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Article: Splanchnic erythrocyte content decreases during hemodialysis: A new compensatory mechanism for hypovolemia

TitleSplanchnic erythrocyte content decreases during hemodialysis: A new compensatory mechanism for hypovolemia
Authors
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
Citation
Kidney International, 1997, v. 51 n. 6, p. 1986-1990 How to Cite?
AbstractSplanchnic and splenic erythrocyte volumes decrease during postural changes and exercise to help maintain central blood volume and cardiac output. The contribution of this compensatory mechanism to hemodynamic stability during dialysis has not been studied, however. In 8 ESRD patients, age 51.0 ± 4.5 years old, we measured changes in the splanchnic/splenic erythrocyte volume during dialysis by tagging the patients' erythrocytes with technetium and following abdominal radioactivity over time. Splanchnic radioactivity decreased to 90.2 ± 3.8% (mean ± SEM) of the baseline value after 2 hr of accelerated fluid removal (3.7 ± 0.4 liters) during dialysis (DUF), while it remained relatively unchanged after two hours of dialysis without fluid removal (DD) [106.5 ± 2.3%, P (DUF vs. DD) = 0.03]. Splenic radioactivity decreased to 89.2 ± 5.0% of the initial value during DUF versus 103 ± 3.8% during DD, but the decrease was noted only during the last 30 minutes of DUF and did not attain statistical significance. Autonomic nervous system integrity was measured by the spontaneous variation of the R-R interval during deep respiration (E/I ratio) and by the Valsalva ratio. The mean E/I and Valsalva ratios in the eight patients were 1.13 ± 0.03 (± SEM) and 1.42 ± 0.1 respectively, suggesting reasonably adequate autonomic nervous system functioning. The results suggest that contraction of the splanchnic, and possibly the splenic, vascular beds occurs during fluid removal associated with hemodialysis. The resultant addition of erythrocytes to the circulation may help maintain central blood volume and cardiac output.
Persistent Identifierhttp://hdl.handle.net/10722/77599
ISSN
2015 Impact Factor: 7.683
2015 SCImago Journal Rankings: 3.181
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, AWen_HK
dc.contributor.authorNawab, ZMen_HK
dc.contributor.authorBarnes, WEen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorIng, TSen_HK
dc.contributor.authorDaugirdas, JTen_HK
dc.date.accessioned2010-09-06T07:33:39Z-
dc.date.available2010-09-06T07:33:39Z-
dc.date.issued1997en_HK
dc.identifier.citationKidney International, 1997, v. 51 n. 6, p. 1986-1990en_HK
dc.identifier.issn0085-2538en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77599-
dc.description.abstractSplanchnic and splenic erythrocyte volumes decrease during postural changes and exercise to help maintain central blood volume and cardiac output. The contribution of this compensatory mechanism to hemodynamic stability during dialysis has not been studied, however. In 8 ESRD patients, age 51.0 ± 4.5 years old, we measured changes in the splanchnic/splenic erythrocyte volume during dialysis by tagging the patients' erythrocytes with technetium and following abdominal radioactivity over time. Splanchnic radioactivity decreased to 90.2 ± 3.8% (mean ± SEM) of the baseline value after 2 hr of accelerated fluid removal (3.7 ± 0.4 liters) during dialysis (DUF), while it remained relatively unchanged after two hours of dialysis without fluid removal (DD) [106.5 ± 2.3%, P (DUF vs. DD) = 0.03]. Splenic radioactivity decreased to 89.2 ± 5.0% of the initial value during DUF versus 103 ± 3.8% during DD, but the decrease was noted only during the last 30 minutes of DUF and did not attain statistical significance. Autonomic nervous system integrity was measured by the spontaneous variation of the R-R interval during deep respiration (E/I ratio) and by the Valsalva ratio. The mean E/I and Valsalva ratios in the eight patients were 1.13 ± 0.03 (± SEM) and 1.42 ± 0.1 respectively, suggesting reasonably adequate autonomic nervous system functioning. The results suggest that contraction of the splanchnic, and possibly the splenic, vascular beds occurs during fluid removal associated with hemodialysis. The resultant addition of erythrocytes to the circulation may help maintain central blood volume and cardiac output.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.htmlen_HK
dc.relation.ispartofKidney Internationalen_HK
dc.titleSplanchnic erythrocyte content decreases during hemodialysis: A new compensatory mechanism for hypovolemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0085-2538&volume=51&spage=1986&epage=1990&date=1997&atitle=Splanchnic+erythrocyte+content+decreases+during+hemodialysis.+A+new+compensatory+mechanism+for+hypovolemiaen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9186892-
dc.identifier.scopuseid_2-s2.0-0030979325en_HK
dc.identifier.hkuros41374en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030979325&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1986en_HK
dc.identifier.epage1990en_HK
dc.identifier.isiWOS:A1997XD05700039-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, AW=7401478900en_HK
dc.identifier.scopusauthoridNawab, ZM=6701341529en_HK
dc.identifier.scopusauthoridBarnes, WE=35875003400en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridIng, TS=7102899357en_HK
dc.identifier.scopusauthoridDaugirdas, JT=7006219650en_HK

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