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Article: The expression of hepatocyte growth factor (HGF) and interleukin 6 (IL-6) in damaged human liver and kidney tissues

TitleThe expression of hepatocyte growth factor (HGF) and interleukin 6 (IL-6) in damaged human liver and kidney tissues
Authors
KeywordsGene transcription
Hepatocyte growth factor
Interleukin-6
Kidney
Liver
Tumor
Issue Date1999
PublisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
Citation
Hepato-Gastroenterology, 1999, v. 46 n. 27, p. 1904-1909 How to Cite?
AbstractBACKGROUND/AIMS: Hepatocyte growth factor (HGF) is a multipotent factor involved in tissue regeneration, tumor invasion and a lot of cellular repair processes. Recent studies revealed that interleukin 6 (IL-6) level was elevated in damaged human liver and kidney tissues. Since IL-6 is the major cytokine involved in cellular response to tissue injuries, its relationship with HGF in damaged human liver and kidney is suspected. METHODOLOGY: We examined the RNA transcripts of HGF and IL-6 in 16 hepatic and 5 renal tumor tissues using in situ hybridization techniques. RESULTS: Either HGF or IL-6 RNA transcripts was prominently detected in 86% of the samples (14 liver and 4 kidney). Intense signals were found in malignant cells. In liver tissues, intense signals were detected at the rim of regeneration, while in kidney tissues, signals were found in tubular and glomerular epithelium. Both HGF and IL-6 RNA transcripts were simultaneously detected in 11 hepatic (69%) and 4 renal (80%) samples. CONCLUSIONS: The coexistence of the HGF and IL-6 transcripts suggests a close relationship of two cellular factors possibly with a complex genetic regulation.
Persistent Identifierhttp://hdl.handle.net/10722/77485
ISSN
2015 Impact Factor: 0.792
2015 SCImago Journal Rankings: 0.446
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, RTHen_HK
dc.contributor.authorTsek Liew, Cen_HK
dc.contributor.authorNeng Lai, Ken_HK
dc.date.accessioned2010-09-06T07:32:24Z-
dc.date.available2010-09-06T07:32:24Z-
dc.date.issued1999en_HK
dc.identifier.citationHepato-Gastroenterology, 1999, v. 46 n. 27, p. 1904-1909en_HK
dc.identifier.issn0172-6390en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77485-
dc.description.abstractBACKGROUND/AIMS: Hepatocyte growth factor (HGF) is a multipotent factor involved in tissue regeneration, tumor invasion and a lot of cellular repair processes. Recent studies revealed that interleukin 6 (IL-6) level was elevated in damaged human liver and kidney tissues. Since IL-6 is the major cytokine involved in cellular response to tissue injuries, its relationship with HGF in damaged human liver and kidney is suspected. METHODOLOGY: We examined the RNA transcripts of HGF and IL-6 in 16 hepatic and 5 renal tumor tissues using in situ hybridization techniques. RESULTS: Either HGF or IL-6 RNA transcripts was prominently detected in 86% of the samples (14 liver and 4 kidney). Intense signals were found in malignant cells. In liver tissues, intense signals were detected at the rim of regeneration, while in kidney tissues, signals were found in tubular and glomerular epithelium. Both HGF and IL-6 RNA transcripts were simultaneously detected in 11 hepatic (69%) and 4 renal (80%) samples. CONCLUSIONS: The coexistence of the HGF and IL-6 transcripts suggests a close relationship of two cellular factors possibly with a complex genetic regulation.en_HK
dc.languageengen_HK
dc.publisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.htmlen_HK
dc.relation.ispartofHepato-Gastroenterologyen_HK
dc.subjectGene transcriptionen_HK
dc.subjectHepatocyte growth factoren_HK
dc.subjectInterleukin-6en_HK
dc.subjectKidneyen_HK
dc.subjectLiveren_HK
dc.subjectTumoren_HK
dc.titleThe expression of hepatocyte growth factor (HGF) and interleukin 6 (IL-6) in damaged human liver and kidney tissuesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0172-6390&volume=46&issue=27&spage=1904&epage=1909&date=1999&atitle=The+expression+of+hepatocyte+growth+factor+(HGF)+and+interleukin+6+(IL-6)+in+damaged+human+liver+and+kidney+tissuesen_HK
dc.identifier.emailHo, RTH: tinho@hku.hken_HK
dc.identifier.emailNeng Lai, K: knlai@hku.hken_HK
dc.identifier.authorityHo, RTH=rp00497en_HK
dc.identifier.authorityNeng Lai, K=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10430367-
dc.identifier.scopuseid_2-s2.0-0032810386en_HK
dc.identifier.hkuros50638en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032810386&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue27en_HK
dc.identifier.spage1904en_HK
dc.identifier.epage1909en_HK
dc.identifier.isiWOS:000081398700086-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridHo, RTH=8620896500en_HK
dc.identifier.scopusauthoridTsek Liew, C=6504805955en_HK
dc.identifier.scopusauthoridNeng Lai, K=7402135706en_HK

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