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Article: Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model

TitleAdministration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org
Citation
Stroke, 2003, v. 34 n. 3, p. 770-775 How to Cite?
AbstractBackground and Purpose - In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours. The present study was conducted to examine the treatment time window when melatonin was commenced after onset of ischemia. Methods - Adult male Sprague-Dawley rats were anesthetized to undergo right-sided middle cerebral artery occlusion for 3 hours. A single intraperitoneal injection of vehicle or melatonin at 5 mg/kg was given at 0, 1, or 3 hours after onset of ischemia. Other groups received multiple injections of vehicle or melatonin at 5 mg/kg with the first injection given at 1, 2, or 3 hours after onset of ischemia and the second and third injections at 24 and 48 hours, respectively. Multiple injections of melatonin at 15 mg/kg with the first injection given at 3 hours were also made. The infarct volume was determined at 72 hours. Results - A single dose of melatonin at 5 mg/kg given at 0 or 1 but not 3 hours after onset of ischemia reduced the infarct volume. Multiple doses of melatonin at 5 mg/kg also reduced the infarct volume when the first dose was given at 1 or 2 but not 3 hours after onset. Significant hemodynamic effects were not observed. Conclusions - Our results indicate that melatonin at 5 mg/kg given as a single injection or multiple injections protects against focal cerebral ischemia when commenced within 2 hours of onset.
Persistent Identifierhttp://hdl.handle.net/10722/77538
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPei, Zen_HK
dc.contributor.authorPang, SFen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2010-09-06T07:32:59Z-
dc.date.available2010-09-06T07:32:59Z-
dc.date.issued2003en_HK
dc.identifier.citationStroke, 2003, v. 34 n. 3, p. 770-775en_HK
dc.identifier.issn0039-2499en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77538-
dc.description.abstractBackground and Purpose - In both permanent and transient 3-hour middle cerebral artery occlusion rat stroke models, a single intraperitoneal injection of melatonin at 5 or 15 mg/kg given before ischemia was shown to reduce infarct volume at 72 hours. The present study was conducted to examine the treatment time window when melatonin was commenced after onset of ischemia. Methods - Adult male Sprague-Dawley rats were anesthetized to undergo right-sided middle cerebral artery occlusion for 3 hours. A single intraperitoneal injection of vehicle or melatonin at 5 mg/kg was given at 0, 1, or 3 hours after onset of ischemia. Other groups received multiple injections of vehicle or melatonin at 5 mg/kg with the first injection given at 1, 2, or 3 hours after onset of ischemia and the second and third injections at 24 and 48 hours, respectively. Multiple injections of melatonin at 15 mg/kg with the first injection given at 3 hours were also made. The infarct volume was determined at 72 hours. Results - A single dose of melatonin at 5 mg/kg given at 0 or 1 but not 3 hours after onset of ischemia reduced the infarct volume. Multiple doses of melatonin at 5 mg/kg also reduced the infarct volume when the first dose was given at 1 or 2 but not 3 hours after onset. Significant hemodynamic effects were not observed. Conclusions - Our results indicate that melatonin at 5 mg/kg given as a single injection or multiple injections protects against focal cerebral ischemia when commenced within 2 hours of onset.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.orgen_HK
dc.relation.ispartofStrokeen_HK
dc.rightsStroke. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain Edema - pathologyen_HK
dc.subject.meshCerebral Infarction - etiology - pathology - prevention & controlen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshInfarction, Middle Cerebral Artery - complications - drug therapy - pathologyen_HK
dc.subject.meshInjections, Intraperitonealen_HK
dc.subject.meshIschemic Attack, Transient - complications - drug therapy - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMelatonin - pharmacologyen_HK
dc.subject.meshNeuroprotective Agents - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReperfusionen_HK
dc.subject.meshTime Factorsen_HK
dc.titleAdministration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0039-2499&volume=34&spage=770&epage=775&date=2003&atitle=Administration+of+melatonin+after+onset+of+ischemia+reduces+the+volume+of+cerebral+infarction+in+a+rat+middle+cerebral+artery+occlusion+stroke+modelen_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1161/01.STR.0000057460.14810.3Een_HK
dc.identifier.pmid12624306-
dc.identifier.scopuseid_2-s2.0-0037335690en_HK
dc.identifier.hkuros87549en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037335690&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue3en_HK
dc.identifier.spage770en_HK
dc.identifier.epage775en_HK
dc.identifier.isiWOS:000181466700041-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPei, Z=23051646800en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK

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