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Article: Evaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population

TitleEvaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
Authors
Issue Date2003
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2003, v. 18 n. 1, p. 26-31 How to Cite?
AbstractBackground and Aim: The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During endoscopy, biopsies were taken for the rapid urease test and histological examination as the gold standard. Stool specimens were collected and used for the HpSA and Apollo tests. Results: Overall, 86 patients (39 males and 47 females, with a mean age of 55.8 years) were recruited. Helicobacter pylori infection was present in 44 (51%) patients as determined by the gold standard. The sensitivity, specificity and accuracy were 86.4, 100, and 93.0%, respectively, for the HpSA, and 90.9, 97.6, and 94.2%, respectively, for the Apollo test when cases with equivocal results were considered as positive. In addition, agreement was achieved in 81 (94.2%) cases between the two tests, with a Kappa value of 0.887. Conclusion: Both the HpSA and Apollo tests achieve acceptable sensitivity and excellent specificity, with accuracies of over 90% for the detection of H. pylori infection in the Chinese population. © 2003 Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77431
ISSN
2014 Impact Factor: 3.504
2014 SCImago Journal Rankings: 1.128
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorCheung, HKLen_HK
dc.contributor.authorNg, FHen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorChow, KCen_HK
dc.contributor.authorLin, SKen_HK
dc.contributor.authorYin, Yen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:31:49Z-
dc.date.available2010-09-06T07:31:49Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2003, v. 18 n. 1, p. 26-31en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77431-
dc.description.abstractBackground and Aim: The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During endoscopy, biopsies were taken for the rapid urease test and histological examination as the gold standard. Stool specimens were collected and used for the HpSA and Apollo tests. Results: Overall, 86 patients (39 males and 47 females, with a mean age of 55.8 years) were recruited. Helicobacter pylori infection was present in 44 (51%) patients as determined by the gold standard. The sensitivity, specificity and accuracy were 86.4, 100, and 93.0%, respectively, for the HpSA, and 90.9, 97.6, and 94.2%, respectively, for the Apollo test when cases with equivocal results were considered as positive. In addition, agreement was achieved in 81 (94.2%) cases between the two tests, with a Kappa value of 0.887. Conclusion: Both the HpSA and Apollo tests achieve acceptable sensitivity and excellent specificity, with accuracies of over 90% for the detection of H. pylori infection in the Chinese population. © 2003 Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntigens, Bacterial - isolation & purificationen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshFeces - microbiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHelicobacter Infections - diagnosis - ethnologyen_HK
dc.subject.meshHelicobacter pylori - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.titleEvaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=18&spage=26&epage=31&date=2003&atitle=Evaluation+of+Two+Stool+Antigen+Tests+for+the+Detection+of+Helicobacter+pylori+Infection+in+the+Chinese+Populationen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1746.2003.02926.xen_HK
dc.identifier.pmid12519220en_HK
dc.identifier.scopuseid_2-s2.0-12244299441en_HK
dc.identifier.hkuros82161en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12244299441&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue1en_HK
dc.identifier.spage26en_HK
dc.identifier.epage31en_HK
dc.identifier.isiWOS:000180060100005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridCheung, HKL=7201839335en_HK
dc.identifier.scopusauthoridNg, FH=16936078000en_HK
dc.identifier.scopusauthoridWong, SY=7404590845en_HK
dc.identifier.scopusauthoridChow, KC=7202180726en_HK
dc.identifier.scopusauthoridLin, SK=7407154296en_HK
dc.identifier.scopusauthoridYin, Y=36847525300en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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