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Article: The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
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TitleThe clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
 
AuthorsLam, B1
Wong, MP1
Fung, SL2
Lam, DCL1
Wong, PC2
Mok, TYW3
Lam, FM2
Ip, MSM1
Ooi, CGC1
Lam, WK1
 
KeywordsAutofluorescence bronchoscopy
Clinical tool
Lung cancer
Pre-invasive lesion
 
Issue Date2006
 
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
 
CitationEuropean Respiratory Journal, 2006, v. 28 n. 5, p. 915-919 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.06.00131405
 
AbstractThe aim of this study was to evaluate the role of autofluorescence bronchoscopy (AFB) in the routine work-up of lung cancer. Consecutive patients with atypical or suspicious cells in sputum or bronchial aspirate, no localising abnormality on chest radiography and nondiagnostic white-light bronchoscopic (WLB) results were recruited. WLB and AFB were performed sequentially during the same session. All abnormal areas detected by WLB, AFB or both were sampled and the biopsy specimens sent for histological examination. Sixty-two patients were recruited within the 32-month study period. Seventeen had no endobronchial lesion detected. Among the 45 patients with endobronchial lesions, 37 had lesions with a histopathological grade of mild dysplasia or less; of the eight patients who had a lesion with a histological grade of moderate dysplasia or worse, five were found to have lung cancer, two invasive lung cancer and three an intra-epithelial neoplasm (severe dysplasia). Lesions showing moderate dysplasia or worse were more commonly found in patients with suspicious cells than in those with atypical cells on sputum examination. AFB was more sensitive than WLB (91 versus 58%) at detecting these lesions, but less specific (26 versus 50%). A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology. Copyright © ERS Journals Ltd 2006.
 
ISSN0903-1936
2013 Impact Factor: 7.125
 
DOIhttp://dx.doi.org/10.1183/09031936.06.00131405
 
ISI Accession Number IDWOS:000241994200007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLam, B
 
dc.contributor.authorWong, MP
 
dc.contributor.authorFung, SL
 
dc.contributor.authorLam, DCL
 
dc.contributor.authorWong, PC
 
dc.contributor.authorMok, TYW
 
dc.contributor.authorLam, FM
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorOoi, CGC
 
dc.contributor.authorLam, WK
 
dc.date.accessioned2010-09-06T07:33:43Z
 
dc.date.available2010-09-06T07:33:43Z
 
dc.date.issued2006
 
dc.description.abstractThe aim of this study was to evaluate the role of autofluorescence bronchoscopy (AFB) in the routine work-up of lung cancer. Consecutive patients with atypical or suspicious cells in sputum or bronchial aspirate, no localising abnormality on chest radiography and nondiagnostic white-light bronchoscopic (WLB) results were recruited. WLB and AFB were performed sequentially during the same session. All abnormal areas detected by WLB, AFB or both were sampled and the biopsy specimens sent for histological examination. Sixty-two patients were recruited within the 32-month study period. Seventeen had no endobronchial lesion detected. Among the 45 patients with endobronchial lesions, 37 had lesions with a histopathological grade of mild dysplasia or less; of the eight patients who had a lesion with a histological grade of moderate dysplasia or worse, five were found to have lung cancer, two invasive lung cancer and three an intra-epithelial neoplasm (severe dysplasia). Lesions showing moderate dysplasia or worse were more commonly found in patients with suspicious cells than in those with atypical cells on sputum examination. AFB was more sensitive than WLB (91 versus 58%) at detecting these lesions, but less specific (26 versus 50%). A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology. Copyright © ERS Journals Ltd 2006.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationEuropean Respiratory Journal, 2006, v. 28 n. 5, p. 915-919 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.06.00131405
 
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.06.00131405
 
dc.identifier.epage919
 
dc.identifier.hkuros134827
 
dc.identifier.isiWOS:000241994200007
 
dc.identifier.issn0903-1936
2013 Impact Factor: 7.125
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid16870657
 
dc.identifier.scopuseid_2-s2.0-33847379780
 
dc.identifier.spage915
 
dc.identifier.urihttp://hdl.handle.net/10722/77606
 
dc.identifier.volume28
 
dc.languageeng
 
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofEuropean Respiratory Journal
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBronchi - pathology
 
dc.subject.meshBronchial Neoplasms - diagnosis - pathology
 
dc.subject.meshBronchoscopy - methods
 
dc.subject.meshFluorescence
 
dc.subject.meshLung Neoplasms - diagnosis
 
dc.subjectAutofluorescence bronchoscopy
 
dc.subjectClinical tool
 
dc.subjectLung cancer
 
dc.subjectPre-invasive lesion
 
dc.titleThe clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Grantham Hospital Hong Kong
  3. Kowloon Hospital