Article: Symptom resolution does not predict healing of erosive oesophagitis in Chinese

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TitleSymptom resolution does not predict healing of erosive oesophagitis in Chinese
AuthorsCheung, TK
Wong, WM
Wong, NYH
Chan, CK
Fung, J
Yuen, MF
Chan, AOO
Tong, TSM
Wong, BCY1
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
CitationDigestion, 2007, v. 75 n. 2-3, p. 128-134 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000106453
AbstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.
ISSN0012-2823
2011 Impact Factor: 2.046
2011 SCImago Journal Rankings: 0.157
DOIhttp://dx.doi.org/10.1159/000106453
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, TK
dc.contributor.authorWong, WM
dc.contributor.authorWong, NYH
dc.contributor.authorChan, CK
dc.contributor.authorFung, J
dc.contributor.authorYuen, MF
dc.contributor.authorChan, AOO
dc.contributor.authorTong, TSM
dc.contributor.authorWong, BCY
dc.date.accessioned2010-09-06T07:33:30Z
dc.date.available2010-09-06T07:33:30Z
dc.date.issued2007
dc.description.abstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDigestion, 2007, v. 75 n. 2-3, p. 128-134 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000106453
dc.identifier.doihttp://dx.doi.org/10.1159/000106453
dc.identifier.epage134
dc.identifier.hkuros134098
dc.identifier.isiWOS:000249383500018
dc.identifier.issn0012-2823
2011 Impact Factor: 2.046
2011 SCImago Journal Rankings: 0.157
dc.identifier.issue2-3
dc.identifier.openurl
dc.identifier.pmid17671381
dc.identifier.scopuseid_2-s2.0-34548303549
dc.identifier.spage128
dc.identifier.urihttp://hdl.handle.net/10722/77586
dc.identifier.volume75
dc.languageeng
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
dc.publisher.placeSwitzerland
dc.relation.ispartofDigestion
dc.relation.referencesReferences in Scopus
dc.rightsDigestion. Copyright © S Karger AG.
dc.subject.meshAnti-Ulcer Agents - therapeutic use
dc.subject.meshChi-Square Distribution
dc.subject.meshChina
dc.subject.meshEsophagitis - drug therapy - ethnology
dc.subject.meshEsophagoscopy
dc.subject.meshFemale
dc.subject.meshGastric Acidity Determination
dc.subject.meshHumans
dc.subject.meshHydrogen-Ion Concentration
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshManometry
dc.subject.meshMiddle Aged
dc.subject.meshOmeprazole - therapeutic use
dc.subject.meshQuestionnaires
dc.subject.meshRisk Factors
dc.subject.meshSeverity of Illness Index
dc.subject.meshTreatment Outcome
dc.titleSymptom resolution does not predict healing of erosive oesophagitis in Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong