Article: Evaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population

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TitleEvaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
AuthorsWong, BCY1
Xia, HHX1
Cheung, HKL1
Ng, FH2
Wong, SY2
Chow, KC2
Lin, SK1
Yin, Y1
Wong, WM1
Yuen, MF1
Lam, SK1
Issue Date2003
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
CitationJournal Of Gastroenterology And Hepatology, 2003, v. 18 n. 1, p. 26-31 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
AbstractBackground and Aim: The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During endoscopy, biopsies were taken for the rapid urease test and histological examination as the gold standard. Stool specimens were collected and used for the HpSA and Apollo tests. Results: Overall, 86 patients (39 males and 47 females, with a mean age of 55.8 years) were recruited. Helicobacter pylori infection was present in 44 (51%) patients as determined by the gold standard. The sensitivity, specificity and accuracy were 86.4, 100, and 93.0%, respectively, for the HpSA, and 90.9, 97.6, and 94.2%, respectively, for the Apollo test when cases with equivocal results were considered as positive. In addition, agreement was achieved in 81 (94.2%) cases between the two tests, with a Kappa value of 0.887. Conclusion: Both the HpSA and Apollo tests achieve acceptable sensitivity and excellent specificity, with accuracies of over 90% for the detection of H. pylori infection in the Chinese population. © 2003 Blackwell Publishing Asia Pty Ltd.
ISSN0815-9319
2011 Impact Factor: 2.865
2011 SCImago Journal Rankings: 0.208
DOIhttp://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
ISI Accession Number IDWOS:000180060100005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWong, BCY
dc.contributor.authorXia, HHX
dc.contributor.authorCheung, HKL
dc.contributor.authorNg, FH
dc.contributor.authorWong, SY
dc.contributor.authorChow, KC
dc.contributor.authorLin, SK
dc.contributor.authorYin, Y
dc.contributor.authorWong, WM
dc.contributor.authorYuen, MF
dc.contributor.authorLam, SK
dc.date.accessioned2010-09-06T07:31:49Z
dc.date.available2010-09-06T07:31:49Z
dc.date.issued2003
dc.description.abstractBackground and Aim: The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During endoscopy, biopsies were taken for the rapid urease test and histological examination as the gold standard. Stool specimens were collected and used for the HpSA and Apollo tests. Results: Overall, 86 patients (39 males and 47 females, with a mean age of 55.8 years) were recruited. Helicobacter pylori infection was present in 44 (51%) patients as determined by the gold standard. The sensitivity, specificity and accuracy were 86.4, 100, and 93.0%, respectively, for the HpSA, and 90.9, 97.6, and 94.2%, respectively, for the Apollo test when cases with equivocal results were considered as positive. In addition, agreement was achieved in 81 (94.2%) cases between the two tests, with a Kappa value of 0.887. Conclusion: Both the HpSA and Apollo tests achieve acceptable sensitivity and excellent specificity, with accuracies of over 90% for the detection of H. pylori infection in the Chinese population. © 2003 Blackwell Publishing Asia Pty Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2003, v. 18 n. 1, p. 26-31 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
dc.identifier.doihttp://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
dc.identifier.epage31
dc.identifier.hkuros82161
dc.identifier.isiWOS:000180060100005
dc.identifier.issn0815-9319
2011 Impact Factor: 2.865
2011 SCImago Journal Rankings: 0.208
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid12519220
dc.identifier.scopuseid_2-s2.0-12244299441
dc.identifier.spage26
dc.identifier.urihttp://hdl.handle.net/10722/77431
dc.identifier.volume18
dc.languageeng
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
dc.publisher.placeAustralia
dc.relation.ispartofJournal of Gastroenterology and Hepatology
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAntigens, Bacterial - isolation & purification
dc.subject.meshAsian Continental Ancestry Group
dc.subject.meshFeces - microbiology
dc.subject.meshFemale
dc.subject.meshHelicobacter Infections - diagnosis - ethnology
dc.subject.meshHelicobacter pylori - immunology
dc.subject.meshHumans
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.titleEvaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Ruttonjee Hospital Hong Kong