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Article: Symptom resolution does not predict healing of erosive oesophagitis in Chinese
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TitleSymptom resolution does not predict healing of erosive oesophagitis in Chinese
 
AuthorsCheung, TK
Wong, WM
Wong, NYH
Chan, CK
Fung, J
Yuen, MF
Chan, AOO
Tong, TSM
Wong, BCY1
 
Issue Date2007
 
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
 
CitationDigestion, 2007, v. 75 n. 2-3, p. 128-134 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000106453
 
AbstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.
 
ISSN0012-2823
2012 Impact Factor: 1.94
2012 SCImago Journal Rankings: 0.833
 
DOIhttp://dx.doi.org/10.1159/000106453
 
ISI Accession Number IDWOS:000249383500018
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, TK
 
dc.contributor.authorWong, WM
 
dc.contributor.authorWong, NYH
 
dc.contributor.authorChan, CK
 
dc.contributor.authorFung, J
 
dc.contributor.authorYuen, MF
 
dc.contributor.authorChan, AOO
 
dc.contributor.authorTong, TSM
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2010-09-06T07:33:30Z
 
dc.date.available2010-09-06T07:33:30Z
 
dc.date.issued2007
 
dc.description.abstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDigestion, 2007, v. 75 n. 2-3, p. 128-134 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000106453
 
dc.identifier.doihttp://dx.doi.org/10.1159/000106453
 
dc.identifier.epage134
 
dc.identifier.hkuros134098
 
dc.identifier.isiWOS:000249383500018
 
dc.identifier.issn0012-2823
2012 Impact Factor: 1.94
2012 SCImago Journal Rankings: 0.833
 
dc.identifier.issue2-3
 
dc.identifier.openurl
 
dc.identifier.pmid17671381
 
dc.identifier.scopuseid_2-s2.0-34548303549
 
dc.identifier.spage128
 
dc.identifier.urihttp://hdl.handle.net/10722/77586
 
dc.identifier.volume75
 
dc.languageeng
 
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofDigestion
 
dc.relation.referencesReferences in Scopus
 
dc.rightsDigestion. Copyright © S Karger AG.
 
dc.subject.meshAnti-Ulcer Agents - therapeutic use
 
dc.subject.meshChi-Square Distribution
 
dc.subject.meshChina
 
dc.subject.meshEsophagitis - drug therapy - ethnology
 
dc.subject.meshEsophagoscopy
 
dc.subject.meshFemale
 
dc.subject.meshGastric Acidity Determination
 
dc.subject.meshHumans
 
dc.subject.meshHydrogen-Ion Concentration
 
dc.subject.meshLogistic Models
 
dc.subject.meshMale
 
dc.subject.meshManometry
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOmeprazole - therapeutic use
 
dc.subject.meshQuestionnaires
 
dc.subject.meshRisk Factors
 
dc.subject.meshSeverity of Illness Index
 
dc.subject.meshTreatment Outcome
 
dc.titleSymptom resolution does not predict healing of erosive oesophagitis in Chinese
 
dc.typeArticle
 
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<contributor.author>Chan, CK</contributor.author>
<contributor.author>Fung, J</contributor.author>
<contributor.author>Yuen, MF</contributor.author>
<contributor.author>Chan, AOO</contributor.author>
<contributor.author>Tong, TSM</contributor.author>
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Author Affiliations
  1. The University of Hong Kong