Article: 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer

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Title15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
AuthorsWu, J1 2
Xia, HHX2
Tu, SP2
Fan, DM1
Lin, MCM2
Kung, HF2
Lam, SK2
Wong, BCY2
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
CitationCarcinogenesis, 2003, v. 24 n. 2, p. 243-247 [How to Cite?]
DOI: http://dx.doi.org/10.1093/carcin/24.2.243
AbstractIt has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer.
ISSN0143-3334
2011 Impact Factor: 5.702
2011 SCImago Journal Rankings: 0.692
DOIhttp://dx.doi.org/10.1093/carcin/24.2.243
ISI Accession Number IDWOS:000181299600012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWu, J
dc.contributor.authorXia, HHX
dc.contributor.authorTu, SP
dc.contributor.authorFan, DM
dc.contributor.authorLin, MCM
dc.contributor.authorKung, HF
dc.contributor.authorLam, SK
dc.contributor.authorWong, BCY
dc.date.accessioned2010-09-06T07:32:49Z
dc.date.available2010-09-06T07:32:49Z
dc.date.issued2003
dc.description.abstractIt has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCarcinogenesis, 2003, v. 24 n. 2, p. 243-247 [How to Cite?]
DOI: http://dx.doi.org/10.1093/carcin/24.2.243
dc.identifier.doihttp://dx.doi.org/10.1093/carcin/24.2.243
dc.identifier.epage247
dc.identifier.hkuros79081
dc.identifier.isiWOS:000181299600012
dc.identifier.issn0143-3334
2011 Impact Factor: 5.702
2011 SCImago Journal Rankings: 0.692
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid12584173
dc.identifier.scopuseid_2-s2.0-0037328659
dc.identifier.spage243
dc.identifier.urihttp://hdl.handle.net/10722/77523
dc.identifier.volume24
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofCarcinogenesis
dc.relation.referencesReferences in Scopus
dc.rightsCarcinogenesis. Copyright © Oxford University Press.
dc.subject.meshApoptosis - drug effects
dc.subject.meshArachidonate 15-Lipoxygenase - genetics - metabolism
dc.subject.meshBase Sequence
dc.subject.meshCaffeic Acids - pharmacology
dc.subject.meshCyclooxygenase 2
dc.subject.meshCyclooxygenase 2 Inhibitors
dc.subject.meshCyclooxygenase Inhibitors - pharmacology
dc.subject.meshDNA Primers
dc.subject.meshIsoenzymes - drug effects
dc.subject.meshLinoleic Acids - pharmacology
dc.subject.meshProstaglandin-Endoperoxide Synthases - drug effects
dc.subject.meshPyrazoles - pharmacology
dc.subject.meshRNA, Messenger - genetics
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshStomach Neoplasms - enzymology - pathology
dc.subject.meshSulfonamides - pharmacology
dc.subject.meshTumor Cells, Cultured
dc.title15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
dc.typeArticle
Author Affiliations
  1. Xijing Hospital
  2. The University of Hong Kong