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Article: Candida tropicalis fungaemia in adult patients with haematological malignancies: Clinical features and risk factors

TitleCandida tropicalis fungaemia in adult patients with haematological malignancies: Clinical features and risk factors
Authors
KeywordsCandida tropicalis fungaemia
Haematological malignancies
Issue Date2002
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin
Citation
Journal Of Hospital Infection, 2002, v. 50 n. 4, p. 316-319 How to Cite?
AbstractCandida tropicalis fungaemia is a serious opportunistic infection. Eighteen consecutive patients with C. tropicalis fungaemia diagnosed within a five-year period were studied retrospectively. All patients had haematological malignancies treated by chemotherapy or bone marrow transplantation (BMT). Antifungal prophylaxis included nystatin (20 mg daily) for patients receiving chemotherapy, and fluconazole (200 mg daily) for patients undergoing BMT. Sixteen patients had refractory and advanced haematological malignancies. All patients were neutropenic, had central venous catheters, and were receiving treatment with broad-spectrum antibiotics at the time of fungaemia. Septic shock with skin emboli were the most common presenting features. In seven cases, fungaemia was preceded by a positive culture of C. tropicalis in the urine. Concomitant bacteraemia was found in 11 cases, of which six cases were due to Staphylococcus aureus. The overall mortality rate was 56%. The predominance of chemotherapy-treated patients developing fungaemia in this series might be attributable to the omission of fluconazole prophylaxis. The clinicopathologic features and risk factors identified in this study may help design better treatment strategies for this often-lethal complication. © 2002 The Hospital Infection Society.
Persistent Identifierhttp://hdl.handle.net/10722/77460
ISSN
2015 Impact Factor: 2.655
2015 SCImago Journal Rankings: 1.349
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorChim, CSen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorCheng, CCen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:32:08Z-
dc.date.available2010-09-06T07:32:08Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Hospital Infection, 2002, v. 50 n. 4, p. 316-319en_HK
dc.identifier.issn0195-6701en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77460-
dc.description.abstractCandida tropicalis fungaemia is a serious opportunistic infection. Eighteen consecutive patients with C. tropicalis fungaemia diagnosed within a five-year period were studied retrospectively. All patients had haematological malignancies treated by chemotherapy or bone marrow transplantation (BMT). Antifungal prophylaxis included nystatin (20 mg daily) for patients receiving chemotherapy, and fluconazole (200 mg daily) for patients undergoing BMT. Sixteen patients had refractory and advanced haematological malignancies. All patients were neutropenic, had central venous catheters, and were receiving treatment with broad-spectrum antibiotics at the time of fungaemia. Septic shock with skin emboli were the most common presenting features. In seven cases, fungaemia was preceded by a positive culture of C. tropicalis in the urine. Concomitant bacteraemia was found in 11 cases, of which six cases were due to Staphylococcus aureus. The overall mortality rate was 56%. The predominance of chemotherapy-treated patients developing fungaemia in this series might be attributable to the omission of fluconazole prophylaxis. The clinicopathologic features and risk factors identified in this study may help design better treatment strategies for this often-lethal complication. © 2002 The Hospital Infection Society.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhinen_HK
dc.relation.ispartofJournal of Hospital Infectionen_HK
dc.subjectCandida tropicalis fungaemiaen_HK
dc.subjectHaematological malignanciesen_HK
dc.titleCandida tropicalis fungaemia in adult patients with haematological malignancies: Clinical features and risk factorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0195-6701&volume=50&spage=316&epage=319&date=2002&atitle=Candida+tropicalis+fungaemia+in+adult+patients+with+haematological+malignancies:+clinical+features+and+risk+factors.en_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/jhin.2002.1194en_HK
dc.identifier.scopuseid_2-s2.0-0036550466en_HK
dc.identifier.hkuros66608en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036550466&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue4en_HK
dc.identifier.spage316en_HK
dc.identifier.epage319en_HK
dc.identifier.isiWOS:000175538100013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridCheng, CC=37053202600en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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