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Article: Clinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura in adult Chinese patients: An analysis of 220 cases

TitleClinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura in adult Chinese patients: An analysis of 220 cases
Authors
Issue Date2001
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2001, v. 80 n. 7, p. 384-386 How to Cite?
AbstractTo determine the clinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura (ITP) in adult Chinese patients, we conducted a retrospective analysis of 220 patients seen at a single center over a 40-year period. The female-to-male ratio was 4:1, with a mean age of 42.1±1.3 years, a mean platelet count of 33.7±2.3×10 9/l, and a mean follow-up of 116±7 months. Initial steroid treatment was required in 142 patients, 67 of whom (47.2%) achieved complete remission (CR). At 470 months, 46% patients remained in CR. Splenectomy was performed in 37 patients: in 23 patients due to primary steroid refractoriness and in 7 patients due to disease relapse following initial CR with steroids. In seven patients, data on response to steroids prior to splenectomy were not available. Splenectomy for steroid nonresponders resulted in an inferior CR rate (13 of 23, 56%) as compared with that for relapses after steroid treatment (7 of 7, 100%) (P<0.05). Compared with patients with negative antinuclear antibody (ANA), those who were ANA positive had similar responses to steroids, but significantly shorter remission after splenectomy (P<0.01). In conclusion, Chinese patients with ITP could maintain long-term remission after steroid therapy and splenectomy. In addition, primary steroid refractoriness and positive ANA were bad prognostic factors of the subsequent response to splenectomy.
Persistent Identifierhttp://hdl.handle.net/10722/77579
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References
Errata

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorChim, CSen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:33:26Z-
dc.date.available2010-09-06T07:33:26Z-
dc.date.issued2001en_HK
dc.identifier.citationAnnals Of Hematology, 2001, v. 80 n. 7, p. 384-386en_HK
dc.identifier.issn0939-5555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77579-
dc.description.abstractTo determine the clinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura (ITP) in adult Chinese patients, we conducted a retrospective analysis of 220 patients seen at a single center over a 40-year period. The female-to-male ratio was 4:1, with a mean age of 42.1±1.3 years, a mean platelet count of 33.7±2.3×10 9/l, and a mean follow-up of 116±7 months. Initial steroid treatment was required in 142 patients, 67 of whom (47.2%) achieved complete remission (CR). At 470 months, 46% patients remained in CR. Splenectomy was performed in 37 patients: in 23 patients due to primary steroid refractoriness and in 7 patients due to disease relapse following initial CR with steroids. In seven patients, data on response to steroids prior to splenectomy were not available. Splenectomy for steroid nonresponders resulted in an inferior CR rate (13 of 23, 56%) as compared with that for relapses after steroid treatment (7 of 7, 100%) (P<0.05). Compared with patients with negative antinuclear antibody (ANA), those who were ANA positive had similar responses to steroids, but significantly shorter remission after splenectomy (P<0.01). In conclusion, Chinese patients with ITP could maintain long-term remission after steroid therapy and splenectomy. In addition, primary steroid refractoriness and positive ANA were bad prognostic factors of the subsequent response to splenectomy.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_HK
dc.relation.ispartofAnnals of Hematologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntibodies, Antinuclear - analysisen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshChinaen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshGlucocorticoids - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrednisolone - therapeutic useen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshPurpura, Thrombocytopenic - ethnology - immunology - physiopathology - therapyen_HK
dc.subject.meshSplenectomyen_HK
dc.titleClinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura in adult Chinese patients: An analysis of 220 casesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0939-5555&volume=80&spage=84&epage=6&date=2001&atitle=Clinicopathologic+and+prognostic+features+of+chronic+idiopathic+thrombocytopenic+purpura+in+adult+Chinese+patients+:+an+analysis+of+220+cases.en_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s002770100306en_HK
dc.identifier.pmid11529462-
dc.identifier.scopuseid_2-s2.0-0034909538en_HK
dc.identifier.hkuros66698en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034909538&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue7en_HK
dc.identifier.spage384en_HK
dc.identifier.epage386en_HK
dc.identifier.isiWOS:000170343400002-
dc.publisher.placeGermanyen_HK
dc.relation.erratumdoi:10.1007/s002770100372-
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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