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Article: Evaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
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TitleEvaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
 
AuthorsWong, BCY1
Xia, HHX1
Cheung, HKL1
Ng, FH2
Wong, SY2
Chow, KC2
Lin, SK1
Yin, Y1
Wong, WM1
Yuen, MF1
Lam, SK1
 
Issue Date2003
 
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
 
CitationJournal Of Gastroenterology And Hepatology, 2003, v. 18 n. 1, p. 26-31 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
 
AbstractBackground and Aim: The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During endoscopy, biopsies were taken for the rapid urease test and histological examination as the gold standard. Stool specimens were collected and used for the HpSA and Apollo tests. Results: Overall, 86 patients (39 males and 47 females, with a mean age of 55.8 years) were recruited. Helicobacter pylori infection was present in 44 (51%) patients as determined by the gold standard. The sensitivity, specificity and accuracy were 86.4, 100, and 93.0%, respectively, for the HpSA, and 90.9, 97.6, and 94.2%, respectively, for the Apollo test when cases with equivocal results were considered as positive. In addition, agreement was achieved in 81 (94.2%) cases between the two tests, with a Kappa value of 0.887. Conclusion: Both the HpSA and Apollo tests achieve acceptable sensitivity and excellent specificity, with accuracies of over 90% for the detection of H. pylori infection in the Chinese population. © 2003 Blackwell Publishing Asia Pty Ltd.
 
ISSN0815-9319
2013 Impact Factor: 3.627
 
DOIhttp://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
 
ISI Accession Number IDWOS:000180060100005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, BCY
 
dc.contributor.authorXia, HHX
 
dc.contributor.authorCheung, HKL
 
dc.contributor.authorNg, FH
 
dc.contributor.authorWong, SY
 
dc.contributor.authorChow, KC
 
dc.contributor.authorLin, SK
 
dc.contributor.authorYin, Y
 
dc.contributor.authorWong, WM
 
dc.contributor.authorYuen, MF
 
dc.contributor.authorLam, SK
 
dc.date.accessioned2010-09-06T07:31:49Z
 
dc.date.available2010-09-06T07:31:49Z
 
dc.date.issued2003
 
dc.description.abstractBackground and Aim: The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During endoscopy, biopsies were taken for the rapid urease test and histological examination as the gold standard. Stool specimens were collected and used for the HpSA and Apollo tests. Results: Overall, 86 patients (39 males and 47 females, with a mean age of 55.8 years) were recruited. Helicobacter pylori infection was present in 44 (51%) patients as determined by the gold standard. The sensitivity, specificity and accuracy were 86.4, 100, and 93.0%, respectively, for the HpSA, and 90.9, 97.6, and 94.2%, respectively, for the Apollo test when cases with equivocal results were considered as positive. In addition, agreement was achieved in 81 (94.2%) cases between the two tests, with a Kappa value of 0.887. Conclusion: Both the HpSA and Apollo tests achieve acceptable sensitivity and excellent specificity, with accuracies of over 90% for the detection of H. pylori infection in the Chinese population. © 2003 Blackwell Publishing Asia Pty Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2003, v. 18 n. 1, p. 26-31 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1440-1746.2003.02926.x
 
dc.identifier.epage31
 
dc.identifier.hkuros82161
 
dc.identifier.isiWOS:000180060100005
 
dc.identifier.issn0815-9319
2013 Impact Factor: 3.627
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid12519220
 
dc.identifier.scopuseid_2-s2.0-12244299441
 
dc.identifier.spage26
 
dc.identifier.urihttp://hdl.handle.net/10722/77431
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
 
dc.publisher.placeAustralia
 
dc.relation.ispartofJournal of Gastroenterology and Hepatology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAntigens, Bacterial - isolation & purification
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshFeces - microbiology
 
dc.subject.meshFemale
 
dc.subject.meshHelicobacter Infections - diagnosis - ethnology
 
dc.subject.meshHelicobacter pylori - immunology
 
dc.subject.meshHumans
 
dc.subject.meshImmunoenzyme Techniques
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.titleEvaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
 
dc.typeArticle
 
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<contributor.author>Wong, SY</contributor.author>
<contributor.author>Chow, KC</contributor.author>
<contributor.author>Lin, SK</contributor.author>
<contributor.author>Yin, Y</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Ruttonjee Hospital Hong Kong