc.identifier.spage915
dc.identifier.urihttp://hdl.handle.net/10722/77606
dc.identifier.volume28
dc.languageeng
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
dc.publisher.placeSwitzerland
dc.relation.ispartofEuropean Respiratory Journal
dc.relation.referencesReferences in Scopus
dc.subject.meshBronchi - pathology
dc.subject.meshBronchial Neoplasms - diagnosis - pathology
dc.subject.meshBronchoscopy - methods
dc.subject.meshFluorescence
dc.subject.meshLung Neoplasms - diagnosis
dc.subjectAutofluorescence bronchoscopy
dc.subjectClinical tool
dc.subjectLung cancer
dc.subjectPre-invasive lesion
dc.titleThe clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Grantham Hospital Hong Kong
  3. Kowloon Hospital