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Article: 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer

Title15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
Authors
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
Citation
Carcinogenesis, 2003, v. 24 n. 2, p. 243-247 How to Cite?
Abstract
It has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/77523
ISSN
2013 Impact Factor: 5.266
ISI Accession Number ID
References

 

Author Affiliations
  1. Xijing Hospital
  2. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorWu, Jen_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorTu, SPen_HK
dc.contributor.authorFan, DMen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:32:49Z-
dc.date.available2010-09-06T07:32:49Z-
dc.date.issued2003en_HK
dc.identifier.citationCarcinogenesis, 2003, v. 24 n. 2, p. 243-247en_HK
dc.identifier.issn0143-3334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77523-
dc.description.abstractIt has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/en_HK
dc.relation.ispartofCarcinogenesisen_HK
dc.rightsCarcinogenesis. Copyright © Oxford University Press.en_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshArachidonate 15-Lipoxygenase - genetics - metabolismen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshCaffeic Acids - pharmacologyen_HK
dc.subject.meshCyclooxygenase 2en_HK
dc.subject.meshCyclooxygenase 2 Inhibitorsen_HK
dc.subject.meshCyclooxygenase Inhibitors - pharmacologyen_HK
dc.subject.meshDNA Primersen_HK
dc.subject.meshIsoenzymes - drug effectsen_HK
dc.subject.meshLinoleic Acids - pharmacologyen_HK
dc.subject.meshProstaglandin-Endoperoxide Synthases - drug effectsen_HK
dc.subject.meshPyrazoles - pharmacologyen_HK
dc.subject.meshRNA, Messenger - geneticsen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshStomach Neoplasms - enzymology - pathologyen_HK
dc.subject.meshSulfonamides - pharmacologyen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.title15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-3334&volume=24&issue=2&spage=243&epage=7&date=2003&atitle=15-lipoxygenase-1+mediates+cyclooxygenase-2+inhibitor-induced+apoptosis+in+gastric+canceren_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/carcin/24.2.243en_HK
dc.identifier.pmid12584173en_HK
dc.identifier.scopuseid_2-s2.0-0037328659en_HK
dc.identifier.hkuros79081-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037328659&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue2en_HK
dc.identifier.spage243en_HK
dc.identifier.epage247en_HK
dc.identifier.isiWOS:000181299600012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWu, J=16641439200en_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridTu, SP=7202726555en_HK
dc.identifier.scopusauthoridFan, DM=7202965595en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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