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Article: Symptom resolution does not predict healing of erosive oesophagitis in Chinese

TitleSymptom resolution does not predict healing of erosive oesophagitis in Chinese
Authors
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 2007, v. 75 n. 2-3, p. 128-134 How to Cite?
AbstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/77586
ISSN
2014 Impact Factor: 2.097
2014 SCImago Journal Rankings: 0.800
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWong, NYHen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorTong, TSMen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:33:30Z-
dc.date.available2010-09-06T07:33:30Z-
dc.date.issued2007en_HK
dc.identifier.citationDigestion, 2007, v. 75 n. 2-3, p. 128-134en_HK
dc.identifier.issn0012-2823en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77586-
dc.description.abstractBackground: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese. Copyright © 2007 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_HK
dc.relation.ispartofDigestionen_HK
dc.rightsDigestion. Copyright © S Karger AG.en_HK
dc.subject.meshAnti-Ulcer Agents - therapeutic useen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshChinaen_HK
dc.subject.meshEsophagitis - drug therapy - ethnologyen_HK
dc.subject.meshEsophagoscopyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastric Acidity Determinationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydrogen-Ion Concentrationen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshManometryen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOmeprazole - therapeutic useen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleSymptom resolution does not predict healing of erosive oesophagitis in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-2823&volume=75&issue=2-3&spage=128&epage=134&date=2007&atitle=Symptom+Resolution+Does+Not+Predict+Healing+of+Erosive+Oesophagitis+in+Chineseen_HK
dc.identifier.emailFung, J:jfung@sicklehut.comen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000106453en_HK
dc.identifier.pmid17671381en_HK
dc.identifier.scopuseid_2-s2.0-34548303549en_HK
dc.identifier.hkuros134098en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548303549&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage128en_HK
dc.identifier.epage134en_HK
dc.identifier.isiWOS:000249383500018-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridCheung, TK=7103334158en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridWong, NYH=7202836655en_HK
dc.identifier.scopusauthoridChan, CK=7404813960en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridTong, TSM=7102587364en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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