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Article: 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
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Title15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
 
AuthorsWu, J2 1
Xia, HHX2
Tu, SP2
Fan, DM1
Lin, MCM2
Kung, HF2
Lam, SK2
Wong, BCY2
 
Issue Date2003
 
PublisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
 
CitationCarcinogenesis, 2003, v. 24 n. 2, p. 243-247 [How to Cite?]
DOI: http://dx.doi.org/10.1093/carcin/24.2.243
 
AbstractIt has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer.
 
ISSN0143-3334
2013 Impact Factor: 5.266
 
DOIhttp://dx.doi.org/10.1093/carcin/24.2.243
 
ISI Accession Number IDWOS:000181299600012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWu, J
 
dc.contributor.authorXia, HHX
 
dc.contributor.authorTu, SP
 
dc.contributor.authorFan, DM
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorKung, HF
 
dc.contributor.authorLam, SK
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2010-09-06T07:32:49Z
 
dc.date.available2010-09-06T07:32:49Z
 
dc.date.issued2003
 
dc.description.abstractIt has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationCarcinogenesis, 2003, v. 24 n. 2, p. 243-247 [How to Cite?]
DOI: http://dx.doi.org/10.1093/carcin/24.2.243
 
dc.identifier.doihttp://dx.doi.org/10.1093/carcin/24.2.243
 
dc.identifier.epage247
 
dc.identifier.hkuros79081
 
dc.identifier.isiWOS:000181299600012
 
dc.identifier.issn0143-3334
2013 Impact Factor: 5.266
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid12584173
 
dc.identifier.scopuseid_2-s2.0-0037328659
 
dc.identifier.spage243
 
dc.identifier.urihttp://hdl.handle.net/10722/77523
 
dc.identifier.volume24
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofCarcinogenesis
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCarcinogenesis. Copyright © Oxford University Press.
 
dc.subject.meshApoptosis - drug effects
 
dc.subject.meshArachidonate 15-Lipoxygenase - genetics - metabolism
 
dc.subject.meshBase Sequence
 
dc.subject.meshCaffeic Acids - pharmacology
 
dc.subject.meshCyclooxygenase 2
 
dc.subject.meshCyclooxygenase 2 Inhibitors
 
dc.subject.meshCyclooxygenase Inhibitors - pharmacology
 
dc.subject.meshDNA Primers
 
dc.subject.meshIsoenzymes - drug effects
 
dc.subject.meshLinoleic Acids - pharmacology
 
dc.subject.meshProstaglandin-Endoperoxide Synthases - drug effects
 
dc.subject.meshPyrazoles - pharmacology
 
dc.subject.meshRNA, Messenger - genetics
 
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
 
dc.subject.meshStomach Neoplasms - enzymology - pathology
 
dc.subject.meshSulfonamides - pharmacology
 
dc.subject.meshTumor Cells, Cultured
 
dc.title15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
 
dc.typeArticle
 
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<contributor.author>Lin, MCM</contributor.author>
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Author Affiliations
  1. Xijing Hospital
  2. The University of Hong Kong