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Article: Dosage requirement of erythropoietin can be reduced with more frequent administration

TitleDosage requirement of erythropoietin can be reduced with more frequent administration
Authors
KeywordsAnaemia
Erythropoietin
Haemodialysis
Subcutaneous
Issue Date2000
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
Nephrology, 2000, v. 5 n. 1-2, p. 33-38 How to Cite?
AbstractIn short-term studies, once weekly and twice weekly dosing regimens of erythropoietin (EPO) have both been shown to be effective in correcting anaemia in dialysis patients. However, the optimal dosing frequency has yet to be determined. The long-term effects of EPO given by more frequent divided doses in 10 stable haemodialysis patients were studied. The patients achieved a stable haemoglobin level for at least 3 months prior to the study. The frequency of administration was altered from 4000 units once weekly to 2000 units twice weekly in seven patients, from 4000 units once every 10 days to 2000 units twice weekly alternating with 2000 units once weekly in two patients, and from 4000 units fortnightly to 2000 units once weekly in one patient. After the conversion, EPO dosage was adjusted in order to maintain the haemoglobin at the preconversion level. At the end of 28 weeks, the mean haemoglobin level remained unchanged. However, the mean dosage requirement of EPO reduced from 3400 units per week to 2500 units per week (P = 0.019). This represents a significant 26% reduction in dosage and cost. It was concluded that subcutaneous administration of frequent small doses of EPO is a more cost-effective way of correcting anaemia in haemodialysis patients.
Persistent Identifierhttp://hdl.handle.net/10722/77541
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, AYMen_HK
dc.contributor.authorYu, AWYen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLui, SFen_HK
dc.date.accessioned2010-09-06T07:33:01Z-
dc.date.available2010-09-06T07:33:01Z-
dc.date.issued2000en_HK
dc.identifier.citationNephrology, 2000, v. 5 n. 1-2, p. 33-38en_HK
dc.identifier.issn1320-5358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77541-
dc.description.abstractIn short-term studies, once weekly and twice weekly dosing regimens of erythropoietin (EPO) have both been shown to be effective in correcting anaemia in dialysis patients. However, the optimal dosing frequency has yet to be determined. The long-term effects of EPO given by more frequent divided doses in 10 stable haemodialysis patients were studied. The patients achieved a stable haemoglobin level for at least 3 months prior to the study. The frequency of administration was altered from 4000 units once weekly to 2000 units twice weekly in seven patients, from 4000 units once every 10 days to 2000 units twice weekly alternating with 2000 units once weekly in two patients, and from 4000 units fortnightly to 2000 units once weekly in one patient. After the conversion, EPO dosage was adjusted in order to maintain the haemoglobin at the preconversion level. At the end of 28 weeks, the mean haemoglobin level remained unchanged. However, the mean dosage requirement of EPO reduced from 3400 units per week to 2500 units per week (P = 0.019). This represents a significant 26% reduction in dosage and cost. It was concluded that subcutaneous administration of frequent small doses of EPO is a more cost-effective way of correcting anaemia in haemodialysis patients.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEPen_HK
dc.relation.ispartofNephrologyen_HK
dc.subjectAnaemiaen_HK
dc.subjectErythropoietinen_HK
dc.subjectHaemodialysisen_HK
dc.subjectSubcutaneousen_HK
dc.titleDosage requirement of erythropoietin can be reduced with more frequent administrationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1320-5358&volume=5&spage=33&epage=38&date=2000&atitle=Dosage+requirement+of+erythropoietin+can+be+reduced+with+more+frequent+administrationen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1797.2000.00516.xen_HK
dc.identifier.scopuseid_2-s2.0-0034097539en_HK
dc.identifier.hkuros51778en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034097539&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage33en_HK
dc.identifier.epage38en_HK
dc.identifier.isiWOS:000087210500005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWang, AYM=13606226000en_HK
dc.identifier.scopusauthoridYu, AWY=7401478900en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLui, SF=36909925000en_HK

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